Toxoplasma gondii: Role of the phosphatidylcholine-specific phospholipase C during cell invasion and intracellular development

Experimental Parasitology

Volumn 91, Issue 3, 1999, Pages 231-237

  Ricard, Jérôme ^a   Pelloux, Hervé ^a   Favier, Anne Laure ^a   Gross, Uwe ^b   Brambilla, Elisabeth ^c   Ambroise Thomas, Pierre ^a  

^a UNIV GRENOBLE ALPES   (France)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c HÔPITAL MICHALLON   (France)

Author keywords

Apicomplexa; Bradyzoite stage specific antibody; Cyst development; D609 (tricyclodecan 9 yl xanthate); Hepes (N 2 hydroxyethyl piperazine N' 2 ethanesulfonic acid); MRC5 fibroblasts; Multiplication; Protozoa; Prugniaud strain; RH strain; Toxoplasma gondii; Uracil uptake

Indexed keywords

ANTIGEN; MONOCLONAL ANTIBODY; PHOSPHATIDYLCHOLINE; PHOSPHOLIPASE C; TRICYCLO[4.3.0.1]DECAN 9 YL XANTHOGENATE;

ARTICLE; CELL INVASION; CELL MATURATION; CONTROLLED STUDY; CYST; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; NONHUMAN; PRIORITY JOURNAL; TOXOPLASMA GONDII;

APICOMPLEXA; PROTOZOA; TOXOPLASMA GONDII;

EID: 0032789209     PISSN: 00144894     EISSN: None     Source Type: Journal    
DOI: 10.1006/expr.1998.4353     Document Type: Article

References (28)

1. Amtmann E. The antiviral, antitumoural xanthate D609 is a competitive inhibitor of phosphatidylcholine-specific phospholipase C. Drugs under Experimental and Clinical Research. 22:1996;287-294.
2. Amtmann E., Sauer G. Selective killing of tumor cells by xanthates. Cancer Letters. 35:1987;237-244.
3. Ballou L. R., Laulederkind S. J. F., Rosloniec E. F., Raghow R. Ceramide signalling and the immune response. Biochimica et Biophysica Acta. 1301:1996;273-287.
4. Blewett D. A., Miller J. K., Harding J. Simple technique for the direct isolation of toxoplasma tissue cysts from fetal ovine brain. Veterinary Records. 112:1983;98-100.
5. Bohne W., Heesemann J., Gross U. Reduced replication ofToxoplasma gondii. Infection and Immunity. 62:1994;1761-1767.
6. Cai H., Erhardt P., Szeberenyi J., Diaz-Meco M. T., Johansen T., Moscat J., Cooper G. M. Hydrolysis of phosphatidylcholine is stimulated by Ras proteins during mitogenic signal transduction. Molecular and Cellular Biology. 12:1992;5329-5335.
7. De Carvalho L., Yan C. Y., De Souza W. Effect of various digestive enzymes on the interaction ofToxoplasma gondii. Parasitology Research. 79:1993;114-118.
8. Frenkel J. K., Escajadillo A. Cyst rupture as a pathogenic mechanism of toxoplasmic encephalitis. American Journal of Tropical Medicine and Hygiene. 36:1987;517-522.
9. Gazzinelli R. T., Eltoum I., Wynn T. A., Sher A. Acute cerebral toxoplasmosis is induced by in vivo neutralization of TNF-alpha and correlates with the down-regulated expression of inducible nitric oxide synthase and other markers of macrophage activation. Journal of Immunology. 151:1993;3672-3681.
10. Gross U., Bohne W., Lüder C. G. K., Lugert R., Seeber F., Dittrich C., Pohl F., Ferguson D. J. P. Regulation of developmental differentiation in the protozoan parasiteToxoplasma gondii. Journal of Eukaryotic Microbiology. 43:1996;114S-116S.
11. Gross U., Bormuth H., Gaissmaier C., Dittrich C., Krenn V., Bohne W., Ferguson D. J. P. Monoclonal rat antibodies directed againstToxoplasma gondii. Clinical and Diagnostic Laboratory Immunology. 2:1995;542-548.
12. Harris C., Salgo M. P., Tanowitz H. B., Wittner M. In vitro assessment of antimicrobial agents againstToxoplasma gondii. Journal of Infectious Diseases. 157:1987;14-22.
13. Langermans J. A. M., Van der Hulst M. E. B., Nibbering P. H., Hiemstra L., Fransen P. S., Van Hurth R. IFN-gamma-induced L-arginine-dependent toxoplasmastatic activity in murine peritoneal macrophages is mediated by endogenous tumor necrosis factor. Journal of Immunology. 148:1992;568-574.
14. Müller-Decker K. Interruption of TPA-induced signals by an antiviral and antitumoral xanthate compound: Inhibition of a phospholipase C-type reaction. Biochemical and Biophysical Research Communications. 162:1989;198-205.
15. Pelloux H., Pernod G., Polack B., Coursange E., Ricard J., Verna J. M., Ambroise-Thomas P. Influence of cytokines onToxoplasma gondii. Parasitology Research. 82:1996;598-603.
16. Ricard J., Pelloux H., Pathak S., Pipy B., Ambroise-Thomas P. TNFα enhancesToxoplasma gondii. Cellular Signalling. 8:1996;439-442.
17. Saffer L. D., Schwartzman V. A soluble phospholipase ofToxoplasma gondii. Journal of Protozoology. 38:1991;454-460.
18. Sahm M., Fischer H. G., Gross U., Reiter-Owona I., Seitz V. Cyst formation byToxoplasma gondii in vivo. Parasitology Research. 83:1997;659-665.
19. Sauer G., Amtmann E., Melber K., Knapp A., Müller K., Scherm A. DNA and RNA virus species are inhibited by xanthates, a class of antiviral compounds with unique properties. Proceedings ot the National Academy of Sciences USA. 81:1984;3263-3267.
20. Scharton-Kersten T., Yap G., Magram J., Sher A. Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogenToxoplasma gondii. Journal of Experimental Medicine. 185:1997;1261-1273.
21. Schütze S., Berkovic D., Tomsing O., Unger C., Krönke M. Tumor necrosis factor induces rapid production of 1,2 diacyl-glycerol by a phosphatidylcholine-specific phospholipase C. Journal of Experimental Medicine. 174:1991;975-988.
22. Schütze S., Potthoff K., Machleidt T., Berkovic D., Wiegmann K., Krönke M. TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown. Cell. 71:1992;765-776.
23. Soete M., Camus D., Dubremetz J.-F. Experimental induction of bradyzoite-specific antigen expression and cyst formation by the RH strain ofToxoplasma gondii in vitro. Experimental Parasitology. 78:1994;361-370.
24. Spitsin S. V., Farber J. L., Bertovitch M., Moehren G., Koprowski H., Michaels F. H. Human- and mouse-inducible nitric oxide synthase promoters require activation of phosphatidylcholine-specific phospholipase C and NF-κB. Molecular Medicine. 3:1997;315-326.
25. Tomavo S., Boothroyd J. C. Interconnection between organellar functions, development and drug resistance in the protozoan parasiteToxoplasma gondii. International Journal of Parasitology. 25:1995;1293-1299.
26. Van Dijk M. C. M., Muriana F. J. G., De Widt J., Hilkmann H., Van Blitterswijk W. J. Involvement of phosphatidylcholine-specific phospholipase C in platelet-derived growth factor induced activation of the mitogen-activated protein kinase pathway in rat-1 fibroblasts. Journal of Biological Chemistry. 272:1997;11011-11016.
27. Weiss L. M., Laplace D., Takvorian P. M., Tanowitz H. B., Cali A., wittner M. A cell culture system for study of the development ofToxoplasma gondii. Journal of Eukaryotic Microbiology. 42:1995;150-157.
28. Wiegmann K., Schütze S., Machleidt T., Witte D., Krönke M. Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling. Cell. 78:1994;1005-1015.