CpG Oligonucleotides Elicit Antitumor Responses in a Human Melanoma NOD/SCID Xenotransplantation Model

Journal of Investigative Dermatology

Volumn 122, Issue 2, 2004, Pages 387-391

  Krepler, Clemens ^a   Wacheck, Volker ^a,e   Strommer, Sabine ^a   Hartmann, Gunther ^b   Polterauer, Peter ^a   Wolff, Klaus ^a   Pehamberger, Hubert ^a,c   Jansen, Burkhard ^a,d  

^a UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF MUNICH   (Germany)

^c LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^e UNIVERSITY OF VIENNA   (Austria)

Author keywords

Antisense oligonucleotides; Dendritic cells; Immunostimulation; Macrophages

Indexed keywords

CPG OLIGONUCLEOTIDE; INTERLEUKIN 12; OLIGONUCLEOTIDE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL INVASION; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; HUMAN; HUMAN CELL; LANGERHANS CELL; LYMPH NODE; LYMPHATIC DRAINAGE; MACROPHAGE; MELANOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR XENOGRAFT; XENOTRANSPLANTATION;

EID: 1442299052     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-202X.2004.22202.x     Document Type: Article

References (25)

1. Ballas ZK, Rasmussen WL, Krieg AM: Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J Immunol 157:1840-1845, 1996
2. Ballas ZK, Krieg AM, Warren T, Rasmussen W, Davis HL, Waldschmidt M, Weiner GJ: Divergent therapeutic and immunologic effects of oligodeoxynucleotides with distinct CpG motifs. J Immunol 167:4878-4886, 2001
3. Ban E, Dupre L, Hermann E, et al: CpG motifs induce Langerhans cell migration in vivo. Int Immunol 12:737-745, 2000
4. Bird AP: DNA methylation and the frequency of CpG in animal DNA. Nucl Acids Res 8:1499-1504, 1980
5. Chapman PB, Einhorn LH, Meyers ML, et al: Phase III multicenter randomized trial of the Dartmouth regimen versus dacarbazine in patients with metastatic melanoma. J Clin Oncol 17:2745-2751, 1999
6. Dreiling L, Hoffman S, Robinson WA: Melanoma: Epidemiology, pathogenesis, and new modes of treatment. Adv Intern Med 41:553-604, 1996
7. Hacker H, Mischak H, Hacker G, Eser S, Prenzel N, Ullrich A, Wagner H: Cell type-specific activation of mitogen-activated protein kinases by CpG-DNA controls interleukin-12 release from antigen-presenting cells. EMBO J 18:6973-6982, 1999
8. Hartmann G, Weiner GJ, Krieg AM: CpG DNA: A potent signal for growth, activation, and maturation of human dendritic cells. Proc Natl Acad Sci USA 96:9305-9310, 1999
9. Hemmi H, Takeuchi O, Kawai T, et al: Toll-like receptor recognizes bacterial DNA. Nature 408:740-745, 2000
10. Jakob T, Walker PS, Krieg AM, Udey MC, Vogel JC: Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: A role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA. J Immunol 161:3042-3049, 1998
11. Jakob T, Walker PS, Krieg AM, von Stebut E, Udey MC, Vogel JC: Bacterial DNA and CpG-containing oligodeoxynucleotides activate cutaneous dendritic cells and induce IL-12 production: Implications for the augmentation of Th1 responses. Int Arch Allergy Immunol 118:457-461, 1999
12. Jansen B, Schlagbauer WH, Brown BD, et al: bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice. Nat Med 4:232-234, 1998
13. Jiang W, Swiggard WJ, Heufler C, Peng M, Mirza A, Steinman RM, Nussenzweig MC: The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature 375:151-155, 1995
14. Klasa RJ, Bally MB, Ng R, Goldie JH, Gascoyne RD, Wong FM: Eradication of human non-Hodgkin's lymphoma in SCID mice by BCL-2 antisense oligonucleotides combined with low-dose cyclophosphamide. Clin Cancer Res 6:2492-2500, 2000
15. Klimp AH, de Vries EG, Scherphof GL, Daemen T: A potential role of macrophage activation in the treatment of cancer. Crit Rev Oncol Hematol 44:143-161, 2002
16. Krieg AM, Yi AK, Matson S, et al: CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374:546-549, 1995
17. Krug A, Rothenfusser S, Hornung V, et al: Identification of CpG oligonucleotide sequences with high induction of IFN-α/β in plasmacytoid dendritic cells. Eur J Immunol 31:2154-2163, 2001
18. Langenkamp A, Messi M, Lanzavecchia A, Sallusto F: Kinetics of dendritic cell activation: Impact on priming of TH1, TH2 and nonpolarized T cells. Nat Immunol 1:311-316, 2000
19. Manzel L, Macfarlane DE: Lack of immune stimulation by immobilized CpG-oligodeoxynucleotide. Antisense Nucl Acid Drug Dev 9:459-464, 1999
20. Schnare M, Holt AC, Takeda K, Akira S, Medzhitov R: Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88. Curr Biol 10:1139-1142, 2000
21. Shultz LD, Schweitzer PA, Christianson SW, et al: Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J Immunol 154:180-191, 1995
22. Sparwasser T, Koch ES, Vabulas RM, Heeg K, Lipford GB, Ellwart JW, Wagner H: Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur J Immunol 28:2045-2054, 1998
23. Stadelmann WK, Rapaport DP, Soong S, Reintgen DS, Buzaid AC, Balch CM: Prognostic clinical and pathological features. In: Balch CM, Houghton AN, Sober AJ, Soong S, (eds). Cutaneous Melanoma, 3rd edn. St Louis, Mo: Quality Medical Publishing, 1998; p 11-36
24. Swiggard WJ, Mirza A, Nussenzweig MC, Steinman RM: DEC-205, a 205-kDa protein abundant on mouse dendritic cells and thymic epithelium that is detected by the monoclonal antibody NLDC-145: Purification, characterization, and N-terminal amino acid sequence. Cell Immunol 165:302-311, 1995
25. Valladeau J, Clair-Moninot V, Dezutter-Dambuyant C, et al: Identification of mouse langerin/CD207 in Langerhans cells and some dendritic cells of lymphoid tissues. J Immunol 168:782-792, 2002