Differential functional interplay of TOGp/XMAP215 and the KinI kinesin MCAK during interphase and mitosis

EMBO Journal

Volumn 23, Issue 3, 2004, Pages 627-637

  Holmfeldt, Per ^a   Stenmark, Sonja ^a   Gullberg, Martin ^a  

^a UMEÅ UNIVERSITY   (Sweden)

Author keywords

Catastrophe; Monoastral; Pericentrin; RNA interference; XKCM1

Indexed keywords

KINESIN; KINI KINESIN; PROTEIN; PROTEIN MCAK; PROTEIN TOGP; PROTEIN XMAP215; RNA; UNCLASSIFIED DRUG;

ARTICLE; CELL POPULATION; CENTROMERE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERPHASE; LEUKEMIA CELL; MICROTUBULE; MITOSIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN SYNTHESIS; RNA INTERFERENCE; SOMATIC CELL;

HUMANS; INTERPHASE; K562 CELLS; KINESIN; MICROTUBULE-ASSOCIATED PROTEINS; MITOSIS; MITOTIC SPINDLE APPARATUS;

EID: 1442338341     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600076     Document Type: Article

References (31)

1. Baer M, Nilsen TW, Costigan C, Altman S (1990) Structure and transcription of a human gene for H1 RNA, the RNA component of human RNase P. Nucleic Acids Res 18: 97-103
2. Belmont LD, Hyman AA, Sawin KE, Mitchison TJ (1990) Real-time visualization of cell cycle-dependent changes in microtubule dynamics in cytoplasmic extracts. Cell 62: 579-589
3. Bornens M (2002) Centrosome composition and microtubule anchoring mechanisms. Curr Opin Cell Biol 14: 25-34
4. Brummelkamp TR, Bernards R, Agami R (2002) A system for stable expression of short interfering RNAs in mammalian cells. Science 296: 550-553
5. Cassimeris L, Gard D, Tran PT, Erickson HP (2001) XMAP215 is a long thin molecule that does not increase microtubule stiffness. J Cell Sci 114: 3025-3033
6. Charrasse S, Schroeder M, Gauthier-Rouviere C, Ango F, Cassimeris L, Gard DL, Larroque C (1998) The TOGp protein is a new human microtubule-associated protein homologous to the Xenopus XMAP215. J Cell Sci 111: 1371-1383
7. Desai A, Mitchison TJ (1997) Microtubule polymerization dynamics. Annu Rev Cell Dev Biol 13: 83-117
8. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T (2001) Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411: 494-498
9. Garcia MA, Koonrugsa N, Toda T (2002) Spindle-kinetochore attachment requires the combined action of Kin I-like Klp5/6 and Alp14/Dis1-MAPs in fission yeast. EMBO J 21: 6015-6024
10. Gard DL, Kirschner MW (1987) A microtubule-associated protein from Xenopus eggs that specifically promotes assembly at the plus-end. J Cell Biol 105: 2203-2215
11. Gergely F, Draviam VM, Raff JW (2003) The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells. Genes Dev 17: 336-341
12. Gradin HM, Larsson N, Marklund U, Gullberg M (1998) Regulation of microtubule dynamics by extracellular signals: cAMP-dependent protein kinase switches off the activity of oncoprotein 18 in intact cells. J Cell Biol 140: 131-141
13. Holmfeldt P, Brattsand G, Gullberg M (2002) MAP4 counteracts microtubule catastrophe promotion but not tubulin-sequestering activity in intact cells. Curr Biol 12: 1034-1039
14. Holmfeldt P, Brattsand G, Gullberg M (2003) Interphase and monoastral-mitotic phenotypes of overexpressed MAP4 are modulated by free tubulin concentrations. J Cell Sci 116: 3701-3711
15. Holmfeldt P, Larsson N, Segerman B, Howell B, Morabito J, Cassimeris L, Gullberg M (2001) The catastrophe-promoting activity of ectopic Op18/stathmin is required for disruption of mitotic spindles but not interphase microtubules. Mol Biol Cell 12: 73-83
16. Howard J, Hyman AA (2003) Dynamics and mechanics of the microtubule plus end. Nature 422: 753-758
17. Howell B, Deacon H, Cassimeris L (1999) Decreasing oncoprotein 18/stathmin levels reduces microtubule catastrophes and increases microtubule polymer in vivo. J Cell Sci 112: 3713-3722
18. Kinoshita K, Arnal I, Desai A, Drechsel DN, Hyman AA (2001) Reconstitution of physiological microtubule dynamics using purified components. Science 294: 1340-1343
19. Kinoshita K, Habermann B, Hyman AA (2002) XMAP215: a key component of the dynamic microtubule cytoskeleton. Trends Cell Biol 12: 267-273
20. Kline-Smith SL, Walczak CE (2002) The microtubule-destabilizing kinesin XKCM1 regulates microtubule dynamic instability in cells. Mol Biol Cell 13: 2718-2731
21. Ohkura H, Garcia MA, Toda T (2001) Dis1/TOG universal microtubule adaptors-one MAP for all? J Cell Sci 114: 3805-3812
22. Salmon ED, Leslie RJ, Saxton WM, Karow ML, McIntosh JR (1984) Spindle microtubule dynamics in sea urchin embryos: analysis using a fluorescein-labeled tubulin and measurements of fluorescence redistribution after laser photobleaching. J Cell Biol 99: 2165-2174
23. Segerman B, Holmfeldt P, Morabito J, Cassimeris L, Gullberg M (2003) Autonomous and phosphorylation-responsive microtubule-regulating activities of the N-terminus of Op18/stathmin. J Cell Sci 116: 197-205
24. Shao RG, Shimizu T, Pommier Y (1997) 7-Hydroxystaurosporine (UCN-01) induces apoptosis in human colon carcinoma and leukemia cells independently of p53. Exp Cell Res 234: 388-397
25. Shirasu-Hiza M, Coughlin P, Mitchison T (2003) Identification of XMAP215 as a microtubule-destabilizing factor in Xenopus egg extract by biochemical purification. J Cell Biol 161: 349-358
26. Spittle C, Charrasse S, Larroque C, Cassimeris L (2000) The interaction of TOGp with microtubules and tubulin. J Biol Chem 275: 20748-20753
27. Tournebize R, Popov A, Kinoshita K, Ashford AJ, Rybina S, Pozniakovsky A, Mayer TU, Walczak CE, Karsenti E, Hyman AA (2000) Control of microtubule dynamics by the antagonistic activities of XMAP215 and XKCM1 in Xenopus egg extracts. Nat Cell Biol 2: 13-19
28. Walczak CE, Mitchison TJ, Desai A (1996) XKCM1: a Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly. Cell 84: 37-47
29. van Breugel M, Drechsel D, Hyman A (2003) Stu2p, the budding yeast member of the conserved Dis1/XMAP215 family of microtubule-associated proteins is a plus end-binding microtubule destabilizer. J Cell Biol 161: 359-369
30. Vasquez RJ, Gard DL, Cassimeris L (1994) XMAP from Xenopus eggs promotes rapid plus end assembly of microtubules and rapid microtubule polymer turnover. J Cell Biol 127: 985-993
31. Vasquez RJ, Gard DL, Cassimeris L (1999) Phosphorylation by CDK1 regulates XMAP215 function in vitro. Cell Motil Cytoskeleton 43: 310-321