Effects of FR173657, a non-peptide B2 antagonist, on kinin-induced hypotension, visceral and peripheral oedema formation and bronchoconstriction

British Journal of Pharmacology

Volumn 120, Issue 5, 1997, Pages 933-939

  Griesbacher, Thomas ^a   Legat, Franz J ^b  

^a UNIVERSITY OF GRAZ   (Austria)

^b Universitatsklinik fur Dermatologie und Venerologie   (Austria)

Author keywords

Blood pressure; Bradykinin antagonists; Bronchoconstriction; FR173657; Hypotension; Inflammation; Paw oedema; Plasma protein extravasation

Indexed keywords

3 (6 ACETAMIDO 3 PYRIDYL) N [N [2,4 DICHLORO 3 [(2 METHYL 8 QUINOLINYL)OXYMETHYL]PHENYL] N METHYLAMINOCARBONYLMETHYL]ACRYLAMIDE; BRADYKININ ANTAGONIST; CAPTOPRIL; HISTAMINE; KININ; PROTEIN; SEROTONIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHOSPASM; CONTROLLED STUDY; DUODENUM; EDEMA; EXTRAVASATION; FEMALE; GUINEA PIG; HYPOTENSION; INFLAMMATION; INTRAVENOUS DRUG ADMINISTRATION; LUNG INFLATION; LUNG PRESSURE; MALE; NONHUMAN; PANCREAS; PATHOPHYSIOLOGY; PAW EDEMA; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0031002974     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0700966     Document Type: Article

References (31)

1. ALLEN, T.H. & ORAHOVATS, P.D. (1948). Spectrophotometric measurement of traces of dye T-1824 by extraction with cellophane from blood serum and urine of normal dogs. Am. J. Physiol., 154, 27-38.
2. BARNES, P.J., CHUNG, K.F. & PAGE, C.P. (1988). Inflammatory mediators and asthma. Pharmacol. Rev., 40, 49-84.
3. BATHON, J.M. & PROUD, D. (1991). Bradykinin antagonists. Ann. Rev. Pharmacol. Toxicol., 31, 129- 162.
4. BHOOLA, K.D., ELSON, C.J. & DIEPPE, P.A. (1992). Kinins - key mediators in arthritis? Br. J. Rheumatol., 31, 509-518.
5. DRAY, A. & PERKINS, M.N. (1993). Bradykinin and inflammatory pain. Trends Neurosci., 16, 99-104.
6. FARMER, S.G. (1991). Role of kinins in airway diseases. Immunopharmacology, 22, 1-20.
7. FARMER, S.O., BURCH, R.M., MEEKER, S.A. & WILKINS, D.E. (1989). Evidence for a pulmonary B3 bradykinin receptor. Mol. Pharmacol, 36, 1-8.
8. GAMSE, R., HOLZER, P. & LEMBECK, F. (1980). Decrease of substance P in primary afferent neurones and impairment of neurogenic plasma extravasation by capsaicin. Br. J. Pharmacol., 68, 207-213.
9. GEPPETTI, P., BERTRAND, C, RICCIARDOLO, F.M.L. & NADEL, J.A. (1995). New aspects on the role of kinins in neurogenic inflammation. Can. J. Physiol. Pharmacol., 73, 843-847.
10. GRIESBACHER, T. & LEMBECK, F. (1992). Effects of the bradykinin antagonist, HOE 140, in experimental acute pancreatitis. Br. J. Pharmacol., 107, 356-360.
11. GRIESBACHER, T., RAINER, I. & GRIENGL, S. (1996). Contribution of 5-hydroxytryptamine release from mast cells to rat paw oedema induced by wasp venom and synthetic kinins. Br. J. Pharmacol., 117, 89P.
12. GRIESBACHER, T., TIRAN, B. & LEMBECK, F. (1993). Pathological events in experimental acute pancreatitis prevented by the bradykinin antagonist, Hoe 140. Br. J. Pharmacol., 108,405-411.
13. HALL, J.M. (1992). Bradykinin receptors: pharmacological properties and biological roles. Pharmacol. Ther., 56, 131-190.
14. HALL, J.M., FIGINI, M., BUTT, S.K. & GEPPETTI, P. (1995). Inhibition of bradykinin-evoked trigeminal nerve stimulation by the nonpeptide bradykinin B2 receptor antagonist WIN 64338 in vitro and in vivo. Br. J. Pharmacol., 116, 3164-3168.
15. HALL, J.M., MITCHELL, D., CHIN, S.Y., FIELD, J.L., EVERETT, CM. & MORTON, I.K.M. (1992). Differences in affinities of bradykinin B2 receptor antagonists may be attributable to species. Neuropeptides, 22, 28-29.
16. HOCK, F.J., WIRTH, K., ALBUS, U., LINZ, W., GERHARDS, H.J., WIEMER, G., HENKE, S., BREIPOHL, G., KÖNIG, W., KNOLLE, J. & SCHÖLKENS, B.A. (1991). Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br. J. Pharmacol., 102, 769-773.
17. INAMURA, N., ASANO, M., KAYAKIRI, H., HATORI, C., OKU, T. & NAKAHARA, K. (1996). Characterization of FR173657, a novel non-peptide BK2 antagonist, in vitro and in vivo studies. International Symposium 'Peptide Receptors', Montréal, Canada, 28 July- 1 August 1996.
18. LEGAT, F.J., GRIESBACHER, T. & LEMBECK, F. (1994). Mediation by bradykinin of rat paw oedema induced by collagenase from Clostridium histolylicum. Br. J. Pharmacol., 112, 453-460.
19. LEMBECK, F. & GRIESBACHER, T. (1996). Pathophysiological and possible physiological roles of kinins in the pancreas. Immunopharmacology, 33, 336-338.
20. LEMBECK, F., GRIESBACHER, T., ECKHARDT, M., HENKE, S., BREIPOHL, G. & KNOLLE, J. (1991). New, long-acting, potent bradykinin antagonists. Br. J, Pharmacol., 102, 297-304.
21. MAKEVNINA, L.G., LOMOVA, I.P., ZUBKOV, Y.N. & SEMENYUTIN, V.B. (1995). Kininogen consumption in cerebral circulation of humans during brain ischemia and postischemic reperfusion. Braz. J. Med. Biol. Res., 27, 1955-1963.
22. MARCEAU, F. (1995). Kinin B] receptors: a review. Immunopharmacology,30, 1-26.
23. REGOLI, D., JUKIC, D., GOBEIL, F. & RHALEB, N.-E. (1993). Receptors for bradykinin and related kinins: a critical review. Can. J. Physiol. Pharmacol., 71, 556-567.
24. SARIA, A. & LUNDBERG, J.M. (1983). Evans blue fluorescence: quantitative and morphological evaluation of vascular permeability in animal tissues. J. Neurosci. Meth., 8, 41-49.
25. 2 receptor. J. Med. Chem., 36, 2583-2584.
26. 2 receptor antagonist. Proc. Natl. Acad. Sei. U.S.A., 91, 4693-4697.
27. SAWUTZ, D.G., SALVINO, J.M., DOLLE, R.E., SEOANE, P.R. & FARMER, S.G. (1995). Pharmacology and structure-activity relationship of the nonpeptide bradykinin receptor antagonist WIN 64338. Can. J. Physiol. Pharmacol., 73, 805-811.
28. SHARMA, J.N. (1993). Therapeutic prospects of bradykinin receptor antagonists. Gen. Pharmacol., 24, 267-274.
29. STERANKA, L.R., MANNING, D.C., DEHAAS, C.J., FERKANY, J.W., BOROSKY, S.A., CONNOR, J.R., VAVREK, R.J., STEWART, J.M. & SNYDER, S.H. (1988). Bradykinin as a pain mediator: receptors localized to sensory neurons, and antagonists have analgesic actions. Proc. Natl. Acad. Sei. U.S.A., 85, 3245-3249.
30. WIRTH, K., HOCK, F.J., ALBUS, U., LINZ, W., ALPERMANN, H.G., ANAGNOSTOPOULOS, H., HENKE, S., BREIPOHL, G., KÖNIG, W., KNOLLE, J. & SCHÖLKENS, B.A. (1991). Hoe 140 a new potent and long acting bradykinin-antagonist: in vivo studies. Br. J. Pharmacol, 102, 774-777.
31. ZAR, J.H. (1984). Biostatistical Analysis. 2nd ed. Englewood Cliffs, N.J.: Prentice-Hall.