Generation of a recombinant apolipoprotein E variant with improved biological functions: Hydrophobic residues (LEU-261, TRP-264, PHE-265, LEU-268, VAL-269) of apoE can account for the apoE-induced hypertriglyceridemia

Journal of Biological Chemistry

Volumn 280, Issue 8, 2005, Pages 6276-6284

  Kypreos, Kyriakos E ^a,b   Van Dijk, Ko W ^b   Havekes, Louis M ^b,c   Zannis, Vassilis I ^a,d  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c TNO   (Netherlands)

^d UNIVERSITY OF CRETE   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; CHOLESTEROL; GENES; MOLECULAR BIOLOGY; MUTAGENESIS;

ALANINES; APOLIPOPROTEIN E (APOE); HIGH DENSITY LIPOPROTEIN (HDL); ULTRACENTRIFUGATION ANALYSIS;

PROTEINS;

ALANINE; AMINO ACID; APOLIPOPROTEIN A1; APOLIPOPROTEIN E; HIGH DENSITY LIPOPROTEIN; LEUCINE; LIPOPROTEIN LIPASE; PHENYLALANINE; RECOMBINANT APOLIPOPROTEIN E; RECOMBINANT PROTEIN; TRIACYLGLYCEROL; TRYPTOPHAN; UNCLASSIFIED DRUG; VALINE; VERY LOW DENSITY LIPOPROTEIN;

ADENOVIRUS; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DENSITY GRADIENT CENTRIFUGATION; ELECTRON MICROSCOPY; FEMALE; GENE TRANSFER; HUMAN; HUMAN CELL; HYDROPHOBICITY; HYPERLIPIDEMIA; HYPERTRIGLYCERIDEMIA; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; APOLIPOPROTEINS E; CHOLESTEROL; FEMALE; HUMANS; HYPERTRIGLYCERIDEMIA; LIPOPROTEINS, HDL; LIPOPROTEINS, VLDL; LIVER; MICE; MICE, KNOCKOUT; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; PEPTIDE FRAGMENTS; RECOMBINANT PROTEINS; TRANSGENES; TRIGLYCERIDES;

EID: 14844327766     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M413458200     Document Type: Article

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