Fucosyl transferase (H) transgenic heart transplants to Gal-/- mice

Transplantation

Volumn 70, Issue 8, 2000, Pages 1205-1209

  McKenzie, Ian F C ^a   Li, Yu Qin ^a   Patton, Katherine ^a   Sandrin, Mauro S ^a  

^a AUSTIN RESEARCH INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; FUCOSYLTRANSFERASE; GALACTOSE;

ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTHUS PHENOMENON; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; HISTOPATHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SHWARTZMAN PHENOMENON; TRANSGENIC MOUSE; XENOTRANSPLANTATION;

EID: 0034721846     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200010270-00014     Document Type: Article

References (18)

1. Galα(1,3)Gal, the major xenoantigen(s) recognised in pigs by human natural antibodies
2. Antipig IgM antibodies in human serum reacts predominantly with Gala(1,3)Gal epitopes
3. Identification of alpha-galactosyl and other carbohydrate epitopes that are bound by human anti-pig antibodies: Relevance to discordant xenografting in man
4. Identification of carbohydrate structures that bind human antiporcine antibodies: Implications for discordant xenografting in humans
5. Enzymatic remodeling of the carbohydrate surface of a xenagenic cell substantially reduces human antibody binding and complement-mediated cytolysis
6. Down regulation of Gala(1,3)Gal expression by α1,2 fucosyltransferase: Further characterization of α1,2fucosyltransferase transgenic mice
7. Switching amino terminal cytoplasmic domains of α1,2fucosyltransferase and α1,3 galactosyltransferase alters the expression of H substance and Gala(1,3)Gal
8. Reduction in the level of Gal(α1,3)Gal in transgenic mice and pigs by the expression of an α(1,2)fucosyltransferase
9. Introduction of α(1,2)-fucosyltransferase and its effect on α-Gal epitopes in transgenic pig
10. A murine model for antibody mediated hyperacute rejection due to anti-Galα(1,3)Gal antibodies in Gal o/o mice
11. Oocyte Galα1,3Gal epitopes implicated in sperm adhesion to the zona pellucida glycoprotein ZP3 are not required for fertilization in the mouse
12. Knock out of alpha1,3-galactosyltransferase or expression of alphal,2-fucosyltransferase further protects CD55- and CD59-expressing mouse hearts in an ex viva model of xenograft rejection
13. Transgenic expression of human alpha1,2-fucosyltransferase (H-transferase) prolongs mouse heart survival in an ex viva model of xenograft rejection
14. Patterns of vascular damage in the antibody-mediated rejection of skin xenografts in the mouse
15. Modulation of αGal epitope expression on porcine cells
16. The generation of transgenic pigs as potential organ donors for humans
17. High level porcine endothelial cell expression of α(1,2)-fucosyltransferase reduces human monocyte adhesion and activation
18. Human natural killer lymphocytes directly recognize evolutionarily conserved oligosaccharide ligands expressed by xenogeneic tissues