The NADH oxidase activity of the plasma membrane of synaptosomes is a major source of superoxide anion and is inhibited by peroxynitrite

Journal of Neurochemistry

Volumn 82, Issue 3, 2002, Pages 604-614

  Martín Romero, Francisco Javier ^a   Gutiérrez Martín, Yolanda ^a   Henao, Fernando ^a   Gutiérrez Merino, Carlos ^a  

^a UNIVERSITY OF EXTREMADURA   (Spain)

Author keywords

Coenzyme Q10; Cytochrome c; NADH oxidase; Peroxynitrite; Superoxide anion; Synaptic plasma membrane

Indexed keywords

ASCORBATE OXIDASE; ASCORBIC ACID; CYTOCHROME C; FREE RADICAL; PEROXYNITRITE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; SUPEROXIDE; THAPSIGARGIN; UBIDECARENONE; WHEAT GERM AGGLUTININ;

ANIMAL TISSUE; ARTICLE; BRAIN SYNAPTOSOME; CELL MEMBRANE; ENZYME ACTIVITY; MEMBRANE VESICLE; NERVE CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SYNAPTOSOME;

ANIMALS; ASCORBATE OXIDASE; ASCORBIC ACID; BRAIN CHEMISTRY; CELL MEMBRANE; CYTOCHROME C GROUP; ENZYME ACTIVATION; MULTIENZYME COMPLEXES; NADH, NADPH OXIDOREDUCTASES; PEROXYNITROUS ACID; RATS; RATS, WISTAR; SUPEROXIDES; SYNAPTOSOMES; UBIQUINONE;

ANIMALIA; PAPAYA MOSAIC VIRUS; TRITICUM AESTIVUM;

EID: 0036320426     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.00983.x     Document Type: Article

References (69)

1. Interactions between ascorbyl free radical and coenzyme Q at the plasma membrane
2. Cytochrome c is released from mitochondria in a reactive oxygen species (ROS)-dependent fashion and can operate as a ROS scavenger and as a respiratory substrate in cerebellar neurons undergoing excitotoxic death
3. Glutamate neurotoxicity, oxidative stress and mitochondria
4. Nitroblue tetrazolium reduction
5. Energetics in the pathogenesis of neurodegenerative diseases
6. Peroxynitrite versus hydroxyl radical: The role of nitric oxide in superoxide-dependent cerebral injury
7. ALS, SOD and peroxynitrite
8. Early release and subsequent caspase-mediated degradation of cytochrome c in apoptotic cerebellar granule cells
9. Nitric oxide-mediated mitochondrial damage in the brain: Mechanisms and implications for neurodegenerative diseases
10. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding
11. Synaptic signalling by nitric oxide
12. Early detection of DNA strand breaks in the brain after transient focal ischemia: Implications for the role of DNA damage in apoptosis and neuronal cell death
13. Catalase activity
14. Subcellular localization of biological molecules
15. Nitric oxide and oxygen radicals: A question of balance
16. Tissue, subcellular, and submitochondrial distributions of semidehydroascorbate reductase: Possible role of semidehydroascorbate reductase in cofactor regeneration
17. Peroxynitrite: An endogenous oxidizing and nitrating agent
18. Neuronal nitric oxide synthase activation and peroxynitrite formation in ischemic stroke linked to neural damage
19. Xanthine oxidase
20. Superoxide radical and superoxide dismutases
21. 2+-ATPase activity of rat brain synaptosomes
22. 2+-ATPase activity of synaptosomal plasma membrane by the local anaesthetics dibucaine and lidocaine
23. The site of production of superoxide radical in mitochondrial Complex I is not a bound ubisemiquinone but presumably iron-sulfur cluster N2
24. Orientation of synaptic plasma membrane vesicles containing calcium pump and sodium-calcium exchange activities
25. The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant
26. Mitochondria and apoptosis
27. Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed neuronal death
28. - pulses
29. Localization of the site of oxygen radical generation inside the complex I of heart and nonsynaptic brain mammalian mitochondria
30. The reaction of NO with superoxide
31. Methamphetamine generates peroxynitrite and produces dopaminergic neurotoxicity in mice: Protective effects of peroxynitrite decomposition catalyst
32. Peroxynitrite plays a role in methamphetamine-induced dopaminergic neurotoxicity: Evidence from mice lacking neuronal nitric oxide synthase gene or overexpressing copper-zinc superoxide dismutase
33. Coenzyme Q: Its role in scavenging and generation of radicals in membranes
34. Superoxide dismutase activity in organotypic midbrain-striatum co-cultures is associated with resistance of dopaminergic neurons to excitotoxicity
35. NAD (P) H, a directly operating antioxidant?
36. Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide
37. Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells
38. 5 in a single cell
39. Cytochrome c and dATP- dependent formation of Apaf-1/caspase 9 complex initiates an apoptotic protease cascade
40. DT-diaphorase: Purification, properties, and function
41. Role of plasma membrane coenzyme Q on the regulation of apoptosis
42. Selective induction of apoptosis by capsaicin in transformed cells: The role of reactive oxygen species and calcium
43. Inactivation of ecto-ATPase activity of rat brain synaptosomes
44. Inhibition of oxidative stress produced by plasma membrane NADH oxidase delays low-potassium induced apoptosis of cerebellar granule cells
45. Is ascorbic acid an antioxidant for the plasma membrane?
46. Ascorbate is the major electron donor for a transmembrane oxidoreductase of human erythrocytes
47. 2+-dependent ATPase in rat brain synaptosomes, synaptic membranes, and microsomes
48. Cerebrospinal fluid nitrite/nitrate levels in neurologic diseases
49. Peroxynitrite: A biologically significant oxidant
50. Vitamin E and selenium deficiency induces expression of the ubiquinone-dependent antioxidant system at the plasma membrane
51. Peroxynitrite reactions and diffusion in biology
52. Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide
53. Unraveling peroxynitrite formation in biological systems
54. Production of reactive oxygen species and release of 1-glutamate during superoxide anion-induced cell death of cerebellar granule neurons
55. Oxidation of ubiquinol by peroxynitrite: Implications for protection of mitochondria against nitrosative damage
56. Ascorbate-mediated transmembrane electron transport and ascorbate uptake in leukaemic cell lines are two different processes
57. Direct spectrophotometric detection of ascorbate free radical formed by dopamine beta-monooxygenase and by ascorbate oxidase
58. Oxidative chemistry of nitric oxide: The roles of superoxide, peroxynitrite and carbon dioxide
59. Synthesis of peroxynitrite in a twophase system using isoamyl nitrite and hydrogen peroxide
60. Role of oxidative stress in the apoptotic cell death of cultured cerebellar granule cells
61. Erythrocytes reduce extracellular ascorbate free radicals using intracellular ascorbate as an electron donor
62. Assay of succinate dehydrogenase
63. NADH-ascorbate free radical and -ferricyanide reductase activities represent different levels of plasma membrane electron transport
64. Role of transplasma membrane redox system in cell protection against oxidative stress
65. Single extraction method for the spectrophotometric quantification of oxidized and reduced pyridine nucleotides in erythrocytes
66. Dehydroascorbate reduction
67. Concentrations of metabolites in animal tissues
68. Apoptosis induced by inhibitors of the plasma membrane NADH-oxidase involves Bcl-2 and calcineurin