Adeno-associated virus vector containing the herpes simplex virus thymidine kinase gene causes complete regression of intracerebrally implanted human gliomas in mice, in conjunction with ganciclovir administration

Japanese Journal of Cancer Research

Volumn 89, Issue 1, 1998, Pages 76-80

  Mizuno, Masaaki ^a   Yoshida, Jun ^a   Colosi, Peter ^b   Kurtzman, Gary ^b  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Avigen Inc   (United States)

Author keywords

AAV; GCV; Gene therapy; Glioma; HSV tk

Indexed keywords

GANCICLOVIR; THYMIDINE KINASE; VIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; GENE THERAPY; GENETIC TRANSDUCTION; GLIOMA; HERPES VIRUS SAIMIRI; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0031890022     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.1998.tb00482.x     Document Type: Article

References (15)

1. Berns, K. I. and Bohenzky, R. A. Adeno-associated viruses: an update. Adv. Virus Res., 32, 243-306 (1987).
2. Buller, R. M. L., Janik, J. E., Sebring, E. D. and Rose, J. A. Herpes simplex virus types 1 and 3 completely help adenovirus-associated virus replication. J. Virol., 40, 241-247 (1981).
3. Janik, J. E., Huston, M. M. and Rose, J. A. Locations of adenovirus genes required for the replication of adeno-associated virus. Proc. Natl. Acad. Sci. USA, 78, 1925-1930 (1981).
4. Moolten, F. L. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res., 46, 5276-5281 (1986).
5. Culver, K. W., Ram, Z., Wallbridge, S., Ishii, H., Oldfield, E. H. and Blaese, R. M. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science, 256, 1550-1552 (1992).
6. Blaese, R. M. Suicide genes. Task Force Rev., 6, 5 (1995).
7. Black, P. M. Brain tumors. N. Engl. J. Med., 324, 1555-1564 (1991).
8. Colosi, P., Ellinger, S., Ellinger, C. and Kurtzman, G. AAV vectors can be efficiently produced without helper virus. Blood, 86 (Suppl. 1), 2469 (1995).
9. Russell, D. W., Miller, A. D. and Alexander, I. E. Adeno-associated virus vectors preferentially transduce cells in S phase. Proc. Natl. Acad. Sci. USA, 91, 8915-8919 (1994).
10. Podsakoff, G., Wong, K. K., Jr. and Chatterjee, S. Efficient gene transfer into nondividing cells by adeno-associated virus-based vectors. J. Virol., 68, 5656-5666 (1994).
11. Okada, H., Miyamura, K., Itoh, T., Hagiwara, M., Wakabayashi, T., Mizuno, M., Colosi, P., Kurtzman, G. and Yoshida J. Gene therapy against an experimental glioma using adeno-associated virus vectors. Gene Ther., 3, 957-964 (1996).
12. Cool, V., Pirotte, B., Gerard, C., Dargent, J.-L., Baudson, N., Levivier, M., Goldman, S., Hildebrand, J., Brotchi, J. and Velu, T. Curative potential of herpes simplex virus thymidine kinase gene transfer in rats with 9L gliosarcoma. Hum. Gene Ther., 7, 627-635 (1996).
13. Freedman, S. M., Abboud, C. N., Wartenby, K. A., Packman, C. H., Koeplin, D. S., Moolten, F. L. and Abraham, G. N. The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res., 53, 5274-5283 (1993).
14. Samejima, Y. and Meruelo, D. Bystander killing induces apoptosis and is inhibited by forskolin. Gene Ther., 2, 50-58 (1995).
15. Bi, W. L., Parysek, L. M., Warnick, R. and Stanbrook, P. J. In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSVrk retroviral gene therapy. Hum. Gene Ther., 4, 725-731 (1993).