Toxoplasma gondii infection of neurons induces neuronal cytokine and chemokine production, but gamma interferon- and tumor necrosis factor-stimulated neurons fail to inhibit the invasion and growth of T. gondii

Infection and Immunity

Volumn 69, Issue 12, 2001, Pages 7889-7893

  Schluter D ^a   Deckert, M ^a   Hof, H ^a   Frei, K ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ARTICLE; CELL DIVISION; HOST PARASITE INTERACTION; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; SWITZERLAND; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ANIMALS; CELLS, CULTURED; CEREBELLUM; INTERFERON TYPE II; INTERLEUKIN-1; INTERLEUKIN-6; MACROPHAGE INFLAMMATORY PROTEIN-1; MICE; MICE, INBRED BALB C; NEURONS; TOXOPLASMA; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035178144     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.12.7889-7893.2001     Document Type: Article

References (31)

1. Chemokines in the CNS: Plurifunctional mediators in diverse states
2. Infection of murine macrophages with Toxoplasma gondii is associated with release of transforming growth factor beta and downregulation of expression of tumor necrosis factor receptors
3. Activated microglia inhibit multiplication of Toxoplasma gondii via a nitric oxide mechanism
4. Effects of cytokines on multiplication of Toxoplasma gondii in microglial cells
5. Transient production of TGF-beta 2 by postnatal cerebellar neurons and its effect on neuroblast proliferation
6. Differential development of Toxoplasma gondii in neural cells
7. The host-parasite relationship of Toxoplasma gondii in the brains of chronically infected mice
8. Host cells of Toxoplasma gondii encystation in infected primary culture from mouse brain
9. Cytokine responses induced by Toxoplasma gondii in astrocytes and microglial cells
10. Acute cerebral toxoplasmosis is induced by in vivo neutralization of TNF-alpha and correlates with the down-regulated expression of inducible nitric oxide synthase and other markers of macrophage activation
11. Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine
12. Effect of cytokines on growth of Toxoplasma gondii in murine astrocytes
13. The importance of leukotrienes in mast cell-mediated Toxoplasma gondii cytotoxicity
14. A protective role for IL-6 during early infection with Toxoplasma gondii
15. In vitro cultivation of Toxoplasma gondii cysts in astrocytes in the presence of gamma interferon
16. Toxoplasma gondii in primary rat CNS cells: Differential contribution of neurons, astrocytes, and microglial cells for the intracerebral development and stage differentiation
17. Eicosanoids are produced by microglia, not by astrocytes, in rat glial cell cultures
18. Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system: Differential regulation by interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha
19. Macrophage-induced cytotoxicity of N-methyl-D-aspartate receptor positive neurons involves excitatory amino acids rather than reactive oxygen intermediates and cytokines
20. Neurons induced to express major histocompatibility complex class I antigen are killed via the perforin and not the Fas (APO-1/CD95) pathway
21. Interferon-gamma-responsive neuronal sites in the normal rat brain: Receptor protein distribution and cell activation revealed by Fos induction
22. Expression pattern and cellular origin of cytokines in the normal and Toxoplasma gondii-infected murine brain
23. Toxoplasma encephalitis of immunocompetent and nude mice: Immunohistochemical characterisation of Toxoplasma antigen, infiltrates and major histocompatibility complex gene products
24. An endogenous 55 kDa TNF receptor mediates cell death in a neural cell line
25. Nerve growth factor and neuroimmune interactions in inflammatory diseases
26. Functional properties of murine macrophages promoted by nerve growth factor
27. Importance of endogenous IFN-gamma for prevention of toxoplasmic encephalitis in mice
28. Impaired resistance to the development of toxoplasmic encephalitis in interleukin-6-deficient mice
29. The effect of anti-IFN-gamma antibody on the protective effect of Lyt-2+ immune T cells against toxoplasmosis in mice
30. Effector cells of both nonhemopoietic and hemopoietic origin are required for interferon (IFN)-gamma- and tumor necrosis factor (TNF)-alpha-dependent host resistance to the intracellular pathogen, Toxoplasma gondii
31. Toxoplasma gondii alters eicosanoid release by human mononuclear phagocytes: Role of leukotrienes in interferon gamma-induced antitoxoplasma activity