The amino-terminal 1-185 domain of apoe promotes the clearance of lipoprotein remnants in vivo. The carboxy-terminal domain is required for induction of hyperlipidemia in normal and apoe-deficient mice

Biochemistry

Volumn 40, Issue 20, 2001, Pages 6027-6035

  Kypreos, Kyriakos E ^a   Morani, Pamela ^a   Van Dijk, Ko Willems ^b   Havekes, Louis M ^c   Zannis, Vassilis I ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c TNO   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; GENE TRANSFER; LIPIDS; PROTEINS; RNA;

LIPOPROTEINS;

BIOCHEMISTRY;

APOLIPOPROTEIN E; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; CHOLESTEROL; RNA; TRIACYLGLYCEROL;

ADENOVIRUS; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CONTROLLED STUDY; FEMALE; GENE TRANSFER; HUMAN; HUMAN CELL; HYPERLIPIDEMIA; MOUSE; NONHUMAN; NORTHERN BLOTTING; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; TRIACYLGLYCEROL BLOOD LEVEL;

ADENOVIRIDAE; ANIMALS; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; BIOLOGICAL TRANSPORT, ACTIVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; GENE DELETION; GENETIC VECTORS; HUMANS; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIAS; HYPERTRIGLYCERIDEMIA; LIPOPROTEINS; LIPOPROTEINS, VLDL; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; RNA, MESSENGER; TRIGLYCERIDES; TUMOR CELLS, CULTURED;

EID: 0035918518     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi002414a     Document Type: Article

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