A potent sorbitol dehydrogenase inhibitor exacerbates sympathetic autonomic neuropathy in rats with streptozotocin-induced diabetes

Experimental Neurology

Volumn 192, Issue 2, 2005, Pages 407-419

  Schmidt, Robert E ^a   Dorsey, Denise A ^a   Beaudet, Lucie N ^a   Parvin, Curtis A ^a   Yarasheski, Kevin E ^a   Smith, Samuel R ^a   Williamson, Joseph R ^d   Peterson, Richard G ^b   Oates, Peter J ^c  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY   (United States)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^d NONE

Author keywords

Diabetic neuropathy; Sorbitol pathway; Sympathetic neuroaxonal dystrophy

Indexed keywords

CP 470711; FRUCTOSE; IDITOL DEHYDROGENASE; NERVE GROWTH FACTOR; OXIDOREDUCTASE INHIBITOR; SDI 711; SORBINIL; SORBITOL; UNCLASSIFIED DRUG; [4 [4 [2 (HYDROXYETHYL)PYRIMIDIN 4 YL]DIMETHYLPIPERAZIN 1 YL]PYRIMIDIN 2 YL]ETHANOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTONOMIC NEUROPATHY; CELL ULTRASTRUCTURE; CHRONIC DISEASE; CONTROLLED STUDY; DIABETIC NEUROPATHY; DISEASE COURSE; DISEASE EXACERBATION; DISEASE SEVERITY; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; EXPERIMENTAL MODEL; GENETIC MODEL; ILEUM; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MESENTERY; METABOLIC DISORDER; NEUROAXONAL DYSTROPHY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; STREPTOZOCIN DIABETES; STRUCTURE ANALYSIS; SYMPATHETIC GANGLION; TOXICITY TESTING; TREATMENT FAILURE;

EID: 14844296509     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.expneurol.2004.12.018     Document Type: Article

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