Interference with MCP-1 gene expression by vector generated triple helix-forming RNA oligonucleotides

Cellular and Molecular Life Sciences

Volumn 62, Issue 3, 2005, Pages 362-376

  Kautz, K ^a   Schwarz, M ^a   Radeke, H H ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Antigene strategy; AP 1; Chemokine; Interferon gamma; Monocyte chemoattractant protein 1 (MCP 1); SP 1; Triple helix forming oligonucleotide (TFO); Triplex; Tumour necrosis factor

Indexed keywords

CHEMOKINE; DOUBLE STRANDED DNA; HYBRID PROTEIN; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; OLIGONUCLEOTIDE; PYRIMIDINE; RNA; TUMOR NECROSIS FACTOR ALPHA; CCL2 PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; GENE EXPRESSION; GENE REPRESSION; GENE SEQUENCE; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; PROTEIN BINDING; PROTEIN SECRETION; TRIPLE HELIX; BIOSYNTHESIS; CELL LINE; CONFORMATION; GENE EXPRESSION REGULATION; GENE VECTOR; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEIC ACID HYBRIDIZATION; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROMOTER REGION; RNA INTERFERENCE;

BASE SEQUENCE; CELL LINE; CHEMOKINE CCL2; GENE EXPRESSION REGULATION; GENETIC VECTORS; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; NUCLEIC ACID HYBRIDIZATION; OLIGONUCLEOTIDES; PROMOTER REGIONS (GENETICS); RNA; RNA INTERFERENCE;

EID: 14844322913     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-004-4443-y     Document Type: Article

References (63)

1. Faria M., Wood C. D., Perrouault L., Nelson J. S., Winter A., White M. R. et al. (2000) Targeted inhibition of transcription elongation in cells mediated by triplex-forming oligonucleotides. Proc. Natl. Acad. Sci. USA 97: 3862-3867
2. Intody Z., Perkins B. D., Wilson J. H. and Wensel T. G. (2000) Blocking transcription of the human rhodopsin gene by triplex-mediated DNA photocrosslinking. Nucleic Acids Res. 28: 4283-4290
3. Giovannangeli C., Diviacco S., Labrousse V., Gryaznov S., Charneau P. and Helene C. (1997) Accessibility of nuclear DNA to triplex-forming oligonucleotides: the integrated HIV-1 provirus as a target. Proc. Natl. Acad. Sci. USA 94: 79-84
4. Carbone G. M., McGuffie E. M., Collier A. and Catapano C. V. (2003) Selective inhibition of transcription of the Ets2 gene in prostate cancer cells by a triplex-forming oligonucleotide. Nucleic Acids Res. 31: 833-843
5. Nagatsugi F., Sasaki S., Miller P. S. and Seidman M. M. (2003) Site-specific mutagenesis by triple helix-forming oligonucleotides containing a reactive nucleoside analog. Nucleic Acids Res. 31: e31
6. Rogers F. A., Vasquez K. M., Egholm M. and Glazer P. M. (2002) Site-directed recombination via bifunctional PNA-DNA conjugates. Proc. Natl. Acad. Sci. USA 99: 16695-16700
7. Vasquez K. M., Dagle J. M., Weeks D. L. and Glazer P. M. (2001) Chromosome targeting at short polypurine sites by cationic triplex-forming oligonucleotides. J. Biol. Chem. 276: 38536-38541
8. Vasquez K. M., Narayanan L. and Glazer P. M. (2000) Specific mutations induced by triplex- forming oligonucleotides in mice. Science 290: 530-533
9. Tu G. C., Cao Q. N. and Israel Y. (1995) Inhibition of gene expression by triple helix formation in hepatoma cells. J. Biol. Chem. 270: 28402-28407
10. Orson F. M., Thomas D. W., McShan W. M., Kessler D. J. and Hogan M. E. (1991) Oligonucleotide inhibition of IL2R alpha mRNA transcription by promoter region collinear triplex formation in lymphocytes. Nucleic Acids Res. 19: 3435-3441
11. Porumb H., Gousset H., Letellier R., Salle V., Briane D., Vassy J. et al. (1996) Temporary ex vivo inhibition of the expression of the human oncogene HER2 (NEU) by a triple helix-forming oligonucleotide. Cancer Res. 56: 515-522
12. Postel E. H., Flint S. J., Kessler D. J. and Hogan M. E. (1991) Evidence that a triplex-forming oligodeoxyribonucleotide binds to the c-myc promoter in HeLa cells, thereby reducing c-myc mRNA levels. Proc. Natl. Acad. Sci. USA 88: 8227-8231
13. Thomas T. J., Faaland C. A., Gallo M. A. and Thomas T. ( 1995) Suppression of c-myc oncogene expression by a polyamine-complexed triplex forming oligonucleotide in MCF-7 breast cancer cells. Nucleic Acids Res. 23: 3594-3599
14. Kochetkova M. and Shannon M. F. (1996) DNA triplex formation selectively inhibits granulocyte-macrophage colony-stimulating factor gene expression in human T cells. J. Biol. Chem. 271: 14438-14444
15. Cheng A. J. and Van Dyke M. W. (1994) Oligodeoxyribonucleotide length and sequence effects on intermolecular purine-purine-pyrimidine triple-helix formation. Nucleic Acids Res. 22: 4742-4747
16. Uguccioni M., D'Apuzzo M., Loetscher M., Dewald B. and Baggiolini M. (1995) Actions of the chemotactic cytokines MCP-1, MCP-2, MCP-3, RANTES, MIP-1 alpha and MIP-1 beta on human monocytes. Eur. J. Immunol. 25: 64-68
17. Carr M. W., Roth S. J., Luther E., Rose S. S. and Springer T. A. (1994) Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. Proc. Natl. Acad. Sci. USA 91: 3652-3656
18. Loetscher P., Seitz M., Clark-Lewis I., Baggiolini M. and Moser B. (1994) Monocyte chemotactic proteins MCP-1, MCP-2, and MCP-3 are major attractants for human CD4+ and CD8+T lymphocytes. FASEB J. 8: 1055-1060
19. Roth S. J., Carr M. W. and Springer T. A. (1995) C-C chemokines, but not the C-X-C chemokines interleukin-8 and interferon-gamma inducible protein-10, stimulate transendothelial chemotaxis of T lymphocytes. Eur. J. Immunol. 25: 3482-3488
20. Weber M., Uguccioni M., Ochensberger B., Baggiolini M., Clark-Lewis I. and Dahinden C. A. (1995) Monocyte chemotactic protein MCP-2 activates human basophil and eosinophil leukocytes similar to MCP-3. J. Immunol. 154: 4166-4172
21. Frade J. M., Mellado M., Real G. del, Gutierrez-Ramos J. C., Lind P. and Martinez A. (1997) Characterization of the CCR2 chemokine receptor: functional CCR2 receptor expression in B cells. J. Immunol. 159: 5576-5584
22. Rollins B. J., Yoshimura T., Leonard E. J. and Pober J. S. (1990) Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE. Am. J. Pathol. 136: 1229-1233
23. Rovin B. H., Yoshiumura T. and Tan L. (1992) Cytokine-induced production of monocyte chemoattractant protein-1 by cultured human mesangial cells. J. Immunol. 148: 2148-2153
24. Schwarz M., Radeke H. H., Resell K. and Uciechowski P. (1997) Lymphocyte-derived cytokines induce sequential expression of monocyte- and T cell-specific chemokines in human mesangial cells. Kidney Int. 52: 1521-1531
25. Anders H. J., Vielhauer V., Kretzler M., Cohen C. D., Segerer S., Luckow B. et al. (2001) Chemokine and chemokine receptor expression during initiation and resolution of immune complex glomerulonephritis. J. Am. Soc. Nephrol. 12: 919-931
26. Brown Z., Robson R. L. and Westwick J. (1996) Regulation and expression of chemokines: potential role in glomerulonephritis. J. Leukoc. Biol. 59: 75-80
27. Hora K., Satriano J. A., Santiago A., Mori T., Stanley E. R., Shan Z. et al. (1992) Receptors for IgG complexes activate synthesis of monocyte chemoattractant peptide 1 and colony-stimulating factor 1. Proc. Natl. Acad. Sci. USA 89: 1745-1749
28. Panzer U., Thaiss F., Zahner G., Barth P., Reszka M., Reinking R. R. et al. (2001) Monocyte chemoattractant protein-1 and osteopontin differentially regulate monocytes recruitment in experimental glomerulonephritis. Kidney Int. 59: 1762-1769
29. Radeke H. H., Janssen-Graalfs I., Sowa E. N., Chouchakova N., Skokowa J., Loscher F. et al. (2002) Opposite regulation of type II and III receptors for immunoglobulin G in mouse glomerular mesangial cells and in the induction of anti-glomerular basement membrane (GBM) nephritis. J. Biol. Chem. 277: 27535-27544
30. Stahl R. A., Thaiss F., Disser M., Helmchen U., Hora K. and Schlondorff D. (1993) Increased expression of monocyte chemoattractant protein-1 in anti- thymocyte antibody-induced glomerulonephritis. Kidney Int. 44: 1036-1047
31. Tesch G. H., Schwarting, A., Kinoshita K., Lan H. Y., Rollins B. J. and Kelley V. R. (1999) Monocyte chemoattractant protein-1 promotes macrophage-mediated tubular injury, but not glomerular injury, in nephrotoxic serum nephritis. J. Clin. Invest 103: 73-80
32. Boring L., Gosling J., Cleary M. and Charo I. F. (1998) Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature 394: 894-897
33. Mahad D. J. and Ransohoff R. M. (2003) The role of MCP-1 (CCL2) and CCR2 in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). Semin. Immunol. 15: 23-32
34. Ping D., Jones P. L. and Boss J. M. (1996) TNF regulates the in vivo occupancy of both distal and proximal regulatory regions of the MCP-1/JE gene. Immunity 4: 455-469
35. Cochran B. H., Reffel A. C. and Stiles C. D. (1983) Molecular cloning of gene sequences regulated by platelet-derived growth factor. Cell 33: 939-947
36. Zhou Z. H., Chaturvedi P., Han Y. L., Aras S., Li Y. S., Kolattukudy P. E. et al. (1998) IFN-gamma induction of the human monocyte chemoattractant protein (hMCP)-1 gene in astrocytoma cells: functional interaction between an IFN-gamma-activated site and a GC-rich element. J. Immunol. 160: 3908-3910
37. Zoja C., Wang J. M., Bettoni S., Sironi M., Renzi D., Chiaffarino F. et al. (1991) Interleukin-1 beta and tumour necrosis factor-alpha induce gene expression and production of leukocyte chemotactic factors, colony-stimulating factors, and interleukin-6 in human mesangial cells. Am. J. Pathol. 138: 991-1003
38. Faller D. V., Weng H., Graves D. T. and Choi S. Y. (1997) Moloney murine leukemia virus long terminal repeat activates monocyte chemotactic protein-1 protein expression and chemotactic activity. J. Cell Physiol 172: 240-252
39. Glabinski A. R., Balasingam V., Tani M., Kunkel S. L., Strieter R. M., Yong V. W. et al. (1996) Chemokine monocyte chemoattractant protein-1 is expressed by astrocytes after mechanical injury to the brain. J. Immunol. 156: 4363-4368
40. Ping D., Boekhoudt G. H., Rogers E. M. and Boss J. M. (1999) Nuclear factor-kappa B p65 mediates the assembly and activation of the TNF-responsive element of the murine monocyte chemoattractant-1 gene. J. Immunol. 162: 727-734
41. Ueda A., Okuda K., Ohno S., Shirai A., Igarashi T., Matsunaga K. et al. (1994) NF-kappa B and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene. J. Immunol. 153: 2052-2063
42. Ping D., Boekhoudt G. and Boss J. M. (1999) Trans-retinoic acid blocks platelet-derived growth factor-BB-induced expression of the murine monocyte chemoattractant-1 gene by blocking the assembly of a promoter proximal Sp1 binding site. J. Biol. Chem. 274: 31909-31916
43. Wenzel U., Schneider A., Valente A. J., Abboud H. E., Thaiss F., Helmchen U. M. et al. (1997) Monocyte chemoattractant protein-1 mediates monocyte/macrophage influx in anti-thymocyte antibody-induced glomerulonephritis. Kidney Int. 51: 770-776
44. Marchand P., Resch K. and Radeke H. H. (2000) Selective inhibition of monocyte chemoattractant protein-1 gene expression in human embryonal kidney cells by specific triple helix-forming oligonucleotides. J. Immunol. 164: 2070-2076
45. Noonberg S. B., Scott G. K., Hunt C. A. and Benz C. C. (1994) Detection of triplex-forming RNA oligonucleotides by triplex blotting. Biotechniques 16: 1070-1072, 1074
46. Escude C., Francois J. C., Sun J. S., Ott G., Sprinzl M., Garestier T. et al. (1993) Stability of triple helices containing RNA and DNA strands: experimental and molecular modeling studies. Nucleic Acids Res. 21: 5547-5553
47. Semerad C. L. and Maher L. J. III (1994) Exclusion of RNA strands from a purine motif triple helix. Nucleic Acids Res. 22: 5321-5325
48. Lacroix L., Mergny J. L., Leroy J. L. and Helene C. (1996) Inability of RNA to form the i-motif: implications for triplex formation. Biochemistry 35: 8715-8722
49. Han H. and Dervan P.B. (1993) Sequence-specific recognition of double helical RNA and RNA.DNA by triple helix formation. Proc. Natl. Acad. Sci. USA 90: 3806-3810
50. Roberts R. W. and Crothers D. M. (1992) Stability and properties of double and triple helices: dramatic effects of RNA or DNA backbone composition. Science 258: 1463-1466
51. Cogoi S., Suraci C., Del Terra E., Diviacco S., Marel G. van der, Boom J. van et al. (2000) Downregulation of c-Ki-ras promoter activity by triplex-forming oligonucleotides endogenously generated in human 293 cells. Antisense Nucleic Acids Drug Dev. 10: 283-295
52. Noonberg S. B., Scott G. K., Garovoy M. R., Benz C. C. and Hunt C. A. (1994) In vivo generation of highly abundant sequence-specific oligonucleotides for antisense and triplex gene regulation. Nucleic Acids Res. 22: 2830-2836
53. Datta H. J. and Glazer P. M. (2001) Intracellular generation of single-stranded DNA for chromosomal triplex formation and induced recombination. Nucleic Acids Res. 29: 5140-5147
54. Rininsland F., Johnson T. R., Chernicky C. L., Schulze E., Burfeind P. and Ilan J. (1997) Suppression of insulin-like growth factor type I receptor by a triple-helix strategy inhibits IGF-I transcription and tumourigenic potential of rat C6 glioblastoma cells. Proc. Natl. Acad. Sci. USA 94: 5854-5859
55. Shevelev A., Burfeind P., Schulze E., Rininsland F., Johnson T. R., Trojan J. et al. (1997) Potential triple helix-mediated inhibition of IGF-I gene expression significantly reduces tumouri-genicity of glioblastoma in an animal model. Cancer Gene Ther. 4: 105-112
56. Ririe S. S. and Guntaka R. V. (1998) An RNA oligonucleotide corresponding to the polypyrimidine region of the rat alpha 1(1) procollagen promoter forms a stable triplex and inhibits transcription. Biochem. Biophys. Res. Commun. 249: 218-221
57. Chan P. P. and Glazer P. M. (1997) Triplex DNA: fundamentals, advances, and potential applications for gene therapy. J. Mol. Med. 75: 207-282
58. Miller P. S., Bhan P., Cushman C. D. and Trapane T. L. (1992) Recognition of a guanine-cytosine base pair by 8-oxoadenine. Biochemistry 31: 6788-6793
59. Soukup G. A., Ellington A. D. and Maher L. J. III (1996) Selection of RNAs that bind to duplex DNA at neutral pH. J. Mol. Biol. 259: 216-228
60. Weisz O. A. (2003) Organelle acidification and disease. Traffic. 4: 57-64
61. Llopis J., McCaffery J. M., Miyawaki A., Farquhar M. G. and Tsien R. Y. (1998) Measurement of cytosolic, mitochondrial, and Golgi pH in single living cells with green fluorescent proteins. Proc. Natl. Acad. Sci. USA 95: 6803-6808
62. Zhou R., Geiger R. C. and Dean D. A. (2004) Intracellular trafficking of nucleic acids. Expert Opin. Drug Deliv. 1: 127-140
63. Macris M. A. and Glazer P. M. (2003) Transcription dependence of chromosomal gene targeting by triplex-forming oligonucleotides. J. Biol. Chem. 278: 3357-3362