Domains of apolipoprotein E contributing to triglyceride and cholesterol homeostasis in vivo. Carboxyl-terminal region 203-299 promotes hepatic very low density lipoprotein-triglyceride secretion

Journal of Biological Chemistry

Volumn 276, Issue 23, 2001, Pages 19778-19786

  Kypreos, Kyriakos E ^a   Van Dijk, Ko Willems ^a,b   Van Der Zee, Andre ^b   Havekes, Louis M ^c   Zannis, Vassilis I ^a,d  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c TNO   (Netherlands)

^d INSTITUTE OF MOLECULAR BIOLOGY AND BIOTECHNOLOGY   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CHOLESTEROL; PHYSIOLOGY; PLASMAS; PROTEINS; RNA; VIRUSES;

HOMEOSTASIS;

BIOCHEMISTRY;

APOLIPOPROTEIN E; CHOLESTEROL; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN; APOLIPOPROTEIN E4; MESSENGER RNA; PRIMER DNA;

ADENOVIRUS; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FEMALE; GENE TRANSFER; HOMEOSTASIS; HUMAN; HUMAN CELL; HYPERTRIGLYCERIDEMIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; BLOOD; CHEMISTRY; GENETICS; LIQUID CHROMATOGRAPHY; LIVER; METABOLISM; MOUSE MUTANT; NUCLEOTIDE SEQUENCE;

ADENOVIRIDAE; ANIMALIA;

ADENOVIRIDAE; ANIMALS; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; BASE SEQUENCE; CHOLESTEROL; CHROMATOGRAPHY, LIQUID; DNA PRIMERS; FEMALE; HOMEOSTASIS; HUMANS; LIVER; MICE; MICE, KNOCKOUT; RNA, MESSENGER; TRIGLYCERIDES; TUMOR CELLS, CULTURED;

EID: 0035827693     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M100418200     Document Type: Article

References (62)

1. Innerarity, T. L., and Mahley, R. W. (1978) Biochemistry 17, 1440-1447
2. Herz, J., and Willnow, T. E. (1995) Curr. Opin. Lipidol. 6, 97-103
3. Wolf, B. B., Lopes, M. B., VandenBerg, S. R., and Gonias, S. L. (1992) Am. J. Pathol. 141, 37-42
4. Kim, D.-H., Iijima, H., Goto, K., Sakai, J., Ishii, H., Kim, H.-J., Suzuki, H., Kondao, H., Saeki, S., and Yamamoto, T. (1996) J. Biol. Chem. 271, 8373-8380
5. Takahashi, S., Kawarabayasi, Y., Nakai, T., Sakai, J., and Yamamoto, T. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 9252-9256
6. Mahley, R. W., and Huang, Y. (1999) Curr. Opin. Lipidol. 10, 207-217
7. Dong, L.-M., Parkin, S., Trakhanov, S. D., Rupp, B., Simmons, T., Arnold, K. S., Newhouse, Y. M., Innerarity, T. L., and Weisgraber, K. H. (1996) Nat. Struct. Biol. 3, 718-722
8. Wardell, M. R., Brennan, S. O., Janus, E. D., Fraser, R., and Carrell, R. W. (1987) J. Clin. Invest. 80, 483-490
9. Rall, S. C., Jr., Newhouse, Y. M., Clarke, H. R. G., Weisgraber, K. H., McCarthy, B. J., Mahley, R. W., and Bersot, T. P. (1989) J. Clin. Invest. 83, 1095-1101
10. Mann, W. A., Gregg, R. E., Sprecher, D. L., and Brewer, H. B., Jr. (1989) Biochim. Biophys. Acta 1005, 239-244
11. Wardell, M. R., Weisgraber, K. H., Havekes, L. M., and Rall, S. C. Jr. (1989) J. Biol. Chem. 264, 21205-21210
12. van den Maagdenberg, A. M., de Knijff, P., Stalenhoef, A. F., Gevers Leuven, J. A., Havekes, L. M. and Frants, R. R. (1989) Biochem. Biophys. Res. Commun. 165, 851-857
13. Smit, M. P., de Knijff, P., van der Kooij-Meijs, E., Groenendijk, C., van den Maagdenberg, A. M., Gevers Leuven, J. A., Stalenhoef, A. F., Stuyt, P. M., Frants, R. R., and Havekes, L. M. (1990) J. Lipid Res. 31, 45-53
14. Ghiselli, G., Schaefer, E. J., Gascon, P., Brewer, H. B., Jr. (1981) Science 214, 1239-1241
15. Schaefer, E. J., Gregg, R. E., Ghiselli, G., Forte, T. M., Ordovas, J. M., Zech, L. A., and Brewer, H. B. (1986) J. Clin. Invest. 78, 1206-1219
16. Cladaras, C., Hadzopoulou-Cladaras, M., Felber, B. K., Pavlakis, G., and Zannis, V. I. (1987) J. Biol. Chem. 262, 2310-2315
17. Plump, A. S., Smith, J. D., Hayek, T., Aalto-Setala, K., Walsh, A., Verstuyft, J. D., Rubin, E. M., and Breslow, J. L. (1992) Cell 71, 343-353
18. Zhang, S. H., Reddick, R. L., Piedrahita, J. A., and Maeda, N. (1992) Science 258, 468-471
19. Reddick, R. L., Zhang, S. H., and Maeda, N. (1994) Arterioscler. Thromb. Vasc. Biol. 14, 141-147
20. Van den Maagdenberg, A. M. J., Hofker, M. H., Krimpenfort, P. J. A., DeBruijn, I., Van Vlijmen B., van der Boom, H., Havekes, L. M., and Frants, R. R. (1993) J. Biol. Chem. 268, 10540-10545
21. Fazio, S., Lee, Y., Sheng, X., and Rall, S. C. Jr. (1993) J. Clin. Invest. 92, 1497-1503
22. Fazio, S., Horie, Y., Simonet, W. S., Weisgraber, K. H., Taylor, J. M., and Rall, S. C., Jr. (1994) J. Lipid Res. 35, 408-416
23. Fazio, S., Sanan, D. A., Lee, Y.-L., Ji, Z.-S., Mahley, R. W., and Rall, S. C., Jr. (1994) Arterioscler. Thromb. 14, 1873-1879
24. van Vlijmen, B. J., van Dijk, K. W., van't Hof, H. B., van Gorp, P. J., van der Zee, A., van der Boom, H., Breuer, M. L., Hofker, M. H., and Havekes, L. M. (1996) J. Biol. Chem. 271, 30595-30602
25. Cohn, J. S., Tremblay, M., Amiol, M., Bouthillier, D., Roy, M., and Genes, J. Jr. (1996) Arterioseler. Thromb. Vacs. Biol. 16, 149-159
26. Chait, A., Hazzard, W. R., Albers, J. J., Kishwaha, R. P., and Brunzell, J. D. (1978) Metabolism 27, 1055-1066
27. Ehnholm, C., Mahley, R. W., Chappell, D. A., Weisgraber, K. H., Ludwig, E., and Witzlum, J. L. (1984) Proc. Natl. Acad. Sci. U. S. A. 81, 5566-5570
28. Huang, Y., van Eckardstein, A., Wu, S., Maeda, N., and Assmann, G. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 1834-1838
29. Huang, Y., Langer, C., Raabe, M., Wiesenhutter, B., Wu, S., Seedorf, U., Maeda, N., Assmann, G., and von Eckardstein, A. (1997) Arterioscler. Thromb. Vasc. Biol. 17, 2010-2019
30. Zhu, Z., Bellosta, S., Langer, C., Bernini, F., Pitas, R. E., Mahley, R. W., Assmann, G., and von Eckardstein, A. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 7585-7590
31. Cullen, P., Cignarella, A., Brennhausen, B., Mohr, S., Assmann, G., and von Eckardstein, A. (1998) J. Clin. Invest. 101, 1670-1677
32. Linton, M. F., Atkinson, J. B., and Fazio, S. (1995) Science 267, 1034-1037
33. Fazio, S., Babaev, V. R., Murray, A. B., Haty, A. H., Carter, K. J., Gleaves, L. A., Atkinson, J. B., and Linton, M. F. (1997) Proc. Natl. Acad. Sci. U. S. A. 95, 4647-4652
34. Shimano, H., Ohsuga, J., Shimada, M., Namba, Y., Gotoda, T., Harada, K., Katsuki, M., Yazaki, Y., and Yamada, N. (1995) J. Clin. Invest. 95, 469-476
35. Huang, Y., Li, X. O., Rall, S. C., Jr., Taylor, J. M., von Eckardstein, A., and Assmann, G. (1998) J. Biol. Chem. 273, 26388-26393
36. Huang, Y., Liu, X. O., Rall, S. C., Jr., and Mahley, R. W. (1998) J. Biol. Chem. 273, 17483-17490
37. Rensen, P. C. N., and van Berkel, T. J. C. (1998) J. Biol. Chem. 271, 14791-14799
38. Jong, M. C., Dahlmans, V. E. H., Hofker, and M. H., Havekes, L. M. (1997) Biochem. J. 328, 745-750
39. Huang, Y., Ji, Z.-S., Brecht, W. J., Rall, S. C., Jr., Taylor, J. M., and Mahley, R. W. (1999) Arterioscler. Thromb. Vasc. Biol. 19, 2952-2959
40. Kulpers, F., Jong, M. C., Lin, Y., van Eck, M., Havinga, R., and Bloke, V. (1997) J. Clin. Invest. 100, 2915-2922
41. Aleshkov, S. A., Abraham, C. R., and Zannis, V. I. (1998) Biochemistry 36, 10571-10580
42. He, T. C., Zhou, S., da Costa, L. T., Yu, J., Kinzler, K. W., and Vogelstein, B. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 2509-2514
43. Fallaux, F. J., Kranenburg, O., Cramer, S. J., Houweling, A., Van Ormondt, H., Hoeben, R. C., and Van Der Eb, A. J. (1996) Hum. Gene Ther. 7, 215-222
44. van Ree, J. H., van den Broek, W. J., Dahlmans, V. E., Groot, P. H., Vidgeon-Hart, M., Frants, R. R., Wieringa, B., Havekes, L. M., and Hofker, M. H. (1994) Atherosclerosis 111, 25-37
45. van Vlijmen, B. J. M., van den Maagdenberg, A. M. J. M., Gijbels, M. J. J., van der Boom, H., HogenEsch, H., Frants, R. R., Hofker, M. H., and Havekes, L. M. (1994) J. Clin. Invest. 93, 1403-1410
46. Aalto-Setala, K., Fisher E. A., Chen, X., Chajek-Shaul, T., Hayek, T., Zechner, R., Walsh, A., Ramakrishnan, R., Ginsberg, H. N., and Breslow, J. L. (1992) J. Clin. Invest. 90, 1889-1900
47. Lalazar, A., Weisgraber, K. H., Rall, S. C., Jr., Giladi, H., Innerarity, T. L., Levanon, A. Z., Boyles, J. K., Amit, B., Gorecki, M., and Mahley, R. W. (1988) J. Biol. Chem. 263, 3542-3545
48. Weisgraber, K. H., Innerarity, T. L., Harde, K. J., Mahley, R. W., Milne, R. W., Marcel, Y. L., and Sparrow, J. T. (1983) J. Biol. Chem. 258, 12348-12354
49. Innerarity, T. L., Friedlander, E. J., Rail, S. C., Jr., Weisgraber, K. H., and Mahley, R. W. (1983) J. Biol. Chem. 258, 12341-12347
50. Fan, J., Ji, Z.-S., Huang, Y., de Silva, H., Sanan, D., and Mahley, R. W. (1998) J. Clin. Invest. 101, 2151-2164
51. Salah, D., Bohnel, K., Gueguen, R., Siesl, G., and Visvikle, S. (1997) J. Lipid Res. 38, 904-912
52. Ji, Z., Brecht, W. J., Miranda, R. D., Hussain, M. M., Innerarity, T. L., and Mahley, R. W. (1993) J. Biol. Chem. 268, 10180-10187
53. Ji, Z. S., Fazio, S., and Mahley, R. W. (1994) J. Biol. Chem. 269, 13421-13428
54. Ji, S-S., Sanan, D. A., and Mahley, R. W.(1995) J. Lipid Res. 36, 583-592
55. Ji, S.-S., Fazio, S., Lee, Y. L., and Mahley, R. W. (1994) J. Biol. Chem. 289, 2784-2772
56. Rall, S. C., Jr., Weisgraber, K. H., Innerarity, T. L., and Mahley, R. W. (1982) Proe. Natl. Acad. Sci. U. S. A. 79, 4696-4703
57. Weisgraber, K. H., Rall, S. C., Jr., Mahley, R. W., Milne, R. W., Marcel, Y. L. and Sparrow, J. T. (1986) J. Biol. Chem. 281, 2068-2076
58. Cardin A. D., Hirose, N., Blankenship, D. T., Jackson, L. R., and Harmony, J. A. K. (1986) Biochem. Biophys. Res. Commun. 134, 783-789
59. Dong, L. M., Wilson, C., Wardell, M. R., Simmons, T., Mahley, R. W., and Weisgraber, K. H. (1994) J. Biol. Chem. 268, 22358-22365
60. Westerlund J. A., and Weisgraber, K. H. (1994) J. Biol. Chem. 268, 15745-15750
61. Wilson, C., Mau, T., Weisgraber, K. H., Wardell, M. R., Mahley, R. W., and Agard, D. A. (1994) Structure 2, 713-718
62. Wilson, C., Wardell, M. R., Weisgraber, K. H., Mahley, R. W., and Agard, D. A. (1991) Science 282, 1817-1822