Distinct nongenomic signal transduction pathways controlled by 17β-estradiol regulate DNA synthesis and cyclin D1 gene transcription in HepG2 cells

Molecular Biology of the Cell

Volumn 13, Issue 10, 2002, Pages 3720-3729

  Marino, Maria ^a   Acconcia, Filippo ^a   Bresciani, Francesco ^a   Weisz, Alessandro ^a   Trentalance, Anna ^a  

^a ROMA TRE UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; ANTIESTROGEN; CYCLIN D1; DNA; ESTRADIOL; FULVESTRANT; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOLIPASE C INHIBITOR; PROTEIN KINASE C INHIBITOR; UO 126; ESTROGEN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; PRKCA PROTEIN, HUMAN; PROTEIN KINASE C; PROTEIN KINASE C ALPHA;

ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVATION; GENETIC TRANSCRIPTION; HELA CELL; HEPATOMA CELL; HORMONAL REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; BIOSYNTHESIS; CELL CULTURE; GENE EXPRESSION REGULATION; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN TRANSPORT; PROTO ONCOGENE; REPORTER GENE;

DNA; ENZYME ACTIVATION; ESTRADIOL; GENE EXPRESSION REGULATION; GENES, BCL-1; GENES, REPORTER; HUMANS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTEIN TRANSPORT; RECEPTORS, ESTROGEN; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0036799626     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E02-03-0153     Document Type: Article

References (46)

1. 1-arrested human breast cancer cell. Oncogene 12, 2315-2324.
2. Archer, T.K., Tam, S.P., and Deeley, R.G. (1986). Kinetics of estrogen-dependent modulation of apolipoprotein A-I synthesis in human hepatoma cells. J. Biol. Chem. 261, 5067-5074.
3. Archer, T.K., Tam, S.P., Deugau, K.V., and Deeley, R.G. (1985). Apolipoprotein C-II mRNA levels in primate liver. Induction by estrogen in the human hepatocarcinoma cell line, HepG2. J. Biol. Chem. 260, 1676-1681.
4. Augereau, P., Miralles, F., Cavailles, V., Gaudelet, C., Parker, M., and Rochefort, H. (1994). Characterization of the proximal estrogen-responsive element of human cathepsin D gene. Mol. Endocrinol. 8, 693-703.
5. Bradford, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Ann. Biochem. 772, 248-254.
6. Castoria, G., Barone, M.V., Di Domenico, M., Bilancio, A., Ametrano, D., Migliaccio, A., and Auricchio, F. (1999). Non-transcriptional action of estradiol and progestin triggers DNA synthesis. EMBO J. 18, 2500-2510.
7. Castoria, G., Migliaccio, A., Bilancio, A., Di Domenico, M., de Falco, A., Lombardi, M., Fiorentino, R., Varricchio, L., Barone, M.V., and Auricchio, F. (2001) PI3-kinase in concert with Src promotes the S-phase entry of estradiol-stimulated MCF-7 cells. EMBO J. 20, 6050-6059.
8. 1 gene expression in ZR-75 breast cancer cells involves multiple enhancer elements J. Biol. Chem. 276, 30853-30861.
9. Chen, J., Lavigne, J.A., Trush, M.A., and Yager, J.D. (1999). Increased mitochondrial superoxide production in rat liver mitochondria, rat hepatocytes, and HepG2 cells following ethinyl-estradiol treatment. Toxicol. Sci. 51, 224-235.
10. Coleman, K.M., and Smith, C.L. (2001). Intracellular signaling pathways, nongenomic actions of estrogens and ligand-independent activation of estrogen receptors. Frontiers Biosci. 6, d1379-d1391.
11. Dembinski, T.C., Leung, C.K., and Shiu, R.P. (1985). Evidence for a novel pituitary factor that potentiates the mitogenic effect of estrogen in human breast cancer cells. Cancer Res. 45, 3083-3089.
12. Di Croce, L., Bruscalupi, G., and Trentalance, A. (1996). Independent behavior of rat liver LDL receptor and HMGCoA reductase under estrogen treatment. Biochem. Biophys. Res. Commun. 16, 345-350.
13. Di Croce, L., Bruscalupi, G., and Trentalance, A. (1997). Independent responsiveness of frog liver low-density lipoprotein receptor and HMGCoA reductase to estrogen treatment. Pfluger Arch. 435, 107-111.
14. Di Croce, L., Vicent, G.P., Pecci, A., Bruscalupi, G., Trentalance, A., and Beato, M. (1999). The promoter of the rat 3-hydroxy-3-methyl-glutaryl coenzyme A reductase gene contains a tissue-specific estrogen-responsive region. Mol. Endocrinol. 13, 29-43.
15. Distefano, E., Marino, M., Gillette, J.A., Hanstein, B., Pallottini, V., Brüning, J., Krone, W., and Trentalance, A. (2002). Role of tyrosine kinase-signaling in estrogen-induced LDL-receptor gene expression in HepG2 cells. Biochim. Biophys. Acta 1580, 145-149.
16. Farsetti, A., Moretti, F., Narducci, M., Misiti, S., Nanni, S., Andreoli, M., Sacchi, A., and Pontecorvi, A. (1998). Orphan receptor hepatocyte nuclear factor-4 antagonises estrogen receptor a-mediated induction of human coagulation factor XII gene. Endocrinology 139, 4581-4589.
17. Fisher, B., Gunduz, N., Saffer, E.A., and Zheng, S. (1984). Relation of estrogen and its receptor to rat liver growth and regeneration. Cancer Res. 44, 2410-2415.
18. Foster, J.S., and Wimalasena, J. (1996). Estrogen regulates activity of cyclin-dependent kinases and retinoblastoma protein phosphorylation in breast cancer cells. Mol. Endocrinol. 10, 488-498.
19. Foster, J.S., Henley, D.C., and Ahamed, S. (2001). Estrogens, and cell-cycle regulation in breast cancer. Trends Endocrinol. Metabol. 12, 320-327.
20. Graf, G.A., Roswell, K.L., and Smart, E.J. (2001). 17β-Estradiol promotes the up-regulation of SR-BII in HepG2 cells, and in rat liver. J. Lipid Res. 42, 1444-1449.
21. 1 promoter. Oncogene 9, 1295-1304.
22. Jakacka, M., Ito, M, Weiss, J., Chien, P.Y., Gehm, B.D., and Jameson, J.L. (2001) Estrogen receptor binding to DNA is not required for its activity through the nonclassical AP-1 pathway. J. Biol. Chem. 276, 13615-13621.
23. Kelly, M.J., and Levin, E.R. (2001). Rapid actions of plasma membrane estrogen receptors. Trends Endocrinol. Metab. 12, 152-156.
24. Kousteni, S., et al. (2001) Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity. Cell 104, 719-790.
25. Liu, M.-M., Albanese, C., Anderson, C.M., Hilty, K., Webb, P., Uht, R.M., Price, R.H. Jr., Pestell, R.G., and Kushner, P.J. (2002) Opposing action of estrogen receptors α, and β on cyclin D1 gene expression. J. Biol. Chem., in press.
26. 3 mediate the estrogen receptor activity expressed in human cells. Mol. Cell. Endocrinol. 182, 19-26.
27. Marino, M., Distefano, E., Pallottini, V., Caporali, S., Ceracchi, G., and Trentalance, A. (2001a). β-Estradiol stimulation of DNA synthesis requires different PKC isoforms in HepG2, and MCF7 cells. J. Cell. Physiol. 188, 170-177.
28. Marino, M., Mele, R., Spagnuolo, S., Pulcinelli, F.M., Mangiantini, M.T., and Leoni, S. (2000). EGF regulates aminoacid transport in chick embryo hepatocytes via protein kinase C-ε. Exp. Physiol. 85, 363-369.
29. 3-PKC-α signal transduction in HepG2 cells. Biochem. Biophys. Res. Commun. 245, 254-258.
30. McEwen, B.S., and Alves, S.E. (1999). Estrogen actions in the central nervous system. Endocrinol. Rev. 20, 279-307.
31. 1 gene is mediated by multiple cis-elements, including SP1 sites, and a cAMP-responsive element in vascular endothelial cells. J. Biol. Chem. 276, 662-669.
32. Nilsson, S., Makela, S., Treuter, E., Tujague, M., Thomsen, J., Andersson, G., Enmark, E., Pettersson, K., Warner, M., and Gustafsson, J.A. (2001). Mechanisms of estrogen action. Physiol. Rev. 81, 1535-1565.
33. Norfleet, A.M., Clarke, C.H., Gametchu, B., and Watson, C. (2000). Antibodies to the estrogen receptor-alpha; modulate rapid prolactin release from rat pituitary tumor cells through plasma membrane estrogen receptor. FASEB J. 14, 157-165.
34. 1 expression and decreased cyclin-dependent kinase inhibitor association with cyclin E-Cdk2. J. Biol. Chem. 272, 10882-10894.
35. Razandi, M., Pedream, A., Greene, G., and Levin, E.R. (1999). Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ERα and ERβ expressed in Chinese Hamster ovary cells. Mol. Endocrinol. 13, 307-319.
36. Roberts, J.M. (1999). Evolving ideas about cyclins. Cell 98, 129-132.
37. Russell, K.S., Haynes, M.P., Sinha, D., Clerisme, E., and Bender, J.R. (2000). Human vascular endothelial cells contain membrane binding sites for estradiol, which mediate rapid intracellular signaling. Proc. Natl. Acad. Sci. USA 97, 5930-5935.
38. Sabbah, M., Courilleau, D., Mester, J., and Redeuilh, G. (1999). Estrogen induction of the cyclin D1 promoter: involvement of a camp response-like element. Proc. Natl. Acad. Sci. USA 96, 11217-11222.
39. Simoncini, T., Hafezi-Moghadam, A., Brazil, D.P., Ley, K., Chin, W.W., and Liso, J.K. (2000). Interaction of oestrogen receptor with the regulatory subunit of phosphathidylinositol-3-OH kinase. Nature 407, 538-451.
40. Song, R.X.-D., McPherson, R.A., Adam, L., Bao, Y., Shupnik, M., Kumar, R., and Santen, R. (2002). Linkage of rapid estrogen action to MAPK activation by ERα-Shc pathway activation. Mol. Endocrinol. 16, 116-127.
41. Sutherland, R.L., Reddel, R.R., and Green, M.D. (1983). Effects of estrogens on cell proliferation and cell cycle kinetics: a hypothesis on the cell cycle effects of antiestrogens. Eur. J. Cancer Clin. Oncol. 19, 307-318.
42. Tam, S.P., Hachè, R.J.G., and Deeley, R.G. (1986). Estrogen memory effect in human hepatocytes during repeated cell division without hormone. Science 234, 1234-1237.
43. Watanabe, G., Lee, R.J., Albanese, C., Rainey, W.E., Balle, D., and Pestell, R.G. (1996). Angiotensin II activation of cyclin D1-dependent kinase activity. J. Biol. Chem. 271, 22570-22577.
44. Webb, P., et al. (1999). The estrogen receptor enhances AP-1 activity by two distinct mechanisms with different requirements for receptor transactivation functions. Mol. Endocrinol. 13, 1672-1685.
45. Yager, J.D., Roebuck, B.D., Paluszcyk, T.L., and Memoli, V.A. (1986). Effects of etinyl estradiol and tamoxifen on liver DNA turnover and new synthesis and appearance of gamma glutamyl transpeptidase-positive foci in female rats. Carcinogenesis 7, 2007-2014.
46. Zheng, J., Ali, A., and Ramirez, V.D. (1996). Steroids conjugated to bovine serum albumin as tools to demonstrate specific steroid neuronal membrane binding sites. J. Psychiatry Neurosci. 21, 187-197.