A Synthetic Superoxide Dismutase/Catalase Mimetic (EUK-134) Inhibits Membrane-Damage-Induced Activation of Mitogen-Activated Protein Kinase Pathways and Reduces p53 Accumulation in Ultraviolet B-Exposed Primary Human Keratinocytes

Journal of Investigative Dermatology

Volumn 122, Issue 2, 2004, Pages 484-491

  Decraene, David ^a   Smaers, Katrien ^a   Gan, David ^b   Mammone, Tom ^b   Matsui, Mary ^b   Maes, Daniel ^b   Declercq, Lieve ^c   Garmyn, Marjan ^a,d  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b Estee Lauder Inc   (United States)

^c Estee Lauder Coordination Center   (Belgium)

^d UZ St Rafaël ^*  (Belgium)

Author keywords

Hydrogen peroxide; Manganese compounds; Oxidative stress; p53 phosphorylation; Skin

Indexed keywords

CATALASE; MANGANESE N,N' ETHYLENEBIS(3 METHOXYSALICYLIDENEAMINE); MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P53; SUPEROXIDE DISMUTASE;

AMINO TERMINAL SEQUENCE; ARTICLE; BIOACCUMULATION; BIOSENSOR; CELL DAMAGE; CELL MEMBRANE; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME REGULATION; HUMAN; HUMAN CELL; KERATINOCYTE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; RADIATION EXPOSURE; RADIATION INJURY; RADIATION RESPONSE; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE;

EID: 1442299048     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-202X.2004.22215.x     Document Type: Article

References (38)

1. Assefa Z, Garmyn M, Bouillon R, Merlevede W, Vandenheede JR, Agostinis P: Differential stimulation of ERK and JNK activities by ultraviolet B irradiation and epidermal growth factor in human keratinocytes. J Invest Dermatol 108:886-891, 1997
2. Baker K, Marcus CB, Huffman K, Kruk H, Malfroy B, Doctrow SR: Synthetic combined superoxide dlsmutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: A key role for reactive oxygen species in ischemic brain injury. J Pharmacol Exp Ther 284:215-221, 1998
3. Baudry M, Etienne S, Bruce A, Palucki M, Jacobsen E, Malfroy B: Salen-manganese complexes are superoxide dismutase-mimics. Biochem Biophys Res Commun 192:964-968, 1993
4. Beers RF, Sober AJ: A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem 195:133-144, 1952
5. Brown DB, Peritz AE, Uitto J, Gasparro FP: Ultraviolet-filtering properties of commonly used tissue cell culture plasticware. Photodermatol Photoimmunol Photomed 17:126-129, 2001
6. Bulavin DV, Saito S, Hollander MC, Sakaguchi K, Anderson CW, Appella E, Fornace AJ Jr: Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J 18:6845-6854, 1999
7. Buschmann T, Potapova O, Bar-Shira A, et al: Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress. Mol Cell Biol 21:2743-2754, 2001
8. Clydesdale GJ, Dandie GW, Muller HK: Ultraviolet light induced injury: Immunological and inflammatory effects. Immunol Cell Biol 79:547-568, 2001
9. Decraene D, Agostinis P, Pupe A, de Haes P, Garmyn M: Acute response of human skin to solar radiation: Regulation and function of the p53 protein. J Photochem Photobiol B 63:78-83, 2001
10. de Gruijl FR, van Kranen HJ, Mullenders LH: UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer. J Photochem Photobiol B 63:19-27, 2001
11. Doctrow SR, Huffman K, Marcus CB, et al: Salen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: Structure-activity relationship studies. J Med Chem 45:4549-4558, 2002
12. Doctrow SR, Huffman K, Marcus CB, Musleh W, Bruce A, Baudry M, Malfroy B: Salen-manganese complexes: Combined superoxide dismutase/catalase mimics with broad pharmacological efficacy. Adv Pharmacol 38:247-269, 1997
13. Fautz R, Husein B, Hechenberger C: Application of the neutral red assay (NR assay) to monolayer cultures of primary hepatocytes: Rapid colorimetric viability determination for the unscheduled DNA synthesis test (UDS). Mutat Res 253:173-179, 1991
14. Giaccia AJ, Kastan MB: The complexity of p53 modulation: Emerging patterns from divergent signals. Genes Dev 12:2973-2983, 1998
15. Gilchrest BA: In vitro assessment of keratinocyte aging. J Invest Dermatol 81:184s-189s, 1983
16. Gilchrest BA, Park HY, Eller MS, Yaar M: Mechanisms of ultraviolet light-induced pigmentation. Photochem Photobiol 63:1-10, 1996
17. Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Derijard B, Davis RJ: Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J 15:2760-2770, 1996
18. Kaltenbach JP, Kaltenbach MH, Lyons WB: Nigrosin as a dye for differentiating live and dead ascites cells. Exp Cell Res 15:112-117, 1958
19. Kimura H, Nakano M: Highly sensitive and reliable chemiluminescence method for the assay of superoxide dismutase in human erythrocytes. FEBS Lett 239:347-350, 1988
20. Klein D, Kern RM, Sokol RZ: A method for quantification and correction of proteins after transfer to immobilization membranes. Biochem Mol Biol Int 36:59-66, 1995
21. Kulms D, Zeise E, Poppelmann B, Schwarz T: DNA damage, death receptor activation and reactive oxygen species contribute to ultraviolet radiation-induced apoptosis in an essential and independent way. Oncogene 21:5844-5851, 2002
22. Liegeois C, Lermusieau G, Collin S: Measuring antioxidant efficiency of wort, malt, and hops against the 2,2-azobis(2-amidinopropane) dihydrochloride-induced oxidation of an aqueous dispersion of linoleic acid. J Agric Food Chem 48:1129-1134, 2000
23. Liu R, Liu IY, Bi X, Thompson RF, Doctrow SR, Malfroy B, Baudry M: Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics. Proc Natl Acad Sci USA 100:8526-8531, 2003
24. Ma W, Wlaschek M, Tantcheva-Poor I, et al: Chronological ageing and photoageing of the fibroblasts and the dermal connective tissue. Clin Exp Dermatol 26:592-599, 2001
25. Malfroy B, Doctrow SR, Orr PL, Tocco G, Fedoseyeva EV, Benichou G: Prevention and suppression of autoimmune encephalomyelitis by EUK-8, a synthetic catalytic scavenger of oxygen-reactive metabolites. Cell Immunol 177:62-68, 1997
26. Melov S, Doctrow SR, Schneider JA, et al: Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics. J Neurosci 21:8348-8353, 2001
27. Melov S, Ravenscroft J, Malik S, et al: Extension of life-span with superoxide dismutase/catalase mimetics. Science 289:1567-1569, 2000
28. Oda K, Arakawa H, Tanaka T, et al: p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell 102:849-862, 2000
29. 2 is required for UVB-induced EGF receptor and downstream signaling pathway activation. Free Radic Biol Med 27:1197-1202, 1999a
30. Peus D, Vasa RA, Beyerle A, Meves A, Krautmacher C, Pittelkow MR: UVB activates ERK1/2 and p38 signaling pathways via reactive oxygen species in cultured keratinocytes. J Invest Dermatol 112:751-756, 1999b
31. Rong Y, Doctrow SR, Tocco G, Baudry M: EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology. Proc Natl Acad Sci USA 96:9897-9902, 1999
32. Rosette C, Karin M: Ultraviolet light and osmotic stress: Activation of the JNK cascade through multiple growth factor and cytokine receptors. Science 274:1194-1197, 1996
33. Sander CS, Chang H, Salzmann S, Muller CS, Ekanayake-Mudiyanselage S, Elsner P, Thiele JJ: Photoaging is associated with protein oxidation in human skin in vivo. J Invest Dermatol 118:618-625, 2002
34. Scharffetter-Kochanek K, Wlaschek M, Brenneisen P, Schauen M, Blaudschun R, Wenk J: UV-induced reactive oxygen species in photocarcinogenesis and photoaging. Biol Chem 378:1247-1257, 1997
35. Sharpless NE, DePinho RA: p53: Good cop/bad cop. Cell 110:9-12, 2002
36. She QB, Chen N, Dong Z: ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation. J Biol Chem 275:20444-20449, 2000
37. Taylor CR, Sober AJ: Sun exposure and skin disease. Annu Rev Med 47:181-191, 1996
38. Young PR, McLaughlin MM, Kumar S, et al: Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site. J Biol Chem 272:12116-12121, 1997