Autonomous and phosphorylation-responsive microtubule-regulating activities of the N-terminus of Op18/stathmin

Journal of Cell Science

Volumn 116, Issue 1, 2003, Pages 197-205

  Segerman, Bo ^a   Holmfeldt, Per ^a   Morabito, Justin ^b   Cassimeris, Lynne ^b   Gullberg, Martin ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b LEHIGH UNIVERSITY   (United States)

Author keywords

GTP phosphorydrolase; Microtubule; Oncoprotein 18; Phosphoprotein

Indexed keywords

GUANOSINE TRIPHOSPHATE; STATHMIN; TUBULIN;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; BINDING AFFINITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERPHASE; METAPHASE; MICROTUBULE ASSEMBLY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN HYDROLYSIS; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REVIEW; SOLUBILITY;

AMINO ACID SEQUENCE; CELL CYCLE; DIMERIZATION; EUKARYOTIC CELLS; GENE EXPRESSION; GUANOSINE TRIPHOSPHATE; HUMANS; HYDROLYSIS; INTERPHASE; METAPHASE; MICROTUBULE PROTEINS; MICROTUBULES; MITOSIS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STATHMIN; TUMOR CELLS, CULTURED;

EID: 0037242277     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.00205     Document Type: Review

References (32)

1. Arencibia, I., Suarez, N. C., Wolf-Watz, H. and Sundqvist, K. G. (1997). Yersinia invasin, a bacterial beta 1-integrin ligand, is a potent inducer of lymphocyte motility and migration to collagen type IV and fibronectin. J. Immunol. 159, 1853-1859.
2. Belmont, L. D. and Mitchison, T. J. (1996). Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules. Cell 84, 623-631.
3. Brattsand, G., Roos, G., Marklund, U., Ueda, H., Landberg, G., Nanberg, E., Sideras, P and Gullberg, M. (1993). Quantitative analysis of the expression and regulation of an activation-regulated phosphoprotein (oncoprotein 18) in normal and neoplastic cells. Leukemia 7, 569-579.
4. Carlier, M. F., Didry, D. and Pantaloni, D. (1997). Hydrolysis of GTP associated with the formation of tubulin oligomers is involved in microtubule nucleation. Biophys. J. 73, 418-427.
5. Cassimeris, L. (1999). Accessory protein regulation of microtubule dynamics throughout the cell cycle. Curr. Opin. Cell Biol. 11, 134-141.
6. Curmi, P. A., Andersen, S. S., Lachkar, S., Gavet, O., Karsenti, E., Knossow, M. and Sobel, A. (1997). The stathmin/tubulin interaction in vitro. J. Biol. Chem. 272, 25029-25036.
7. Desai, A. and Mitchison, T. J. (1997). Microtubule polymerization dynamics. Annu. Rev. Cell Dev. Biol. 13, 83-117.
8. Gigant, B., Curmi, P. A., Martin-Barbey, C., Charbaut, E., Lachkar, S., Lebeau, L., Siavoshian, S., Sobel, A. and Knossow, M. (2000). The 4 A X-ray structure of a tubulin:stathmin-like domain complex. Cell 102, 809-816.
9. Gradin, H. M., Larsson, N., Marklund, U. and Gullberg, M. (1998). Regulation of microtubule dynamics by extracellular signals: cAMP-dependent protein kinase switches off the activity of oncoprotein 18 in intact cells. J. Cell Biol. 140, 131-141.
10. Groger, R. K., Morrow, D. M. and Tykocinski, M. L. (1989). Directional antisense and sense cDNA cloning using Epstein-Barr virus episomal expression vectors. Gene 81, 285-294.
11. Holmfeldt, P, Larsson, N., Segerman, B., Howell, B., Morabito, J., Cassimeris, L. and Gullberg, M. (2001). The catastrophe-promoting activity of ectopic Op18/stathmin is required for disruption of mitotic spindles but not interphase microtubules. Mol. Biol. Cell 12, 73-83.
12. Holmfeldt, P., Brattsand, G. and Gullberg, M. (2002). MAP4 counteracts microtubule catastrophe-promotion, but not tubulin-sequestering activity, in intact cells. Curr. Biol. 12, 1034-1039.
13. Howell, B., Deacon, H. and Cassimeris, L. (1999a). Decreasing oncoprotein 18/stathmin levels reduces microtubule catastrophes and increases microtubule polymer in vivo. J. Cell Sci. 112, 3713-3722.
14. Howell, B., Larsson, N., Gullberg, M. and Cassimeris, L. (1999b). Dissociation of the tubulin-sequestering and microtubule catastrophe-promoting activities of oncoprotein 18/stathmin. Mol. Biol. Cell 10, 105-118.
15. Jourdain, L., Curmi, P., Sobel, A., Pantaloni, D. and Carlier, M. F. (1997). Stathmin: a tubulin-sequestering protein which forms a ternary T2S complex with two tubulin molecules. Biochemistry 36, 10817-10821.
16. Larsson, N., Melander, H., Marklund, U., Osterman, O. and Gullberg, M. (1995). G2/M transition requires multisite phosphorylation of oncoprotein 18 by two distinct protein kinase systems. J Biol. Chem. 270, 14175-14183.
17. Larsson, N., Marklund, U., Gradin, H. M., Brattsand, G. and Gullberg, M. (1997). Control of microtubule dynamics by oncoprotein 18: dissection of the regulatory role of multisite phosphorylation during mitosis. Mol. Cell. Biol. 17, 5530-5539.
18. Larsson, N., Segerman, B., Howell, B., Fridell, K., Cassimeris, L. and Gullberg, M. (1999). Op18/stathmin mediates multiple region-specific tubulin and microtubule- regulating activities. J. Cell Biol. 146, 1289-1302.
19. Lawler, S. (1998). Microtubule dynamics: if you need a shrink try stathmin/Op18. Curr. Biol. 8, R212-R214.
20. Marklund, U., Brattsand, G., Shingler, V. and Gullberg, M. (1993). Serine 25 of oncoprotein 18 is a major cytosolic target for the mitogen-activated protein kinase. J. Biol. Chem. 268, 15039-15047.
21. Marklund, U., Osterman, O., Melander, H., Bergh, A. and Gullberg, M. (1994). The phenotype of a "Cdc2 kinase target site-deficient" mutant of oncoprotein 18 reveals a role of this protein in cell cycle control. J. Biol. Chem. 269, 30626-30635.
22. Marklund, U., Larsson, N., Gradin, H. M., Brattsand, G. and Gullberg, M. (1996). Oncoprotein 18 is a phosphorylation-responsive regulator of microtubule dynamics. EMBO J. 15, 5290-5298.
23. 2+/calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18. Mol. Cell Biol. 17, 3459-3467.
24. Muller, D. R., Schindler, P, Towbin, H., Wirth, U., Voshol, H., Hoving, S. and Steinmetz, M. O. (2001). Isotope-tagged cross-linking reagents. A new tool in mass spectrometric protein interaction analysis. Anal. Chem. 73, 1927-1934.
25. Muller, U., Bossy, B., Venstrom, K. and Reichardt, L. F. (1995). Integrin alpha 8 beta 1 promotes attachment, cell spreading, and neurite outgrowth on fibronectin. Mol. Biol. Cell 6, 433-448.
26. Nogales, E. (2001). Structural insight into microtubule function. Annu. Rev. Biophys. Biomol. Struct. 30, 397-420.
27. Segerman, B., Larsson, N., Holmfeldt, P and Gullberg, M. (2000). Mutational analysis of op18/stathmin-tubulin-interacting surfaces. Binding cooperativity controls tubulin GTP hydrolysis in the ternary complex. J. Biol. Chem. 275, 35759-35766.
28. Simons, M., Wang, M., McBride, O. W., Kawamoto, S., Yamakawa, K., Gdula, D., Adelstein, R. S. and Weir, L. (1991). Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes. Circ. Res. 69, 530-539.
29. Steinmetz, M. O., Kammerer, R. A., Jahnke, W., Goldie, K. N., Lustig, A. and van Oostrum, J. (2000). Op18/stathmin caps a kinked protofilament-like tubulin tetramer. EMBO J. 19, 572-580.
30. Walczak, C. E. (2000). Microtubule dynamics and tubulin interacting proteins. Curr. Opin. Cell Biol. 12, 52-56.
31. Wallon, G., Rappsilber, J., Mann, M. and Serrano, L. (2000). Model for stathmin/OP18 binding to tubulin. EMBO J. 19, 213-222.
32. Vasquez, R. J., Gard, D. L. and Cassimeris, L. (1994). XMAP from Xenopus eggs promotes rapid plus end assembly of microtubules and rapid microtubule polymer turnover. J. Cell Biol. 127, 985-993.