C-type lectin-like receptors in peptide-specific HLA class I-restricted cytotoxic T lymphocytes: Differential expression and modulation of effector functions in clones sharing identical TCR structure and epitope specificity

European Journal of Immunology

Volumn 28, Issue 4, 1998, Pages 1134-1142

  Noppen, Christoph ^a   Schaefer, Christoph ^a   Zajac, Paul ^a   Schütz, Alexander ^a   Kocher, Thomas ^a   Kloth, Judith ^a   Heberer, Michael ^a   Colonna, Marco ^b   De Libero, Gennaro ^c   Spagnoli, Giulio C ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

Author keywords

CD94; Killer cell inhibitory receptor; NKG2 A B; T lymphocyte

Indexed keywords

CALCIUM ION; CD8 ANTIGEN; CD94 ANTIGEN; EPITOPE; HLA ANTIGEN CLASS 1; LECTIN RECEPTOR; T LYMPHOCYTE RECEPTOR;

ARTICLE; CALCIUM TRANSPORT; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; HUMAN; NATURAL KILLER CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMINO ACID SEQUENCE; ANTIGENS, CD; ANTIGENS, CD94; BASE SEQUENCE; CLONE CELLS; EPITOPES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; LECTINS, C-TYPE; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 15144350832     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199804)28:04<1134::AID-IMMU1134>3.0.CO;2-G     Document Type: Article

References (29)

1. Moretta, A., Biassoni, R., Bottino, C., Pende, D., Vitale, M., Mingari, M. C. and Moretta, L., Major histocompatibility complex class I-specific receptors on human natural killer and T lymphocytes. Immunol. Rev. 1997. 155: 105-117.
2. Colonna, M., Specificity and function of immunoglobulin superfamily NK cell inhibitory and stimulatory receptors. Immunol. Rev. 1997. 155: 127-133.
3. D'Andrea, A., Chang, C., Phillips, J. H. and Lanier, L. L., Regulation of T cell lymphokine production by killer cell inhibitory receptor recognition of self HLA class I alleles. J. Exp. Med. 1996. 184: 789-794.
4. Mandelboim, O., Davis, D. M., Reyburn, H. T., Valéz-Goméz, M., Shen, E. G., Pazmany, L. and Strominger, J. L., Enhancement of class II-restricted T cell responses by costimulatory NK receptors for class I MHC proteins. Science 1996. 274: 2097-2100.
5. Ikeda, H., Lethé, B., Lehmann, F., Van Bare, N., Baurain, J. F., De Smet, C., Chambost, H., Vitale, M., Moretta, A. and Boon, T., Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor. Immunity 1997. 6: 199-208.
6. Lazetic, S., Chang, C., Houchins, J. P., Lanier, L. L. and Phillips, J. H., Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits. J. Immunol. 1996. 157: 4741-4745.
7. Brooks, A. G., Posch, P. E., Scorzelli, C. J., Borrego, F. and Coligan, J. E., NKG2A complexed with CD94 defines a novel inhibitory natural killer cell receptor. J. Exp. Med. 1997. 185: 795-800.
8. Mingari, M. C., Vitale, C., Schiavetta, F., Cambiaggi, A., Bertone, S., Zunino, A. and Ponte, M., HLA-class I-specific inhibitory receptors of NK type on a subset of human T cells. Chem. Immunol. 1996. 64: 135-145.
9. Carena, I., Shamshiev, A., Donda, A., Colonna, M. and De Libero, G., Major histocompatibility complex class I molecules modulate activation threshold and early signaling of T cell antigen receptor-γδ stimulated by non-peptidic ligands. J. Exp. Med. 1997. 186: 1769-1774.
10. López-Botet, M., Pérez-Villar, J. J., Carretero, M., Rodriguez, A., Melero, I., Bellon, T., Llano, M. and Navarro, F., Structure and function of the CD94 C-type lectin receptor complex involved in recognition of HLA class I molecules. Immunol. Rev. 1997. 155: 165-174.
11. Mingari, M. C., Vitale, C., Cambiaggi, A., Schiavetti, F., Melioli, G., Ferrini, S. and Poggi, A., Cytolytic T lymphocytes displaying natural killer (NK)-like activity: expression of NK-related functional receptors for HLA class I molecules (p58 and CD94) and inhibitory effect on the TCR-mediated target cell lysis or lymphokine production. Int. Immunol. 1995. 7: 697-703.
12. Bouchard, B., Del Marmol, V., Jackson, I. J., Cherif, D. and Dubertret, L., Molecular characterization of a human tyrosinase-related-protein-2 cDNA. Eur. J. Biochem. 1994. 219: 127-134.
13. Wang, R. F., Appella, E., Kawakami, Y., Kang, X. and Rosenberg, S. A., Identification of TRP-2 as a human tumor antigen recognized by cytotoxic T lymphocytes. J. Exp. Med. 1996. 184: 2207-2216.
14. Rammensee, H.-G., Chemistry of peptides associated with MHC class I and class II molecules. Curr. Opin. Immunol. 1995. 7: 85-96.
15. + T lymphocytes in vitro. Cell. Immunol. 1997. 179: 146-152.
16. Lanier, L. L., Natural killer cells: From no receptors to too many. Immunity 1997. 6: 371-378.
17. Pérez-Villar, J. J., Carretero, M., Navarro, F., Melero, I., Rodriguez, A., Bottino, C., Moretta, A. and López-Botet, M., Biochemical and serological evidence for the existence of functionally distinct forms of the CD94 NK cell receptor. J. Immunol. 1996. 157: 5367-5374.
18. Sivori, S., Vitale, M., Bottino, C., Marcenaro, E., Sanseverino, L., Parolina, S., Moretta, L. and Moretta, A., CD94 functions as a natural killer cell inhibitory receptor for different HLA class I alleles: identification of the inhibitory form of CD94 by the use of novel monoclonal antibodies. Eur. J. Immunol. 1996. 26: 2487-2492.
19. Valitutti, S., Müller, S., Dessing, M. and Lanzavecchia, A., Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy. J. Exp. Med. 1996. 183: 1917-1921.
20. + T lymphocyte subsets that express HLA class I-specific inhibitory receptors represent oligoclonally or monoclonally expanded cell populations. Proc. Natl. Acad. Sci. USA 1996. 83: 12433-12438.
21. Juretic, A., Jürgens-Göbel, J., Schaefer, C., Noppen, C., Willimann, T. E., Kocher, T., Zuber, M., Harder, F., Heberer, M. and Spagnoli, G. C., Cytotoxic T-lymphocyte responses against mutated p21 ras peptides: an analysis of specific T-cell-receptor gene usage. Int. J. Cancer 1996. 68: 471-478.
22. Hara, H., Morita, M., Iwaka, T., Hatae, T., Itoyama, Y., Kitamoto, T., Akizuki, S., Goto, I. and Watanabe, T., Detection of human T lymphotrophic virus type I (HTLV-I) proviral DNA and analysis of T cell receptor Vβ CDR3 sequences in spinal cord lesions of HTLV-I-associated myelopathy/tropical spastic paraparesis. J. Exp. Med. 1994. 180: 831-839.
23. β subfamilies. Eur. J. Immunol. 1991. 21: 935-942.
24. Moretta, A., Molecular mechanisms in cell-mediated cytotoxicities. Cell 1997. 90: 13-18.
25. D'Amaro, J., Houbiers, J. G., Drijfhout, J. W., Brandt, R. M., Schipper, R., Bavinck, J. N., Melief, C. J. and Kast, W. M., A computer program for predicting possible cytotoxic-T-lymphocyte epitopes based on HLA-class-I-peptide-binding motifs. Hum. Immunol. 1995. 43: 13-18.
26. Tsung, K., Yim, J. H., Marti, W. R., Buller, M. L. and Norton, J. Gene expression and cytopathic effects of chemically inactivated vaccinia virus. J. Virol. 1996. 70: 165-171.
27. Spagnoli, G. C., Schaefer, C., Willimann, T. E., Kocher, T., Amoroso, A., Juretic, A., Zuber, M., Lüscher, U., Harder, F. and Heberer, M., Peptide-specific CTL in tumor-infiltrating lymphocytes from metastatic melanomas expressing MART-1/Melan-A, gp100 and Tyrosinase genes: a study in an unselected group of HLA-A2.1-positive patients. Int. J. Cancer 1995. 64: 1-9.
28. Houchins, J. P., Yabe, T., McSherry, C. and Bach, F. H., DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. J. Exp. Med. 1991. 173: 1017-1020.
29. Noppen, C., Spagnoli, G. C. and Schaefer, C., Isolation of multiple mRNAs from a few eukaryotic cells: a fast method to obtain templates for RT-PCR. Biotechniques 1996. 21: 394-396.