Enteric nervous system

Current Opinion in Gastroenterology

Volumn 21, Issue 2, 2005, Pages 176-182

  Grundy, David ^a   Schemann, Michael ^b  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Enteric development; Enteric nervous system; Hirschsprung disease; Ion channels; Receptors; Sensory neurons

Indexed keywords

BONE MORPHOGENETIC PROTEIN; ENDOTHELIN B RECEPTOR; ION CHANNEL; PURINE P2X2 RECEPTOR; PURINE P2X3 RECEPTOR; SONIC HEDGEHOG PROTEIN;

AFTERHYPERPOLARIZATION; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; ELECTROPHYSIOLOGY; GASTROINTESTINAL DISEASE; GLIA CELL; HIRSCHSPRUNG DISEASE; HUMAN; INTESTINE INNERVATION; MOLECULAR MECHANICS; MOTONEURON; MUSCLE SPINDLE AFFERENT NERVE; NERVE EXCITABILITY; NEURAL CREST CELL; NEURAL STEM CELL; NONHUMAN; REVIEW; SENSORY NERVE CELL;

ANIMALS; ENTERIC NERVOUS SYSTEM; HUMANS; INTESTINES; NEURONS, AFFERENT; REFLEX;

EID: 14644420856     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mog.0000153315.28327.6e     Document Type: Review

References (75)

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5. Gianino S, Grider JR, Cresswell J, et al. GDNF availability determines enteric neuron number by controlling precursor proliferation. Development 2003; 130:2187-2198. This is an investigation of ENS anatomy and intestinal contractility in mice heterozygous for Ret, GFRalpha1, and Ret ligands. Although there were only mild reductions in neuron size and neuronal fiber counts in Ret +/- and Gfra1 +/- mice, they had striking problems with intestinal contractility and neurotransmitter release, demonstrating that Ret signaling is critical for both ENS structure and function.
6. Yan H, Bergner AJ, Enomoto H, et al. Neural cells in the esophagus respond to glial cell line-derived neurotrophic factor and neurturin, and are RET-dependent. Dev Biol 2004; 272:118-133. This study is a quantitative analysis of ENS development in the esophagus. The density of neurons in the esophagus of Ret-/- mice is about 25 times lower than that in Ret+/- or Ret+/+ mice, suggesting that the development of enteric neurons in all regions of the gastrointestinal tract is largely Ret dependent. The study also shows that GDNF and neurturin, but not artemin, influence neural crest cell migrations and neurite outgrowth.
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