Limited efficacy of gene transfer in herpes simplex virus-thymidine kinase/ganciclovir gene therapy for brain tumors

Journal of Neurosurgery

Volumn 102, Issue 2, 2005, Pages 328-335

  Hadaczek, Piotr ^a,b   Mirek, Hanna ^a   Berger, Mitchel S ^a   Bankiewicz, Krystof ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adenoassociated virus; Convection enhanced delivery; Ganciclovir; Gene therapy; Glioma; Thymidine kinase

Indexed keywords

ADENOVIRUS VECTOR; GANCICLOVIR; PHOSPHATE BUFFERED SALINE; THYMIDINE KINASE;

ADENOVIRUS 2; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; BRAIN TUMOR; CANCER CHEMOTHERAPY; CANCER SURVIVAL; CELL GROWTH; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG DISTRIBUTION; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE TRANSFER; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RAT STRAIN; SURVIVAL TIME; TUMOR VOLUME; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; ADENO ASSOCIATED VIRUS; ANIMAL; BRAIN; CANCER TRANSPLANTATION; GENETICS; GLIOBLASTOMA; NUDE RAT; PATHOLOGY; PHYSIOLOGY; SUICIDE TRANSGENE; THERMODYNAMICS; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; BRAIN; BRAIN NEOPLASMS; CELL LINE, TUMOR; CONVECTION; DEPENDOVIRUS; GANCICLOVIR; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, TRANSGENIC, SUICIDE; GLIOBLASTOMA; HUMANS; MALE; NEOPLASM TRANSPLANTATION; RATS; RATS, NUDE; SIMPLEXVIRUS; THYMIDINE KINASE; TRANSPLANTATION, HETEROLOGOUS;

EID: 14844304756     PISSN: 00223085     EISSN: 00223085     Source Type: Journal    
DOI: 10.3171/jns.2005.102.2.0328     Document Type: Article

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