Overexpression of copper/zinc superoxide dismutase decreases ischemia-like astrocyte injury

Free Radical Biology and Medicine

Volumn 38, Issue 8, 2005, Pages 1112-1118

  Wang, Jian ^a   Ma, Joyce H ^a   Giffard, Rona G ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Astrocytes; Cu Zn superoxide dismutase (SOD1); Free radicals; Glucose deprivation; Glutathione; Ischemia; Oxygen glucose deprivation; Reperfusion

Indexed keywords

CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; GLUCOSE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LACTATE DEHYDROGENASE; OXYGEN; RETROVIRUS VECTOR;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN ISCHEMIA; CELL DEATH; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME RELEASE; GENE OVEREXPRESSION; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL;

EID: 15244351475     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2005.01.010     Document Type: Article

References (30)

1. I. Fridovich Superoxide radical and superoxide dismutases Annu. Rev. Biochem. 64 1995 97 112
2. I. Fridovich Superoxide dismutases. An adaptation to a paramagnetic gas J. Biol. Chem. 264 1989 7761 7764
3. P.H. Chan, M. Kawase, K. Murakami, S.F. Chen, Y. Li, B. Calagui, L. Reola, E. Carlson, and C.J. Epstein Overexpression of SOD1 in transgenic rats protects vulnerable neurons against ischemic damage after global cerebral ischemia and reperfusion J. Neurosci. 18 1998 8292 8299
4. T. Kondo, A.G. Reaume, T.T. Huang, E. Carlson, K. Murakami, S.F. Chen, E.K. Hoffman, R.W. Scott, C.J. Epstein, and P.H. Chan Reduction of CuZn-superoxide dismutase activity exacerbates neuronal cell injury and edema formation after transient focal cerebral ischemia J. Neurosci. 17 1997 4180 4189
5. G. Yang, P.H. Chan, J. Chen, E. Carlson, S.F. Chen, P. Weinstein, C.J. Epstein, and H. Kamii Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia Stroke 25 1994 165 170
6. P.H. Chan, H. Kinouchi, C.J. Epstein, E. Carlson, S.F. Chen, S. Imaizumi, and G.Y. Yang Role of superoxide dismutase in ischemic brain injury: reduction of edema and infarction in transgenic mice following focal cerebral ischemia Prog. Brain Res. 96 1993 97 104
7. J.S. Ditelberg, R.A. Sheldon, C.J. Epstein, and D.M. Ferriero Brain injury after perinatal hypoxia-ischemia is exacerbated in copper/zinc superoxide dismutase transgenic mice Pediatr. Res. 39 1996 204 208
8. W. Ying, C.M. Anderson, Y. Chen, B.A. Stein, C.S. Fahlman, J.C. Copin, P.H. Chan, and R.A. Swanson Differing effects of copper,zinc superoxide dismutase overexpression on neurotoxicity elicited by nitric oxide, reactive oxygen species, and excitotoxins J. Cereb. Blood Flow Metab. 20 2000 359 368
9. S.P. Raps, J.C. Lai, L. Hertz, and A.J. Cooper Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons Brain Res. 493 1989 398 401
10. T.K. Makar, M. Nedergaard, A. Preuss, A.S. Gelbard, A.S. Perumal, and A.J. Cooper Vitamin E, ascorbate, glutathione, glutathione disulfide, and enzymes of glutathione metabolism in cultures of chick astrocytes and neurons: evidence that astrocytes play an important role in antioxidative processes in the brain J. Neurochem. 62 1994 45 53
11. R. Dringen, L. Kussmaul, J.M. Gutterer, J. Hirrlinger, and B. Hamprecht The glutathione system of peroxide detoxification is less efficient in neurons than in astroglial cells J. Neurochem. 72 1999 2523 2530
12. Y. Chen, P.H. Chan, and R.A. Swanson Astrocytes overexpressing Cu,Zn superoxide dismutase have increased resistance to oxidative injury Glia 33 2001 343 347
13. L.L. Dugan, V.M. Bruno, S.M. Amagasu, and R.G. Giffard Glia modulate the response of murine cortical neurons to excitotoxicity: glia exacerbate AMPA neurotoxicity J. Neurosci. 15 1995 4545 4555
14. J.Y. Koh, and D.W. Choi Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay J. Neurosci. Methods 20 1987 83 90
15. M.C. Papadopoulos, I.L. Koumenis, L.L. Dugan, and R.G. Giffard Vulnerability to glucose deprivation injury correlates with glutathione levels in astrocytes Brain Res. 748 1997 151 156
16. M. Barkats, S. Millecamps, P. Abrioux, M.C. Geoffroy, and J. Mallet Overexpression of glutathione peroxidase increases the resistance of neuronal cells to Abeta-mediated neurotoxicity J. Neurochem. 75 2000 1438 1446
17. J. Borg, and J. London Copper/zinc superoxide dismutase overexpression promotes survival of cortical neurons exposed to neurotoxins in vitro J. Neurosci. Res. 70 2002 180 189
18. J.S. Beckman Peroxynitrite versus hydroxyl radical: the role of nitric oxide in superoxide-dependent cerebral injury Ann. N.Y. Acad. Sci. 738 1994 69 75
19. B. Halliwell Reactive oxygen species and the central nervous system J. Neurochem. 59 1992 1609 1623
20. R. Dringen, and B. Hamprecht Involvement of glutathione peroxidase and catalase in the disposal of exogenous hydrogen peroxide by cultured astroglial cells Brain Res. 759 1997 67 75
21. R. Dringen, L. Kussmaul, and B. Hamprecht Detoxification of exogenous hydrogen peroxide and organic hydroperoxides by cultured astroglial cells assessed by microtiter plate assay Brain Res. Brain Res. Protoc. 2 1998 223 228
22. K. Murakami, T. Kondo, C.J. Epstein, and P.H. Chan Overexpression of CuZn-superoxide dismutase reduces hippocampal injury after global ischemia in transgenic mice Stroke 28 1997 1797 1804
23. S. Przedborski, V. Kostic, V. Jackson-Lewis, A.B. Naini, S. Simonetti, S. Fahn, E. Carlson, C.J. Epstein, and J.L. Cadet Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-induced neurotoxicity J. Neurosci. 12 1992 1658 1667
24. S. Raha, and B.H. Robinson Mitochondria, oxygen free radicals, disease and ageing Trends Biochem. Sci. 25 2000 502 508
25. X.Q. Shan, T.Y. Aw, and D.P. Jones Glutathione-dependent protection against oxidative injury Pharmacol. Ther. 47 1990 61 71
26. M.E. Gegg, B. Beltran, S. Salas-Pino, J.P. Bolanos, J.B. Clark, S. Moncada, and S.J. Heales Differential effect of nitric oxide on glutathione metabolism and mitochondrial function in astrocytes and neurones: implications for neuroprotection/neurodegeneration? J. Neurochem. 86 2003 228 237
27. C. Ju, K.N. Yoon, Y.K. Oh, H.C. Kim, C.Y. Shin, J.R. Ryu, K.H. Ko, and W.K. Kim Synergistic depletion of astrocytic glutathione by glucose deprivation and peroxynitrite: correlation with mitochondrial dysfunction and subsequent cell death J. Neurochem. 74 2000 1989 1998
28. K. Nakajima, and K. Suzuki Immunochemical detection of metallothionein in brain Neurochem. Int. 27 1995 73 87
29. M. Sato, and I. Bremner Oxygen free radicals and metallothionein Free Radic. Biol. Med. 14 1993 325 337
30. M. Aschner The functional significance of brain metallothioneins FASEB J. 10 1996 1129 1136