New delivery vehicle for RNAi

Drug Discovery Today: TARGETS

Volumn 2, Issue 4, 2003, Pages 130-131

  Foubister, Vida ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

DNA DIRECTED RNA POLYMERASE III; DOUBLE STRANDED RNA; DRUG VEHICLE; HERPESVIRUS VECTOR; LENTIVIRUS VECTOR; RNA POLYMERASE II; SMALL INTERFERING RNA; TRANSCRIPTION COREPRESSOR SKI; UNCLASSIFIED DRUG;

DRUG DELIVERY SYSTEM; DRUG SAFETY; EXPRESSION VECTOR; EYE MALFORMATION; GENE OVEREXPRESSION; HUMAN; KNOCKOUT GENE; NEURAL TUBE DEFECT; NONHUMAN; PROTEIN DEFECT; RNA INTERFERENCE; SHORT SURVEY; TISSUE SPECIFICITY; VIRAL GENE THERAPY;

EID: 14944344039     PISSN: 17418372     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1477-3627(03)02353-5     Document Type: Short Survey

References (7)

1. Rubinson, D.A. et al. (2003) A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat. Genet. 33, 401-406
2. Hemann, M.T. et al. (2003) An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Nat. Genet. 33, 396-400
3. Shinagawa, T. and Ishii, S. (2003) Generation of Ski-knockdown mice by expressing a long double-strand RNA from an RNA polymerase II promoter. Genes Dev. 17, 1340-1345
4. McManus, M.T. and Sharp, P.A. (2002) Gene silencing in mammals by small interfering RNAs. Nat. Rev. Genet. 3, 737-747
5. Napoli, C. et al. (1990) Introduction of a chalcone synthase gene into Petunia results in reversible co-suppression of homologous genes in trans. Plant Cell 2, 279-289
6. Elbashir, S.M. et al. (2001) Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494-498
7. Miller, V.M. et al. (2003) Allele-specific silencing of dominant disease genes. Proc. Natl. Acad. Sci. U. S. A. 100, 7195-7200