Multigenerational exposure to phytosterols in the mouse

Reproductive Toxicology

Volumn 19, Issue 4, 2005, Pages 535-540

  Ryökkynen, Ari ^a   Käyhkö, Ulla Riitta ^a   Mustonen, Anne Mari ^a   Kukkonen, Jussi V K ^a   Nieminen, Petteri ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Estradiol; Mouse; Mus musculus; Phytosterols; Reproduction; Sex organs; Testosterone; Sitosterol

Indexed keywords

ESTRADIOL; PHYTOSTEROL; SEX HORMONE; SITOSTEROL; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENITAL SYSTEM; HORMONE BLOOD LEVEL; MALE; MOUSE; NONHUMAN; ORGAN WEIGHT; POSTNATAL DEVELOPMENT; REPRODUCTION; TESTIS; UTERUS WEIGHT;

MUS MUSCULUS; MUSCULUS;

EID: 14644439262     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2004.09.003     Document Type: Article

References (21)

1. S. Frische, and H. Steinhart Occurence of hormonal active compounds in food: a review Eur Food Res Technol 209 1999 153 179
2. L. Tremblay, and G. van der Kraak Use of a series of homologous in vitro and in vivo assays to evaluate the endocrine modulating actions of β-sitosterol in rainbow trout Aquat Toxicol 43 1998 149 162
3. P. Spengler, W. Körner, and J.W. Metzger Substances with estrogenic activity in effluents of sewage treatment plants in southwestern Germany. 1. Chemical analysis Environ Toxicol Chem 20 2001 2133 2141
4. M.H. Moghadasian Pharmacological properties of plant sterols. In vivo and in vitro observations Life Sci 67 2000 605 615
5. R.A. Moreau, B.D. Whitaker, and K.B. Hicks Phytosterols, phytostanols, and their conjugates in foods: structural diversity, quantitative analysis, and health-promoting uses Prog Lipid Res 41 2003 457 500
6. T. Malini, and G. Vanithakumari Antifertility effects of β-sitosterol in male albino rats J Ethnopharmacol 35 1991 149 153
7. T. Malini, and G. Vanithakumari Effect of beta-sitosterol on uterine biochemistry: a comparative study with estradiol and progesterone Biochem Mol Biol Int 31 1993 659 668
8. V.A. Baker, P.A. Hepburn, S.J. Kennedy, P.A. Jones, L.J. Lea, and J.P. Sumpter Safety evaluation of phytosterol esters. Part 1. Assessment of oestrogenicity using a combination of in vivo and in vitro assays Food Chem Toxicol 37 1999 13 22
9. F.A. El Samannoudy, A.M. Shareha, S.A. Ghannudi, G.A. Gillaly, and S.A. El Mougy Adverse effects of phytoestrogens-7. Effect of beta-sitosterol treatment on follicular development, ovarian structure and uterus in the immature female sheep Cell Mol Biol 26 1998 255 266
10. D.L. MacLatchy, and G.J. van der Kraak The phytoestrogen β-sitosterol alters the reproductive endocrine status of goldfish Toxicol Appl Pharmacol 134 1995 305 312
11. T. Nakari, and K. Erkomaa Effects of phytosterols on zebrafish reproduction in multigeneration test Environ Poll 123 2003 267 273
12. D.H. Waalkens-Berendsen, A.P.M. Wolterbeek, M.V.W. Wijnands, M. Richold, and P.A. Hepburn Safety evaluation of phytosterol esters. Part 3. Two-generation reproduction study in rats with phytosterol esters - novel functional food Food Chem Toxicol 37 1999 683 696
13. P. Nieminen, A.-M. Mustonen, P. Päiväläinen, and J.V.K. Kukkonen Reproduction of the tundra vole (Microtus oeconomus) with dietary phytosterol supplement Food Chem Toxicol 42 2004 945 951
14. R.R. Berges, J. Windeler, H.J. Trampisch, and T. Senge Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia Lancet 345 1995 1529 1532
15. D.J. Sanders, H.J. Minter, D. Howes, and P.A. Hepburn The safety evaluation of phytosterol esters. Part 6. The comparative absorption and distribution of phytosterols in the rat Food Chem Toxicol 38 2000 485 491
16. M.T. Cerquira, M.M. Fry, and W.E. Connor The food and nutrient intakes of the tarahumara indians of Mexico Am J Clin Nutr 32 1979 905 915
17. P. Nieminen, A.-M. Mustonen, P. Lindström-Seppä, V. Kärkkäinen, H. Mussalo-Rauhamaa, and J.V.K. Kukkonen Phytosterols affect endocrinology and metabolism of the field vole (Microtus agrestis) Exp Biol Med 228 2003 188 193
18. M.-H. Wang, and F.S. vom Saal Maternal age and traits in offspring Nature 407 2000 469 470
19. A.B. Awad, M.S. Hartati, and C.S. Fink Phytosterol feeding induces alteration in testosterone metabolism in rat tissues J Nutr Biochem 9 1998 712 717
20. P. Nieminen, A.-M. Mustonen, P. Lindström-Seppä, J. Asikainen, H. Mussalo-Rauhamaa, and J.V.K. Kukkonen Phytosterols act as endocrine and metabolic disruptors in the European polecat (Mustela putorius) Toxicol Appl Pharmacol 178 2003 22 28
21. M.H. Whittaker, V.H. Frankos, A.P.M. Wolterbeek, and D.H. Waalkens-Berendsen Two-generation reproductive toxicity study of plant stanol esters in rats Regul Toxicol Pharmacol 29 1999 196 204