Ginseng drugs - Molecular and chemical characteristics and possibility as antidementia drugs

Current Topics in Nutraceutical Research

Volumn 3, Issue 1, 2005, Pages 47-64

  Komatsu, Katsuko ^a   Tohda, Chihiro ^a   Zhu, Shu ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Dementia; Ginseng drugs; Ginsenosides; M1; Neurite extension; Panax; Quality evaluation

Indexed keywords

CHIKUSETSU SAPONIN; GINSENG EXTRACT; GINSENOSIDE RB 1; GINSENOSIDE RC; GINSENOSIDE RD; GINSENOSIDE RE; GINSENOSIDE RG 1; GINSENOSIDE RG 2; NOOTROPIC AGENT; PANAX NOTOGINSENG EXTRACT; PROTOPANAXADIOL; RNA 18S; SAPONIN;

ALZHEIMER DISEASE; CHEMICAL COMPOSITION; DEMENTIA; DISEASE MODEL; DRUG EFFICACY; DRUG STRUCTURE; GENE SEQUENCE; GENETIC ANALYSIS; GINSENG; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTESTINE FLORA; MEMORY DISORDER; MOUSE; NERVE CELL DEGENERATION; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NONHUMAN; PLASTID; QUALITY CONTROL; QUANTITATIVE ANALYSIS; REVIEW; SPECIES DIFFERENCE; SYNAPTIC TRANSMISSION; TAXONOMY; TRADITIONAL MEDICINE; TREATMENT OUTCOME;

PANAX; PANAX GINSENG;

EID: 14944362411     PISSN: 15407535     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (73)

1. Attele, A.S., Wu, J.A. and Yuan, C.S. (1999) Ginseng pharmacology. Biochemical Pharmacology 58, 1685-1693.
2. Casley, C.S., Land, J.M., Sharpe, M.A., Clark, J.B., Duchen, M.R. and Canevari, L. (2002) β-Amyloid fragment 25-35 causes mitochondrial dysfunction in primary cortical neurons. Neurobiology of Disease 10, 258-267.
3. Chan-Palay, V. (1991) Alterations in the locus coeruleus in dementias of Alzheimer's and Parkinson's disease. Progress in Brain Research 88, 625-630.
4. Chuang, W.C., Wu, H.K., Sheu, S.J., Chiou, S.H., Chang, H.C. and Chen, Y.P. (1995) A comparative study on commercial samples of Ginseng radix. Planta Medica 61, 459-465.
5. DeKosky, S.T. and Scheff, S.W. (1990) Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity. Annals of Neurology 27, 457-464.
6. Duc, N.M., Nham, N.T, Kasai, R., Ito, A., Yamasaki, K. and Tanaka, O. (1993) Saponins from Vietnamese Ginseng, Panax vietnamensis Ha et Grushv. collected in central Vietnam. I. Chemical & Pharmaceutical Bulletin 41, 2010-2014.
7. Fortina, P., Dotti, G., Conant, R., Monokian, G., Parrella, T., Hitchcock, W., Rappaport, E., Schwartz, E. and Surrey, S. (1992) Detection of the most common mutations causing betathalassemia in Mediterraneans using a multiplex amplification refractory mutation system (MARMS). PCR Methods and Applications 2, 163-166.
8. Fushimi, H., Komatsu, K., Isobe, M. and Namba, T. (1997) Application of PCR-RFLP and MASA analyses on 18S ribosomal RNA gene sequence for the identification of three Ginseng drugs. Biological & Pharmaceutical Bulletin 20, 765-769.
9. Games, D., Adams, D., Alessandrini, R., Barbour, R., Berthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., Guido, T., Hagopian, S., Johnson-Wood, K., Khan, K., Lee, M., Leibowitz, P., Lieberburg, I., Little, S., Masliah, E., McConlogue, L., Montoya-Zavala, M., Mucke, L., Paganini, L., Penniman, E., Power, M., Schenk, D., Seubert, P., Snyder, B., Soriano, F., Tan, H., Vitale, J., Wadsworth, S., Wolozin, B. and Zhao, J. (1995) Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature 373, 523-527.
10. Grace, E.A., Busciglio, J. (2003) Aberrant activation of focal adhesion proteins mediates fibrillar amyloid β-induced neuronal dystrophy. The Journal of Neuroscience 23, 493-502.
11. Grace, E.A., Rabiner, C.A. and Busciglio, J. (2002) Characterization of neuronal dystrophy induced by fibrillar amyloid beta: implications for Alzheimer's disease. Neuroscience 11, 265-273.
12. Gutell, R.R., Weiser, B., Woese, C.R. and Noller, H.F. (1985) Comparative anatomy of 16-S-like ribosomal RNA. Progress in Nucleic Acid Research and Molecular Biology 32, 155-216.
13. Ha, D.T. and Grushvitzky, I.V. (1985) A new species of the genus Panax (Araliaceae) from Vietnam. Botanicheskii Zhurnal 70 519-522.
14. Hara, H. (1970) On the Asiatic species of the genus Panax. The Journal of Japanese Botany 45, 197-212 (Plates X-XII).
15. Hardy, J., Cowburn, R., Barton, A., Reynolds, G., Dodd, P., Wester, P., O'Carroll, A.M., Lofdahl, E. and Winblad, B. (1987) A disorder of cortical GABAergic innervation in Alzheimer's disease. Neuroscience Letters 73, 192-196.
16. Hasegawa, H., Sung, J.-H. and Benno, Y. (1997) Role of human intestinal Prevotella oris in hydrolyzing Ginseng saponins. Planta Medica 63, 436-440.
17. Heinonen, O., Soininen, H., Sorvari, H., Kosunen, O., Paljarvi, L., Koivisto, E. and Riekkinen, P.J.Sr. (1995) Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomenon in Alzheimer's disease. Neuroscience 64, 375-384.
18. 2, a major saponin component of Vietnamese Ginseng: neuronal mechanisms of action. Methods and Findings in Experimental and Clinical Pharmacology 20, 65-76.
19. Hoo, G. and Tseng, C.J. (1973) On the Chinese species of Panax Linn. Acta Phytotaxanomica Sinica 11: 431-438.
20. Hoo, G. and Tseng, C.J. (1978) The Genus Panax. In: Delectis florae reipublicae popularis sinicae agendae academiae sinicae (Eds) Flora reipublicae popularis sinicae, Tomus 54, (Beijing: Sciences Press), pp. 178-188.
21. Hu, J.M., Lavin, M., Wojciechowski, M.F. and Sanderson, M.J. (2000) Phylogenetic systematics of the tribe Millettieae (Leguminosae) based on chloroplast trnK/matK sequences and ITS implications for evolutionary patterns in Papilionoideae. American Journal of Botany 87, 418-430.
22. Hu, X.Y. (1976) The Genus Panax (Ginseng) in Chinese Medicine. Economic Botany 30, 11-28.
23. 2 in the digestive tract of rats. Chemical & Pharmaceutical Bulletin 39, 2357-2361.
24. Komatsu, K., Zhu, S., Fushimi, H., Qui, T.K., Cai, S.Q., Kadota, S. (2001) Phylogenetic analysis based on 18S rRNA gene and mat gene sequences of Panax vietnamensis and five related species. Planta Medica 67, 461-465.
25. 2 from Vietnamese Ginseng, Panax vietnamensis Ha et Grushv. (1). Biological & Pharmaceutical Bulletin 21, 834-838.
26. Li, Y.M., Xu, M., Lai, M.T., Huang, Q., Castro, J.L., DiMuzio-Mower, J., Harrison, T., Lellis, C., Nadin, A., Neduvelil, J.G., Register, R.B., Sardana, M.K., Shearman, M.S., Smith, A.L., Shi, X.P., Yin, K.C., Shafer, J.A., Gardell, S.J. (2000) Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1. Nature 405, 689-694.
27. Lin, H., Bhatia, R. and Lal, R. ( 2001) Amyloid protein forms ion channels: implications for Alzheimer's disease pathophysiology. FASEB Journal 15, 2433-2444.
28. Lou, Z.C., Guo, X.L. and Feng, Y.X. (1979) Renshen (Ginseng). In: Institute of Materia Medica in Chinese Academy of Medical Sciences (Eds) Zhong Yao Zhi (Vol. 1), (Beijing: People's Medical Publishing House), pp. 1-10.
29. 1 improve spatial learning and increase hippocampal synaptophysin level in mice. Journal of Neurosciences Research 63, 509-515.
30. Morita, T., Kasai, R., Kohda, H., Tanaka, O., Zhou, J. and Yang, T.R. (1983) Chemical and morphological study on Chinese Panax japonicus C. A. Meyer (Zhujie-Shen). Chemical & Pharmaceutical Bulletin 31: 3205-3209.
31. Morita, T., Tanaka, O. and Kohda, H. (1985) Saponin composition of rhizomes of Panax japonicus collected in South Kyushu, Japan and its significance in oriental traditional medicine. Chemical & Pharmaceutical Bulletin 33, 3852-3858.
32. Namba, T., Mikage, M., Cai, S.Q, Lou, Z.C. and Tanaka, O. (1988) Pharmacognostical studies of Ginseng folium (II) commercial samples derived from the varieties of Panax pseudo-ginseng Wall. Shoyakugaku Zasshi 42, 19-27.
33. 1 potetiated nerve growth factor (NGF)-induced neurite outgrowth of cultured chick embryonic dorsal root ganglia. Biological & Pharmaceutical Bulletin 17, 509-513.
34. 1 in the rat. Chemical & Pharmaceutical Bulletin 31, 1059-1066.
35. Ogura, H., Kosasa, T., Kuriya, Y. and Yamanishi, Y. (2000) Donepezil, a centrally acting acetylcholinesterase inhibitor, alleviates learning deficits in hypocholinergic models in rats. Methods and Findings in Experimental and Clinical Pharmacology 22, 89-95.
36. Ohsako, T. and Ohnishi, O. (2000) Intra- and interspecific phylogeny of wild Fagopyrum (Polygonaceae) species based on nucleotide sequences of noncoding regions in chloroplast DNA. American Journal of Botany 87, 573-582.
37. Postuma, R.B.He.W., Nunan, J., Beyreuther, K., Masters, C.L., Barrow, C.J. and Small, D.H. (2000) Substrate-bound beta-amyloid peptides inhibit cell adhesion and neurite outgrowth in primary neuronal cultures. Journal of Neurochemistry 74, 1122-1130.
38. Potter, H. and Dressler, D. (2000) The potential of BACE inhibitors for Alzheimer's therapy. Nature Biotechnology. 18, 125-126.
39. Rathbone, M.P., Middlemiss, P.J., Gysbers, J.W., Andrew, C., Herman, M.A., Reed, J.K., Ciccarelli, R., Di Iorio, P. and Caciagli, F. (1999) Trophic effects of purines in neurons and glial cells. Progress in Neurobiology 59, 663-690.
40. Rogers, S.L., Farlow, M.R, Doody, R.S., Mobs, R. and Friedhoff, L.T. (1998) A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease. Donepezil Study Group. Neurology 50, 136-145.
41. 1 in organ cultures of chicken dorsal root ganglia. Japanese Journal of Pharmacology 27, 445-451.
42. Samukawa, K., Yamashita, H., Matsuda, H. and Kubo, M. (1995) Simultaneous analysis of ginsenosides of various ginseng radix by HPLC. Yakugaku Zasshi 115, 241-249.
43. Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., Kholodenko, D., Lee, M., Liao, Z., Lieberburg, I., Motter, R., Mutter, L., Soriano, F., Shopp, G., Vasquez, N., Vandevert, C., Walker, S., Wogulis, M., Yednock, T., Games, D. and Seubert, P. (1999) Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400, 173-177.
44. Shibata, S. (2001) Chemistry and cancer preventing activities of Ginseng saponins and some related triterpenoid compounds. Journal of Korean Medical Sciences 16 (Suppl), 28-37.
45. Soltis, D.E., Soltis, P.S., Nickrent, D.L., Johnson, L.A., Hahn, W.J., Hoot, S.B., Sweere, J.A., Kuzoff, R.K., Kron, KA., Chase, M.W, Swensen, S.M., Zimmer, E.A., Chaw, S.M., Gillespie, L.J., Kress, W.J. and Sytsma. K.J. (1997) Angiosperm phylogeny inferred from 18S ribosomal DNA sequence. Annals of Missouri Botanical Garden 84 1-49.
46. Lys(UUU) gene contains a 2.5-kilobase-pair intron: an open reading frame and a conserved boundary sequence in the intron. Proceedings of the National Academy of Sciences of the United States of America 82, 3557-61.
47. Tanaka, O. (1990) Recent studies on glycosides from plant drugs of Himalaya and Southwestern China: chemographical correlation of Panax species. Pure and Applied Chemistry 62, 1281-1284.
48. Tanaka, O. and Sakai, R. (1984) Saponins of Ginseng and related plants. In: Herz, W., Grisebach, H., (Eds) Progress in the chemistry of organic natural products, (Vienna: Spring-Verlag) pp. 1-76.
49. Tawab, M.A., Bahr, U., Karas, M., Wurglics, M. and Schubert-Zsilavecz, M. (2003) Degeneration of ginsenosides in humans after oral administration. Drug Metabolism and Disposition 31 1065-1071.
50. Tohda, C., Matsumoto, N., Zou, K., Meselhy, R.M. and Komatsu, K. (2002) Axonal and dendritic extension by protopanaxadiol-type saponins from Ginseng drugs in SK-N-SH cells. Japanese Journal of Pharmacology 90, 254-262.
51. 1, a metabolite of protopanaxadiol-type saponins. Neuropsychopharmacology 29, 860-868.
52. Valouskova, V. and Gschanes, A. (1999) Effects of NGF, b-FGF, and cerebrolysin on water maze performance and on motor activity of rats: short- and long-term study. Neurobiology of Learning and Memory 71, 132-149.
53. Watanabe, T., Kawaguchi, K., Suzuki, H., Yoshikawa, T., Takano, A., Isoda, S., Kohda, H. and malla K.J. (1998) Studies on the medicinal plant resources of Himalayas (3), random amplified polymorphic DNA analysis and saponin contents of Himalayan ginseng (Panax pseudoginseng Wall.). Natural Medicines 52, 426-433.
54. Wei, J.X. and Du, Y.C. (Eds) (1996) Panax notoginseng: Modern scientific investigation and application, (Kunming: Yunnan Science and Technology Press), pp. 426-435.
55. Wen, J. and Nowicke, J.W. (1999) Pollen ultrastructure of Panax (the Ginseng genus, Araliaceae), an eastern Asian and eastern North American disjunct genus. American Journal of Botany 86, 1624-1636,
56. Xie, Z., Wei, M., Morgan, T.E., Fabrizio, P., Han, d., Finch, C.E. and Longo V.D. (2002) Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia. The Journal of Neuroscience 22, 3484-3492.
57. Xu, G.J., Xu, L.S., He, H.X. and Jin, R.L. (Eds) (1996) The Chinese Material Medica (Zhong Guo Yao Cai Xue), (Beijing: Pharmaceutical Science Press), pp. 353-364.
58. Yamaguchi, H., Kasai, R., Matsuura, H., Tanaka, O. and Fuwa, T. (1988) High-performance liquid chromatographic analysis of acidic saponins of Ginseng and related plants. Chemical & Pharmaceutical Bulletin 36, 3468-3473.
59. Yang, C.R., Jiang, Z.D., Zhou, J., Sakai, R. and Tanaka, O. (1985) Two new saponins of oleanolic acid from the underground part of Panax stipuleanus Tsai et Feng. Acta Botanica Yunnanica, 7: 103-108.
60. Yang, C.R., Zhou, J. and Tanaka, O. (1988) Chemotaxonomic studies and the utilization of Panax species. Acta Botanica Yunnanica Supplement I, 47-62.
61. Yang, D.Q. (1981) The cyto-taxonomic studies on some species of Panax L. Acta Phytotaxonomica Sinica 19, 298-303.
62. Zhao, R. and MaDaniel, W.F. (1998) Ginseng improves strategic learning by normal and brain-damaged rats. Neuro Report 9, 1618-1624.
63. Zheng, G..Z. and Yang, C.R. (Eds) (1994) Sanchi (Notoginseng): Biology and its Application, (Beijing: Science Press), pp. 85-131.
64. Zhong, Y.M., Nishijo, H., Uwano, T., Tamura, R., Kawanishi, K. and Ono, T. (2000) Red ginseng ameliorated place navigation deficits in young rats with hippocampal lesions and aged rats. Physiology and Behavior 69, 511-525.
65. Zhou, J., Huang, W.G., Wu, M.Z., Yang, C.R., Feng, G.M. and Wu, Z.Y. (1975) Triterpenoids from Panax L. and their relationship with taxonomy and geographical distribution. Acta Phytotaxonomica Sinica 13: 29-45.
66. Zhu, S., Fushimi, H., Cai, S.Q., Chen, H.B. and Komatsu, K. (2002) A new variety of genus Panax from southern Yunnan, China and its nucleotide sequences of 18S ribosomal RNA gene and matK gene. The Journal of Japanese Botany 77, 86-94.
67. Zhu, S., Fushimi, H., Cai, S.Q and Komatsu, K. (2003) Phylogenetic relationship in the genus Panax: inferred from chloroplast trnK gene and nuclear 18S rRNA gene sequences. Planta Medica 69, 647-653.
68. Zhu, S., Fushimi, H., Cai, S.Q. and Komatsu, K. (2004a) Species identification from Ginseng drugs by Multiple Amplification Refractory Mutation System (MARMS). Planta Medica 70, 189-192.
69. Zhu, S., Zou, K., Cai, S.Q., Meselhy, R.M. and Komatsu, K. (2004b) Simultaneous determination of triterpene saponins in Ginseng drugs by high performance liquid chromatography. Chemical & Pharmaceutical Bulletin, 52, 995-998.
70. Zhu, S., Zou, K., Fushimi, H., Cai, S. Q. and Komatsu, K. (2004c) Comparative study on triterpene saponins of Ginseng drugs. Planta Medica 70, 666-677.
71. Zou, K., Zhu S., Tohda, C., Cai, S.Q and Komatsu, K. (2002a) Dammarane-type triterpene saponins from Panax japonicuz. Journal of Natural Products 65, 346-351.
72. Zou, K., Zhu, S., Meselhy, R.M., Tohda, C., Cai, S.Q and Komatsu, K. (2002b) Dammarane-type saponins from Panax japonicus and their neurite outgrowth activity in SK-N-SH cells. Journal of Natural Products 65, 1288-1292.
73. Zou, K., Zhu, S., Cai, S.Q. and Komatsu, K. (2001) Constituents from the underground part of Panax plants: Ye San Qi and Kou Zi Qi. The 121th Annual Meeting of the Pharmaceutical Society of Japan, pp. 110 (Abstract)