Remodeling of the major mouse xenoantigen, Galα1-3Galβ1-4GlcNAc- R, by N-acetylglucosaminyltransferase-III

Molecules and Cells

Volumn 16, Issue 3, 2003, Pages 343-353

  Chung, Tae Wook ^a   Kim, Kyung Sook ^a   Kang, Sung Koo ^a   Lee, Jung Woong ^a,d   Song, Eun Young ^b   Chung, Tae Hwa ^c   Yeom, Young Il ^b   Kim, Cheorl Ho ^a  

^a Dongguk University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Research Laboratory   (South Korea)

^d The Catholic University of Korea   (South Korea)

Author keywords

GnT III; N Acetylglucosamine; N Glycosylation; Transgenic Mice; Xenotransplantation

Indexed keywords

ALBUMIN; ALPHA 1,3 GALACTOSYLTRANSFERASE; ALPHA 6 DEXTRO MANNOSIDE BETA 1,6 N ACETYLGLUCOSAMINYLTRANSFERASE V; BETA DEXTRO MANNOSIDE BETA 1,4 N ACETYLGLUCOSAMINYLTRANSFERASE III; EPITOPE; N ACETYLGLUCOSAMINE; N ACETYLGLUCOSAMINYLTRANSFERASE; UNCLASSIFIED DRUG; BETA 1,4 MANNOSYL GLYCOPROTEIN BETA 1,4 N ACETYLGLUCOSAMINYLTRANSFERASE; BETA-1,4-MANNOSYL-GLYCOPROTEIN BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE; HETEROPHILE ANTIGEN; OLIGOSACCHARIDE;

ANIMAL CELL; ANTIGENICITY; ARTICLE; CATALYSIS; CONTROLLED STUDY; CYTOLYSIS; ENDOTHELIUM CELL; ENZYME ACTIVITY; GENE OVEREXPRESSION; HUMAN; MOUSE; NATURAL KILLER CELL; NONHUMAN; TRANSGENIC MOUSE; XENOTRANSPLANTATION; ANIMAL; GENETICS; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; METABOLISM;

ANIMALIA; MUS MUSCULUS;

ANIMALS; ANTIGENS, HETEROPHILE; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, TRANSGENIC; N-ACETYLGLUCOSAMINYLTRANSFERASES; OLIGOSACCHARIDES;

EID: 1442307620     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. Bhaumik, M., Seldin, M. F., and Stanley, P. (1995) Cloning and chromosomal mapping of the mouse Mgat3 gene encoding N- acetylglucosaminyltransferase III. Gene 164, 295-300.
2. Chomczynski, P. and Sacchi, N. (1987) Single step method of RNA isolation by acid guanidnium thiocyanate-phenolchloroform extraction. Anal. Biochem. 162, 156-159.
3. Cohney, S., McKenzie, I. F., Patton, K., Prenzoska, J., Ostenreid, K., Fodor, W. L., and Sandrin, M. S. (1997) Down-regulation of Gal α(1,3)Gal expression by α1,2-fucosyltransferase: further characterization of α1,2-fucosyltransferase transgenic mice. Transplantation 64, 495-500.
4. Costa, C., Zhao, L., Burton, W. V., Bondioli, K. R., Williams, B. L., Hoagland, T. A., Ditullio, P. A., Ebert, K. M., and Fodor, W. L. (1999) Expression of the human α1,2-fucosyltransferase in transgenic pigs modifies the cell surface carbohydrate phenotype and confers resistance to human serum-mediated cytolysis. FASEB J. 13, 1762-1773.
5. Cummings, R. D. and Kornfeld, S. (1982) Characterization of structural determinants required for the high-affinity interaction of asparagine-linked oligosaccharides with immobilized Phaseolus vulgaris leukoagglutinating and erythroagglutinating lectins. J. Biol. Chem. 257, 11230-11234.
6. Dooldeniya, M. D. and Warrens, A. N. (2003) Xenotransplantation: where are we today? J. R. Soc. Med. 96, 111-117.
7. Egge, H., Kordowicz, M., Peter-Katalinic, J., and Hanfland, P. (1985) Immunochemistry of I/i-active oligo- and polyglycosylceramides from rabbit erythrocyte membranes. Characterization of linear, di-, and triantennary neolactoglycosphingolipids. J. Biol. Chem. 260, 4927-4935.
8. Fodor, W. L., Williams, B. L., Matis, L. A., Madri, J. A., Rollins, S. A., Knight, J. W., Velander, W., and Squinto, S. P. (1994) Expression of a functional human complement inhibitor in a transgenic pig as a model for the prevention of xenogeneic hyperacute organ rejection. Proc. Natl. Acad. Sci. USA 91, 11153-11157.
9. Galili, U. (2001) The alpha-gal epitope (Galα1-3Galβ1-4Glc NAc-R) in xenotransplantation. Biochimie 83, 557-563
10. Galili, U. and Swanson, K. (1991) Gene sequences suggest inactivation of α1,3-galactosyltransferase in catarrhines after the divergence of apes from monkeys. Proc. Natl. Acad. Sci. USA 88, 7401-7404.
11. Galili, U., Rachmilewitz, E. A., Peleg, A., and Flechner, I. (1984) A unique natural human IgG antibody with anti-alpha-galactosyl specificity. J. Exp. Med. 160, 1519-1531.
12. Galili, U., Clark, M. R., Shohet, S. B., Buehler, J., and Macher, B. A. (1987) Evolutionary relationship between the natural anti-Gal antibody and the Galα1-3Gal epitope in primates. Proc. Natl. Acad. Sci. USA 84, 1369-1373.
13. Hakomori, S. (1989) Aberrant glycosylation in tumors and tumor-associated carbohydrate antigens. Adv. Cancer Res. 52, 257-331.
14. Hase, S., Ibuki, T., and Ikenaka, T. (1984) Reexamination of the pyridylamination used for fluorescence labeling of oligosaccharides and its application to glycoproteins. J. Biochem. 95, 197-203.
15. Ihara, Y., Yoshimura, M., Miyoshi, E., Nishikawa, A., Sultan, A. S., Toyosawa, S., Ohnishi, A., Suzuki, M., Yamamura, K., Ijuhin, N., and Taniguchi, N. (1998) Ectopic expression of N-acetylglucosaminyltransferase III in transgenic hepatocytes disrupts apolipoprotein B secretion and induces aberrant cellular morphology with lipid storage. Proc. Natl. Acad. Sci. USA 95, 2526-2530.
16. Ishibashi, K., Nishikawa, A., Hayashi, N., Kasahara, A., Sato, N., Fujii, S., Kamada, T., and Taniguchi, N. (1989) N-acetylglucosaminyltransferase III in human serum, and liver and hepatoma tissues: increased activity in liver cirrhosis and hepatoma patients. Clin. Chim. Acta 185, 325-332.
17. Kang, B.-S., Kim, Y-J., Shim, J.-K., Song, E.-Y., Park, Y.-G., Lee, Y.-C., Nam, K.-S., Kim, J.-K., Lee, T.-K., Chung, T.-W., and Kim, C.-H. (1998) Identification of a new 5′noncoding exon region and promoter activity of human N-acetylglucosaminyltransferase III gene. J. Biochem. Mol. Biol. 31, 578-584.
18. Kim, C. H. (2003) A Salmonella typhimurium rfaE mutant recovers invasiveness for human epithelial cells when complemented by wild type rfaE (controlling biosynthesis of ADP-L-glycero-D-manno-heptose-containing lipopolysaccharide). Mol. Cells 15, 226-232.
19. Kim, Y-J., Kim, K.-S., Ko, J.-H., Lee, Y.-C., Chung, T.-W., Choe, I.-S., and Kim, C.-H. (1996) Sequence analysis of the 5′-flanking region of the gene encoding human N-acetylglucosaminyltransferase III. Gene 170, 281-283.
20. Kim, S. K., Koh, S. K., Song, S. U., Shin, S. H.; Choi, G. S., Kim, W. C., Lee, M. H., Seoh, J. Y., Park, S. K., and Fraser, J. K. (2002) Ex vivo Expansion and clonality of CD34+ selected cells from bone marrow and cord blood. Mol. Cells 14, 367-373.
21. Koma, M., Miyagawa, S., Honke, K., Ikeda, Y., Koyota, S., Miyoshi, S., Matsuda, H., Tsuji, S., Shirakura, R., and Taniguchi, N. (2000) Reduction of the major xenoantigen on glycosphingolipids of swine endothelial cells by various glycosyltransferases. Glycobiology 10, 745-751.
22. Koyota, S., Ikeda, Y., Miyagawa, S., Ihara, H., Koma, M., Honke, K., Shirakura, R., and Taniguchi, N. (2001) Downregulation of the α-Gal epitope expression in N-glycans of swine endothelial cells by transfection with the N-acetylglucosaminyltransferase III gene. Modulation of the biosynthesis of terminal structures by a bisecting GlcNAc. J. Biol. Chem. 276, 32867-32874.
23. Laemmli, U. K. (1950) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
24. Lambrigts, D., Sachs, D. H., and Cooper, D. K. (1998) Discordant organ xenotransplantation in primates: world experience and current status. Transplantation 66, 547-561.
25. Lee, J. W., Song, E. Y., Chung, T. W., Kim, K. S., Chung, T. H., Yeom, Y. I., and Kim, C. H. (2003) Hyperexpression of GnT-III in transgenic mice caused fatty body and obesity. Arch. Biochem. Biophys. (in press).
26. Lowry, O. H., Rosenbrough, N. H., and Farr, A. L. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
27. McCurry, K. R., Kooyman, D. L., Alvarado, C. G., Cotterell, A. H., Martin, M. J., Logan, J. S., and Platt, J. L. (1995) Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury. Nat. Med. 1, 423-427.
28. McKenzie, I. F., Li, Y. Q., Patton, K., and Sandrin, M. S. (2000) Fucosyl transferase (H) transgenic heart transplants to Gal-/-mice. Transplantation 70, 1205-1209.
29. Miyagawa, S., Shirakura, R., Iwata, K., Nakata, S., Matsumiya, G., Izutani, H., Matsuda, H., Terado, A., Matsumoto, M., Nagasawa, S., and Seya, T. (1994) Effects of transfected complement regulatory proteins, MCP, DAF, and MCP/DAE hybrid, on complement-mediated swine endothelial cell lysis. Transplantation 58, 834-840.
30. Miyagawa, S., Nakai, R., Yamada, M., Tanemura, M., Ikeda, Y., Taniguchi, N., and Shirakura, R. (1999) Regulation of natural killer cell-mediated swine endothelial cell lysis through genetic remodeling of a glycoantigen. J. Biochem. 126, 1067-1073.
31. Miyagawa, S., Murakami, H., Takahagi, Y., Nakai, R., Yamada, M., Murase, A., Koyota, S., Koma, M., Matsunami, K., Fukuda, D., Fujimura, T., Shigehisa, T., Okabe, M., Nakashima, H., Shirakura, R., and Taniguchi, N. (2001) Remodeling of the major pig xenoantigen by N-acetylglucosaminyltransferase III in transgenic pig. J. Biol. Chem. 19, 39310-39319.
32. Mogan, B., Constantini, F., and Lacy, E. (1986) Manipulating the Mouse Embryo: A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
33. Nicholson-Weller, A., Burge, J., Fearon, D. T., Weller, P. F., and Austen, K. F. (1982) Isolation of a human erythrocyte membrane glycoprotein with decay-accelerating activity for C3 convertases of the complement system. J. Immunol. 129, 184-189.
34. Nishikawa, A., Gu, J., Fujii, S., and Taniguchi, N. (1990) Determination of N-acetylglucosaminyltransferase III and V in normal and hepatoma tissues of rat. Biochim. Biophys. Acta 1035, 313-318.
35. Okada, H., Nagami, Y., Takahashi, K., Okada, N., Hideshima, T., Takizawa, H., and Kondo, J. (1989) 20 KDa homologous restriction factor of complement resembles T cell activating protein. Biochem. Biophys. Res. Commun. 162, 1553-1559.
36. Osman, N., McKenzie, I. F. C., Ostenried, K., Ioannou, Y. A., Desnick, R. J., and Sandrin, M. S. (1998) Combined transgenic expression of a-galactosidase and α1,2-fucosyltransferase leads to optimal reduction in the major xenoepitope Galα(1,3)Gal. Proc. Natl. Acad. Sci. USA 94, 14677-14682.
37. Park, C., Jin, U.-H., Lee, Y.-C., Cho, T.-J., and Kim, C.-H. (1999) Characterization of UDP-N-acetylglucosamine: β-6-D-mannoside β-1,6-N-acetylglucosaminyltransferase-V from a human hepatoma cell line Hep3B. Arch. Biochem. Biophys. 367, 281-288.
38. Rademacher, T. W., Parekh, R. B., and Dwek, R. A. (1988) Glycobiology. Ann. Rev. Biochem. 57, 785-788.
39. Rosengard, A. M., Cary, N. R., Langford, G. A., Tucker, A. W., Wallwork, J., and White, D. J. (1995) Tissue expression of human complement inhibitor, decay-accelerating factor, in transgenic pigs. A potential approach for preventing xenograft rejection. Transplantation 59, 1325-1333.
40. Sambrook, J., Fritsch, E. F., and Maniatic, T. (1989) Molecular Cloning: A Laboratory Manual, Vol. II, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
41. Sandrin, M. S., Fodor, W. L., Mouhtouris, E., Osman, N., Cohney, S., Rollins, S. A., Guilmette, E. R., Setter, E., Squinto, S. P., and McKenzie, I. F. C. (1995) Enzymatic remodelling of the carbohydrate surface of a xenogenic cell substantially reduces human antibody binding and complement-mediated cytolysis. Nat. Med. 1, 1261-1267.
42. Schachter, H. (1990) Biosynthetic controls that determine the branching and microheterogeneity of protein-bound oligosaccharides. Biochem. Cell. Biol. 64, 163-181.
43. Sepp, A., Skacel, P., Lindstedt, R., and Lechler, R. I. (1997) Expression of α1,3-galactose and other type 2 oligosaccharide structures in a porcine endothelial cell line transfected with human α1,2- fucosyltransferase cDNA. J. Biol. Chem. 272, 23104-23110.
44. Serafini-Cessi, F., Francecshi, C., and Sperti, S. (1979) Specific interaction of human Tamm-Horsfall gylcoprotein with leucoagglutinin, a lectin from Phaseolus vulgaris (red kidney bean). Biochem. J. 183, 381-388.
45. Seya, T., Turner, J. R., and Atkinson, J. P. (1986) Purification and characterization of a membrane protein (gp45-70) that is a cofactor for cleavage of C3b and C4b. J. Exp. Med. 163, 837-855.
46. Sharma, A., Okabe, J., Birch, P., McClellan, S. B., Martin, M. J., Platt, J. L., and Logan, J. S. (1996) Reduction in the level of Gal(α1,3)Gal in transgenic mice and pigs by the expression of an α(1,2)fucosyltransferase. Proc. Natl. Acad. Sci. USA 93, 7190-7195.
47. Sheng, Y., Yoshimura, M., Inoue, S., Oritani, K., Nishiura, T., Yoshida, H., Ogawa, M., Okajima, Y., Matsuzawa, Y., and Taniguchi, N. (1997) Remodeling of glycoconjugates on CD44 enhances cell adhesion to hyaluronate, tumor growth and metastasis in B16 melanoma cells expressing β1,4-N- acetylglueosaminyltransferase III. Int. J. Cancer 73, 850-858.
48. Sheweita, S. A., Abd El-Gabar, M., and Bastawy, M. (2001) Carbon tetrachloride-induced changes in the activity of phase II drug-metabolizing enzyme in the liver of male rats: role of antioxidants. Toxicology 165, 217-224.
49. Song, E.-Y., Kim, K.-A., Kim, Y.-D., Kwon, D.-H., Lee, H.-S., Kim, C.-H., Chung, T.-W., and Byun, S.-M. (2000) A simplified procedure for the purification of human N-acetylglucosaminyltyransferase-III from human hepatocellular carcinoma tissues. Biotechnol. Lett. 22, 201-204.
50. Song, E.-Y., Lee, Y.-C., Park, Y.-G., Chung, T.-W., and Kim, C.-H. (2001) Expression of bisecting N-acetylglucosaminyltransferase-III in human hepatocarcinoma tissues, fetal liver tissues, and hepatoma cell lines of Hep3B and HepG2. Cancer Investigation 19, 797-805.
51. Song, E.-Y., Chung, T.-H., Yeom, Y.-I., and Kim, C.-H. (2003a) Transgenic mice for over-expression of human N-acetylglucosamintransferase-III and method for producing of the same. Korean Patent No. 10-02-0033515.
52. Song, E.-Y., Kim, K.-S., Kim, K.-A., Kim, Y.-D., Kwon, D.-H., Byun, S.-M., Kim, H.-J., Chung, T.-W., and Kim, C.-H. (2003b) Evaluation of N-acetylgucosaminyltransferase III-like proteins in the serum of patients with chronic hepatitis and liver cirrhosis. Glycoconjugate J. (in press).
53. Southern, E. M. (1975) Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98, 503-505.
54. Tanemura, M., Miyagawa, S., Ihara, Y., Matsuda, H., Shirakura, R., and Taniguchi, N. (1997) Significant downregulation of the major swine xenoantigen by N-acetylglueosaminyltransferase III gene transfection. Biochem. Biophys. Res. Commun. 235, 359-364.
55. Tanemura, M., Miyagawa, S., Koyota, S., Koma, M., Matsuda, H., Tsuji, S., Shirakura, R., and Taniguchi, N. (1998) Reduction of the major swine xenoantigen, the α-galactosyl epitope by transfection of the α2,3-sialyltransferase gene. J. Biol. Chem. 273, 16421-16425.
56. Tanemura, M., Maruyama, S., and Galili, U. (2000) Differential expression of α-GAL epitopes (Galα1-3Galβ1-4GlcNAc-R) on pig and mouse organs. Transplantation 69, 187-190.
57. Taniguchi, N., Yoshimura, M., Miyoshi, E., Ihara, Y., Nishikawa, A., and Fujii, S. (1996) Remodeling of cell surface glycoproteins by N-acetylglucosaminyltransferase III gene transfection: modulation of metastatic potentials and down regulation of hepatitis B virus replication. Glycobiology 6, 691-694.
58. Yamashita, K., Hitoi, A., and Kobata, A. (1983) Structural determinants of Phaseolus vulgaris erythroagglutinating lectin for oligosaccharides. J. Biol. Chem. 258, 14753-14755.
59. Yau, Y. and Waer, M. (2003) Opportunities and risks of xenogeneic thymus transplantation. Transplantation 75, 263-264.
60. Yoshimura, M., Nishikawa, A., Ihara, Y., Taniguchi, S., and Taniguchi, N. (1995) Suppression of lung metastasis of B16 mouse melanoma by N-acetylglucosaminyltransferase III gene transfection. Proc. Natl. Acad. Sci. USA 92, 8754-8758.