Moloney murine leukemia virus long terminal repeat activates monocyte chemotactic protein-1 protein expression and chemotactic activity

Journal of Cellular Physiology

Volumn 172, Issue 2, 1997, Pages 240-252

  Faller, Douglas V ^a,c   Weng, Haiqin ^a   Graves, Dana T ^b   Choi, Sang Yun ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Harvard Scool of Dental Medicine   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

MONOCYTE CHEMOTACTIC PROTEIN 1;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CHEMOTAXIS; GENE EXPRESSION; GENETIC TRANSCRIPTION; LONG TERMINAL REPEAT; MOLONEY LEUKEMIA ONCOVIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CHEMOKINE CCL2; CHEMOTAXIS, LEUKOCYTE; HELA CELLS; HUMANS; MICE; MICE, INBRED BALB C; MOLONEY MURINE LEUKEMIA VIRUS; REPETITIVE SEQUENCES, NUCLEIC ACID; RNA, MESSENGER; TRANS-ACTIVATION (GENETICS); TUMOR CELLS, CULTURED;

ANIMALIA; MOLONEY MURINE LEUKEMIA VIRUS; MURINAE; ONCOVIRINAE; UNIDENTIFIED RETROVIRUS;

EID: 0030739807     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(199708)172:2<240::AID-JCP11>3.0.CO;2-D     Document Type: Article

References (94)

1. Allavena, P., Blanchi, G., Zhou, D., Vandamme, J., Jilek, P., Sozzani, S., and Mantovani, A. (1994) Induction of natural killer cell migration by monocyte chemotactic protein-1, -2 and -3. Eur. J. Immunol., 24:3233-3236.
2. Andrews, N.C., and Faller, D.V. (1991) A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res., 19:2499.
3. Baggiolini, M., Dewald, B., and Moser, B. (1994) Interleukin-8 and related chemotactic cytokines: CXC and CC chemokines. Adv. Immunol., 55:97-179.
4. Barna, B.P., Pettay, J., Barnett, G.H., Zhou, P., Iwasaki, K., and Estes, M.L. (1994) Regulation of monocyte chemoattractant protein-1 expression in adult human non-neoplastic astrocytes is sensitive to tumor necrosis factor (TNF) or antibody to the 55-kDa TNF receptor. J. Neuroimmunol., 50:101-107.
5. Bedard, P.A., and Golds, E.E. (1993) Cytokine-induced expression of mRNAs for chemotactic factors in human synovial cells and fibreblasts. J. Cell Physiol., 154:433-440.
6. Brightman, B.K., Davis, B.R., and Fan, H. (1990) Preleukemic hematopoietic hyperplasia induced by Moloney murine leukemia virus is an indirect consequence of viral infection. J. Virol., 64:4582-4584.
7. Brightman, B.K., Rein, A., Trepp, D.J., and Fan, H. (1991) An enhancer variant of Moloney murine leukemia virus defective in leukemogenesis does not generate detectable mink cell focus-inducing virus in vivo. Proc. Natl. Acad. Sci. USA, 88:2264-2268.
8. Carr, M.W., Roth, S.J., Luther, E., Rose, S.S., and Springer, T.A. (1994) Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. Proc. Natl. Acad. Sci. USA, 91:3652-3656.
9. Carr, M.W., Alon, R., and Springer, T.A. (1996) The C-C chemokine MCP-1 differentially modulates the avidity of beta 1 and beta 2 integrins on T lymphocytes. Immunity, 4:179-187.
10. Celander, D. and Haseltine, W.A. (1984) Tissue-specific transcription preference as a determinant of cell tropism and leukaemogenic potential of murine retroviruses. Nature, 312:159-162.
11. Cepko, C.L., Roberts, B.E., and Mulligan, R.C. (1984) Construction and applications of a highly transmissible murine retrovirus shuttle vector. Cell, 37:1053-1062.
12. Chazon, R., and Naron-Chera, N. (1976) The role of thymus subpopulations in "T" leukemia development. Cell Immunol., 23:356-375.
13. Chirgwin, J.M., Przybyla, A.E., MacDonald, R.J., and Rutter, W.J. (1979) Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry, 18:5294-5299.
14. Choi, S.Y., and Faller, D.V. (1994) The long terminal repeats of a murine retrovirus encode a trans-activator for cellular genes. J. Biol. Chem., 269:19691-19694.
15. Choi, S.Y., and Faller, D.V. (1995) A transcript from the long terminal repeats of a murine retrovirus associated with trans-activation of cellular genes. J. Virol., 69:7054-7060.
16. Choi, S.Y., VanDeMark, K., and Faller, D.V. (1997) Identification of a cis-acting element in the class I major histocompatibility complex gene promoter responsive to activation by retroviral sequences. J. Virol., 71:965-970.
17. Cuypers, H.T., Selten, G., Quint, W., Zijlstra, M., Maandag, E.R., Boelens, W., van Wezenbeek, P., Melief, C., and Berns, A. (1994) Murine leukemia virus-induced T-cell lymphomagenesis: Integration of provirus in a distinct chromosomal region. Cell, 37:141-150.
18. Davis, B., Linney, E., and Fan, H. (1985) Suppression of leukaemia virus pathogenicity by polyoma virus enhancers. Nature, 314:550-553.
19. Davis, B.R., Brightman, B.K., Chandy, K.G., and Fan, H. (1987) Characterization of a preleukemic state induced by Moloney murine leukemia virus: Evidence for two infection events during leukemogenesis. Proc. Natl. Acad. Sci. USA, 84:4875-4879.
20. Falk, W., Goodwin, R.H., and Leonard, E.J. (1980) A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration. J. Immunol. Meth., 33:239-247.
21. Faller, D.V. (1995) Modulation of MHC antigen expression by retroviruses. In: MHC Antigen Expression and Disease. G.E. Blair, D.J. Maudsley, and C.R. Pringle, eds., Cambridge University Press, Cambridge, Vol. 1, pp. 150-191.
22. Faller, D.V., Wilson, L.D., and Flyer, D.C. (1988) Mechanism of induction of class I major histocompatibility antigen expression by murine leukemia virus. J. Cell Biochem., 36:297-309.
23. Faller, D.V., Weng, H.Q., and Choi, S.Y. (1997) Activation of collagenase IV gene expression and enzymatic activity by the Moloney leukemia virus Long Terminal Repeat. Virology, 227:331-342.
24. Fan, H. (1990) Influences of the long terminal repeats on retroviral pathogenicity. Semin. Virol., 1:164-174.
25. Feinberg, A.P., and Vogelstein, B. (1983) A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem., 132:6-13.
26. Flyer, D.C., Burakoff, S.J., and Faller, D.V. (1983) Expression of transfected viral glycoprotein genes on the cell surface; recognition and killing by virus-specific cytotoxic T-lymphocytes. Nature, 305:315-318.
27. Flyer, D.C., Burakoff, S.J., and Faller, D.V. (1985a) Expression and CTL recognition of cloned subgenomic fragments of Moloney murine leukemia virus in murine cells. Survey of Immunological Research, 4:168-172.
28. Flyer, D.C., Burakoff, S.J., and Faller, D.V. (1985b) Retrovirus-induced changes in major histocompatibility complex antigen expression influence susceptibility to lysis by cytotoxic T lymphocytes. J. Immunol., 135:2287-2292.
29. Freter, R.R., Alberta, J.A., Lam, K.K., and Stiles, C.D. (1995) A new platelet-derived growth factor-regulated genomic element which binds a serine threonine phosphoprotein mediates induction of the slow immediate-early gene MCP-1. Mol. Cell Biol., 15:315-325.
30. Freter, R.R., Alberta, J.A., Hwang, G.Y., Wrentmore, A.L., and Stiles, C.D. (1996) Platelet-derived growth factor induction of the immediate-early gene MCP-1 is mediated by NF-kappa B and a 90-kDa phosphoprotein coactivator. J. Biol. Chem., 271:17417-17424.
31. Ghosh, D. (1990) A relational database of transcription factors. Nucleic Acids Res., 18:1749-1756.
32. Ghosh, D. (1992) TFD: The transcription factors data base. Nucleic Acids Res., 20:2091-2093.
33. Ginis, I., Mentzer, S.J., Li, X.P., and Faller, D.V. (1995) Characterization of a hypoxia-responsive adhesion molecule for leukocytes on human endothelial cells. J. Immunol., 155:802-810.
34. Gorman, C.M., Moffat, L.F., and Howard, B.H. (1982) Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell Biol., 2:1044-1051.
35. Graves, D.T., and Jiang, Y. (1995) Chemokines, a family of chemotactic cytokines. Crit. Rev. Oral Biol. Med., 6:109-118.
36. Graves, D.T., Jiang, Y.L., Williamson, M.J., and Valente, A.J. (1989) Identification of monocyte chemotactic activity produced by malignant cells. Science, 245:1490-1493.
37. Graves, D.T., Barnhill, R., Galanopoulos, T., and Antoniades, H.N. (1992) Expression of monocyte chemotactic protein-1 in human melanoma in vivo. Am. J. Pathol., 140:9-14.
38. Gruss, H.J., Brach, M.A., Drexler, H.G., Bonifer, R., Mertelsmann, R.H., and Herrmann, F. (1992) Expression of cytokine genes, cytokine receptor genes, and transcription factors in cultured Hodgkin and Reed-Sternberg cells. Cancer Res., 52:3353-3360.
39. Hanazawa, S., Takeshita, A., Amano, S., Semba, T., Nirazuka, T., Katoh, H., and Kitano, S. (1993) Tumor necrosis factor-alpha induces expression of monocyte chemoattractant JE via fos and jun genes in clonal osteoblastic MC3T3-E1 Cells. J. Biol. Chem., 268:9526-9532.
40. Hayward, W.S., Neel, B.G., and Astrin, S.M. (1981) Activation of a cellular one gene by promoter insertion in ALV-induced lymphoid leukosis. Nature, 290:475-480.
41. Hendrix, M.J.C., Seftor, E.A., Grogan, T.M., Seftor, R.E.B., Hersh, E.M., Boyse, E.A., Liotta, L.A., Stetler-Stevenson, W., and Ray, C.G. (1992) Expression of type-IV collagenase correlates with the invasion of human lymphoblastoid cell lines and pathogenesis in SCID mice. Mol. Cell Probe., 6:59-65.
42. Huffnagle, G.B., Strieter, R.M., Standiford, T.J., Mcdonald, R.A., Burdick, M.D., Kunkel, S.L., and Toews, G.B. (1995) The role of monocyte chemotactic protein-1 (MCP-1) in the recruitment of monocytes and CD4(+) T cells during a pulmonary Cryptococcus neoformans infection. J. Immunol., 155:4790-4797.
43. Kobayashi, M., Hamada, J., Li, Y.Q., Shinobu, N., Imamura, M., Okada, F., Takeichi, N., and Hosokawa, M. (1995) A possible role of 92 kDa type IV collagenase in the extramedullary tumor formation in leukemia. Jpn. J. Cancer Res., 86:298-303.
44. Koka, P., van de Mark, K.A., and Faller, D.V. (1991) Trans-activation of genes encoding activation-associated human T lymphocyte surface proteins by murine retroviral sequences. J. Immunol., 146:2417-2425.
45. Kuratsu, J., Leonard, E., and Yoshimura, T. (1989) Production and characterization of human glioma-cell derived monocyte chemotactic factor. J. Nat. Cancer Inst., 81:347-351.
46. Lee, J.C., and Ihle, J.N. (1981) Chronic immune stimulation is required for Moloney leukemia virus-induced lymphomas. Nature, 289:407-409.
47. Lenz, J., Celander, D., Crowther, R.L., Patarca, R., Perkins, D.W., and Haseltine, W.A. (1984) Determination of the leukaemogenicity of a murine retrovirus by sequences within the long terminal repeat. Nature, 308:467-470.
48. Li, J., and Baltimore, D. (1991) Mechanisms of leukemogenesis induced by mink cell focus-forming murine leukemia viruses. J. Virol., 65:2408-2414.
49. Loetscher, P., Scitz, M., Clarklewis, I., Baggiolini, M., and Moser, B. (1994) Monocyte chemotactic proteins MCP-1, MCP-2, and MCP-3 are major attractants for human CD4(+) and CD8(+) T lymphocytes. FASEB J., 8:1055-1060.
50. Lopata, M.A., Cleveland, D.W., and Sollner-Webb, B. (1984) High level transient expression of a CAT gene by DEAE-dextran mediated DNA transfection. Nucleic Acids Res., 12:5707-5717.
51. McGrath, M.S., and Weissman, I.L. (1979) AKR leukemogenesis: Identification and biological significance of thymic lymphoma receptors for AKR retroviruses. Cell, 17:65-75.
52. McGrath, M.S., Tamura, G., and Weissman, I.L. (1987) Receptor mediated leukemogenesis: Murine leukemia virus interacts with BCL1 lymphoma cell surface IgM. Mol. Cell Immunol., 3:227-242.
53. Merulo, D., Nimelstein, S.H., Jones, P.P., Lieberman, M., and McDevitt, H.O. (1978) Increased synthesis and expression of H-2 antigens on thymocytes as a result of radiation leukemia virus infection: A possible mechanism for H-2 linked control of virus-induced neoplasia. J. Exp. Med., 147:470-487.
54. Mundschau, L.J., and Faller, D.V. (1991) BALB/c-3T3 fibroblasts resistant to growth inhibition by interferon-β exhibit aberrant Platelet-Derived Growth Factor, Epidermal Growth Factor, and Fibroblast Growth Factor signal transduction. Mol. Cell Biol., 11:3148-3154.
55. Nakamura, K., Williams, I.R., and Kupper, T.S. (1995) Keratinocyte-derived monocyte chemoattractant protein 1 (MCP-1): Analysis in a transgenic model demonstrates MCP-1 can recruit dendritic and langerhans cells to skin. J. Invest. Dermatol., 105:635-643.
56. Negus, R.P.M., Stamp, G.W.H., Relf, M.G., Burke, F., Malik, S.T.A., Bernasconi, S., Allavena, P., Sozzani, S., Mantovani, A., and Balkwill, F.R. (1995) The detection and localization of monocyte chemoattractant protein-1 (MCP-1) in human ovarian cancer. J. Clin. Invest., 95:2391-2396.
57. Nicolson, G.L. (1988) Cancer metastasis: Tumor cell and host organ properties important in metastasis to specific secondary sites. Biochem. Biophys. Acta., 948:175-224.
58. O'Neill, H.C., McGrath, M.S., Allison, J.P., and Weissman, I.L. (1987) A subset of T cell receptors associated with L3T4 molecules mediates C6VL leukemia cell binding of its cognate receptor. Cell, 49:143-151.
59. Orr, F., Adamson, I., and Young, L. (1985) Pulmonary inflammation generates chemotactic activity for tumor cells and promotes lung metastasis. Am. Rev. Resp. Dis., 131:607-611.
60. Pak, J., and Faller, D.V. (1996) Constitutive activation of transcription factor NFκB by murine leukemia virus infection. J. Virol., 70:4167-4172.
61. Petrarca, M.A., Reiss, C.S., Diamond, D.C., Boni, J., Burakoff, S.J., and Faller, D.V. (1988) T cell hybridomas define the class II MHC-restricted response to vesicular stomatitis virus infection. Microbial Pathogenesis, 5:319-332.
62. Prestidge, D.S. (1991) Signal Scan: A computer program that scans DNA sequences for eukaryotic transcription elements. CABIOS, 7:203-206.
63. Qin, S.X., LaRosa, G., Campbell, J.J., SmithHeath, H., Kassam, N., Shi, X.J., Zeng, L., Butcher, E.C., and Mackay, C.R. (1996) Expression of monocyte chemoattractant protein-1 and interleukin-8 receptors on subsets of T cells: Correlation with transendothelial chemotactic potential. Eur. J. Immunol., 26:640-647.
64. Rand, M.L., Warren, J.S., Mansour, M.K., Newman, W., and Ringler, D.J. (1996) Inhibition of T cell recruitment and cutaneous delayed-type hypersensitivity-induced inflammation with antibodies to monocyte chemoattractant protein-1. Am. J. Pathol., 148:855-864.
65. Rollins, B.J., Morrison, E.D., and Stiles, C.D. (1988) Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties. Proc. Natl. Acad. Sci. USA, 85:3738-3742.
66. Rollins, B.J., Stier, P., Ernst, T., and Wong, G.C. (1989) The human homolog of the JE gene encodes a monocyte secretory protein. Mol. Cell Biol., 9:4687-4695.
67. Rommelaere, J., Faller, D.V., and Hopkins, N. (1978) Characterization and mapping of RNase T1-resistant oligonucleotides derived from the genomes of Akv and MCF murine leukemia viruses. Proc. Natl. Acad. Sci. USA, 75:495-499.
68. Rosl, F., Lengert, M., Albrecht, J., Kleine, K., Zawatzky, R., Schraven, B., and Zur Hausen. H. (1994) Differential regulation of the JE gene encoding the monocyte chemoattractant protein (MCP-1) in cervical carcinoma cells and derived hybrids. J. Virol., 68:2142-2150.
69. Rovin, B.H., Yoshiumura, T., and Tan, L. (1992) Cytokine-induced production of monocyte chemoattractant protein-1 by cultured human mesangial cells. J. Immunol., 148:2148-2153.
70. Rovin, B.H., Dickerson, J.A., Tan, L.C., and Hebert, C.A. (1995) Activation of nuclear factor-kappa B correlates with MCP-1 expression by human mesangial cells. Kidney Int., 48:1263-1271.
71. Rudenstam, C. (1968) Experimental studies on trauma and metastasis formation. Acta Chir. Scand. Suppl., 391:1-83.
72. Shen-Ong, G.L., and Wolff, L. (1987) Moloney murine leukemia virus-induced myeloid tumors in adult BALB/c mice; Requirement of c-myb activation but lack of v-abl involvement. J. Virol., 61:3721-3725.
73. Shinnick, T.M., Lerner, R.A., and Sutcliffe, J.C. (1981) Nucleotide sequence of Moloney murine leukemia virus. Nature, 293:543.
74. Shyy, Y.J., Lin, M.C., Han, J.H., Lu, Y.J., Petrime, M., and Chien, S. (1995) The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression. Proc. Natl. Acad. Sci. USA, 92:8069-8073.
75. Shyy, Y.J., Li, Y.S., and Kolattukudy, P.E. (1993) Activation of MCP-1 gene expression is mediated through multiple signaling pathways. Biochem. Biophys. Res. Commun., 192:693-699.
76. Southern, P.J., and Berg, P. (1982) Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. J. Mol. Appl. Genet., 1:327-341.
77. Speck, N.A., Renjifo, B., Golemia, E., Fredrickson, T.N., Hartley, J.W., and Hopkins, N. (1990) Mutation of the core or adjacent LVb elements of the Moloney murine leukemia virus enhancer alters disease specificity. Gene Develop., 4:233-242.
78. Takeshima, H., Kuratsu, J., Takeya, M., Yoshimura, T., and Ushio, Y. (1994) Expression and localization of messenger RNA and protein for monocyte chemoattractant protein-1 in human malignant glioma. J. Neurosurg., 80:1056-1062.
79. Takeshita, A., Hanazawa, S., Amano, S., Matumoto, T., and Kitano, S. (1993) IL-1 induces expression of monocyte chemoattractant JE in clonal mouse osteoblastic cell line MC3T3-E1. J. Immunol., 150:1554-1562.
80. Takeshita, A., Chen, Y., Watanabe, A., Kitano, S., and Hanazawa, S. (1995) TGF-beta induces expression of monocyte chemoattractant JE/Monocyte chemoattractant protein 1 via transcriptional factor AP-1 induced by protein kinase in osteoblastic cells. J. Immunol., 155:419-426.
81. Taub, D.D., Proost, P., Murphy, W.J., Anver, M., Longo, D.L., Vandamme, J., and Oppenheim, J.J. (1995a) Monocyte chemotactic protein-1 (MCP-1), -2, and -3 are chemotactic for human T lymphocytes - Rapid publication. J. Clin. Invest., 95:1370-1376.
82. Taub, D.D., Savers, T.J., Carter, C.R., and Ortaldo, J.R. (1995b) Alpha and beta chemokines induce NK cell migration and enhance NK-mediated cytolysis. J. Immunol., 155:3877-3888.
83. Taubman, M.B., Rollins, B.J., Poon, M., Marmur, J., Green, M.S., Berk, B.C., and Nadalginard, B. (1992) JE messenger RNA accumulates rapidly in aortic injury and in platelet-derived growth factor-stimulated vascular smooth muscle cells. Circ. Res., 70:314-325.
84. Timmers, H.T.M., Pronk, G.J., Bos, J.L., and van der Eb, A.J. (1990) Analysis of rat JE gene promoter identifies an AP-1 binding site essential for basal expression but not for TPA induction. Nucleic Acids Res., 18:23-34.
85. Villiger, P.M., Terkeltaub, R., and Lotz, M. (1992) Monocyte chemoattractant protein-1 (MCP-1) expression in human articular cartilage - Induction by peptide regulatory factors and differential effects of dexamethasone and retinoic acid. J. Clin. Invest., 90:488-496.
86. Wakabayashi, H., Cavanaugh, P.G., and Nicolson, G.L. (1995) Purification and identification of mouse lung microvessel endothelial cell-derived chemoattractant for lung-metastasizing murine RAW117 large-cell lymphoma cells: Identification as mouse monocyte chemotactic protein 1. Cancer Res., 55:4458-4464.
87. Wang, D.L., Wung, B.S., Shyy, Y.J., Lin, C.F., Chao, Y.J., Usami, S., and Chien, S. (1995) Mechanical strain induces monocyte chemotactic protein-1 gene expression in endothelial cells - Effects of mechanical strain on monocyte adhesion to endothelial cells. Circ. Res., 77:294-302.
88. Watanabe, H., Nakanishi, I., Yamashita, K., Hayakawa, T., and Okada, Y. (1993) Matrix metalloproteinase-9 (92 kDa Gelatinase/ Type-IV Collagenase) from U937 monoblastoid cells - Correlation with cellular invasion. J. Cell Sci., 104:991-999.
89. Weeks, B.S., Klotman, M.E., Holloway, E., Stetlerstevenson, W.G., Kleinman, H.K., and Klotman, P.E. (1993) HIV-1 infection stimulates T-cell invasiveness and synthesis of the 92-kDa type-IV collagenase. AIDS Res. Hum. Retroviruses, 9:513-518.
90. Weng, H.Q., Choi, S.Y., and Faller, D.V. (1995) The Moloney leukemia retroviral long terminal repeat trans-activates AP-1-inducible genes and AP-1 transcription factor binding. J. Biol. Chem., 270:13637-13644.
91. Wilson, L.D., Flyer, D.C., and Faller, D.V. (1987) Murine retrovirus control class I MHC expression via a trans effect at the transcriptional level. Mol. Cell Biol., 7:2406-2415.
92. Wolff, L., and Ruscetti, S. (1988) The spleen focus-forming virus (SFFV) envelope gene, when introduced into mice in the absence of other SFFV genes, induces acute erythroleukemia. J. Virol., 62:2158-2163.
93. Wu, S., Boyer, C.M., Whitaker, R.S., Berchuck, A., Wiener, J.R., Weinberg, J.B., and Bast, R.C., Jr. (1993) Tumor necrosis factor alpha as an autocrine and paracrine growth factor for ovarian cancer: Monokine induction of tumor cell proliferation and tumor necrosis factor alpha expression. Cancer Res., 53:1939-1944.
94. Yoshimura, T., and Leonard, E.J. (1990) Secretion by human fibroblasts of monocyte chemoattractant protein-1, the product of gene JE. J. Immunol., 144:2377-2383.