Two-generation reproductive toxicity study of plant stanol esters in rats

Regulatory Toxicology and Pharmacology

Volumn 29, Issue 2 I, 1999, Pages 196-204

  Whittaker, Margaret H ^a   Frankos, Vasilios H ^a   Wolterbeek, A P M ^b   Waalkens Berendsen, D H ^b  

^a ENVIRON INTERNATIONAL CORPORATION   (United States)

^b TNO   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID ESTER;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; BODY WEIGHT DISORDER; CALORIE; CONTROLLED STUDY; FEMALE; FOOD INTAKE; INFANT MORTALITY; LIPID ABSORPTION; LITTER SIZE; MALE; NONHUMAN; PLANT; PRIORITY JOURNAL; RAT; REPRODUCTIVE TOXICITY; SEX RATIO; SEXUAL BEHAVIOR;

ANIMALIA; BRASSICA NAPUS VAR. NAPUS; RATTUS NORVEGICUS;

EID: 0033046011     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1006/rtph.1999.1288     Document Type: Article

References (7)

1. Gylling, H., and Miettinen, T. A. (1993). Sterum cholesterol lowering by dietary sitostanol is associated with reduced absorption and synthesis of cholesterol and decreased transport of LDL apoprotein B in men with Type II diabetes. In Treatment of Severe Dyslipoproteinemia in the Prevention of Coronary Heart Disease (A. M. Gotto, Jr., M. Mancini, W. O. Richter, and P. Schwandt, Eds.), pp. 57-59. Karger, Basel.
2. Gylling, H., and Miettinen, T. A. (1994). Serum cholesterol and cholesterol and lipoprotein metabolism in hypercholesterolemic NIDDM patients before and during sitostanol ester-spread treatment. Diabetologia 37, 773-780.
3. Gylling, H., and Miettinen, T. A. (1996). Effects of inhibiting cholesterol absorption and synthesis on cholesterol and lipoprotein metabolism in hypercholesterolemic non-insulin-dependent diabetic men. J. Lipid. Res. 37, 1776-1785.
4. Miettinen, T. A., Puska, P., Gylling, H., Vanhanen, H., and Vartiainen, E. (1995). Reduction of serum cholesterol with sitostanolester spread in a mildly hypercholesterolemic population. N. Engl. J. Med. 333, 1308-1312.
5. Niinikoski, H., Viikar, J., and Palmu, T. (1997). Cholesterol-lowering effect and sensory properties of sitostanol ester spread in normocholesterolemic adults. Scand. J. Nutr. 41, 9-12.
6. Vanhanen, H. T., Blomqvist, S., Ehnholm, C., Hyvonen, M., Jauhiainen, M., Torsitila, I., and Biettinen, T. A. (1993). Serum cholesterol, cholesterol precursors, and plant sterols in hypercholesterolemic subjects with different apoE phenotypes during dietary sitostanol ester treatment. J. Lipid Res. 34, 1535-1544.
7. Vanhanen, H. T., Kajander, J., Lehtovirta, H., and Miettinen, T. A. (1994). Serum levels, absorption efficiency, fecal elimination, and synthesis of cholesterol during increasing doses of dietary sitostanol esters in hypercholesterolemic subjects. Clin. Sci. 87, 61-67.