Innate immune responses to adenoviral vector-mediated acute pancreatitis

Pancreas

Volumn 30, Issue 2, 2005, Pages 122-129

  Shifrin, Alexander L ^a   Chirmule, Narendra ^b   Gao, Guang Ping ^a   Wilson, James M ^a   Raper, Steven E ^a,c,d  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Adenoviral vector; Interleukin 10; Interleukin 12; Interleukin 6; Macrophages; Natural killer cells; Natural killer T lymphocytes; Rodent

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; CARBOCYANINE; CYTOKINE; GREEN FLUORESCENT PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12;

ACUTE PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL INFILTRATION; CELL MEMBRANE; CELL MIGRATION; CELL NUCLEUS; CONTROLLED STUDY; COVALENT BOND; FEMALE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; INNATE IMMUNITY; INTERNALIZATION; MACROPHAGE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS CAPSID; VIRUS PARTICLE; VIRUS RECOMBINANT;

ACUTE DISEASE; ADENOVIRIDAE; ADENOVIRIDAE INFECTIONS; ANIMALS; BETA-GALACTOSIDASE; CAPSID; FEMALE; GENES, REPORTER; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-6; KILLER CELLS, NATURAL; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; PANCREATITIS; SPLEEN;

EID: 14244265803     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mpa.0000151578.99413.88     Document Type: Article

References (42)

1. Torre J, Martin J, Garcia C, et al. Varicella infection as a cause of acute pancreatitis in an immunocompetent child. Pediatr Infect Dis J. 2000; 19:1218-1219.
2. Ikura Y, Matsuo T, Ogami M, et al. Cytomegalovirus associated pancreatitis in a patient with systemic lupus erythematosus. J Rheumatol. 2000;27:2715-2717.
3. Zaragoza C, Ocampo C, Saura M, et al. Inducible nitric oxide synthase protection against Coxsackievirus pancreatitis. J Immunol. 1999;163: 5497-5504.
4. Washington K, Gossage D, Gottfried M. Pathology of the pancreas in severe combined immunodeficiency and DiGeorge syndrome: acute graft-versus-host disease and unusual viral infections. Hum Pathol. 1994; 25:908-914.
5. Lerner A, Branski D, Lebenthal E. Pancreatic diseases in children. Pediatr Clin North Am. 1996;43:125-156.
6. Carter B, Karpen S, Quiros-Tejeira R, et al. Intravenous cidofovir therapy for disseminated adenovirus in a pediatric liver transplant recipient. Transplantation. 2002;74:1050-1052.
7. Keaveny A, Karasik M. Hepatobiliary and pancreatic infections in AIDS: part one. AIDS Patient Care STDS. 1998;12:347-357.
8. Mulvihill S, Warren R, Venook A, et al. Safety and feasibility of injection with an E1B-55 kDa gene-deleted, replication-selective adenovirus (ONYX-015) into primary carcinomas of the pancreas: a phase I trial. Gene Ther. 2001;8:308-315.
9. Shifrin A, Auricchio A, Yu Q-C, et al. Adenoviral vector-mediated insulin gene transfer in the mouse pancreas corrects streptozotocin-induced hyperglycemia. Gene Ther. 2001;8:1480-1489.
10. Raper SE, DeMatteo RP. Adenovirus-mediated in vivo gene transfer and expression in normal rat pancreas. Pancreas. 1996;12:401-410.
11. McClane SJ, Hamilton TE, DeMatteo RP, et al. Effect of adenoviral early genes and the host immune system on in vivo pancreatic gene transfer in the mouse. Pancreas. 1997;15:236-245.
12. McClane SJ, Hamilton TE, Burke CV, et al. Functional consequences of adenovirus-mediated murine pancreatic gene transfer. Hum Gene Ther. 1997;8:739-746.
13. McClane SJ, Chirmule N, Burke CV, et al. Characterization of the immune response after local delivery of recombinant adenovirus in murine pancreas and successful strategies for readministration. Hum Gene Ther. 1997;8:2207-2216.
14. Routes J, Cook J. Resistance of human cells to the adenovirus E3 effect on class I MHC antigen expression. Implications for antiviral immunity. J Immunol. 1990;144:2763-2770.
15. Duerksen-Hughes P, Wold W, Gooding L. Adenovirus E1A renders infected cells sensitive to cytolysis by tumor necrosis factor. J Immunol. 1989;143:4193-4200.
16. Ackrill A, Foster G, Laxton C, et al. Inhibition of the cellular response to interferons by products of the adenovirus type 5 E1A oncogene. Nucleic Acids Res. 1991;19:4387-4393.
17. Ilan Y, Droguett G, Choudhury N, et al. Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression. Proc Natl Acad Sci USA. 1997;94:2587-2592.
18. Coutelier J, VanBroeck J, Wolf S. Interleukin-12 gene expression after viral infection in the mouse. J Virol. 1995;69:1955-1958.
19. Lieber A, He C, Meuse L, et al. The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors. J Virol. 1997;71:8798-8807.
20. Andrews K, Ribas A, Butterfield L, et al. Adenovirus-interleukin-12- mediated tumor regression in a murine hepatocellular model is not dependent on CD1-restricted natural killer T cells. Cancer Res. 2000; 60:6457-6464.
21. Aderem A, Underhill D. Mechanism of phagocytosis in macrophages. Annu Rev Immunol. 1999;17:593-623.
22. Day D, Zachariades N, Gooding L. Cytolysis of adenovirus-infected murine fibroblasts by IFN-gamma-primed macrophages is TNF- and contact-dependent. Cell Immunol. 1994;157:223-228.
23. Stein C, Pemberton J, vanRooijen N, et al. Effects of macrophage depletion and anti-CD-40 ligand on transgene expression and re-dosing with recombinant adenovirus. Gene Ther. 1998;5:431-439.
24. Jooss K, Ertl HC, Wilson JM. Cytotoxic T-lymphocyte target proteins and their major histocompatibility complex class I restriction in response to adenovirus vectors delivered to mouse liver. J Virol. 1998;72:2945-2954.
25. Engelhardt JF, Ye X, Doranz B, et al. Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc Natl Acad Sci USA. 1994;91:6196-6200.
26. Leopold P, Ferris B, Grinberg I, et al. Fluorescent virions: dynamic tracking of the pathway of adenoviral gene transfer vectors in living cells. Hum Gene Ther. 1998;9:367-378.
27. Hume D, Perry V, Gordon S. The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F4/80: macrophages associated with epithelia. Anat Rec. 1984;210:503-512.
28. Austyn J, Gordon S. F4/80, a monoclonal antibody directed specifically against the mouse macrophage. Eur J Immunol. 1981;11:805-815.
29. Lee S, Starkey P, Gordon S. Quantitative analysis of total macrophage content in adult mouse tissues. Immunochemical studies with monoclonal antibody F4/80. J Exp Med. 1985;161:475-489.
30. Gordon S, Lawson L, Rabinowitz S, et al. Antigen markers of macrophage differentiation in murine tissues. Current Topics in Microbiology and Immunology. Berlin, New York: Springer-Verlag; 1992:181.
31. Kusske A, Rongion A, Ashle S, et al. IL-10 prevents death in lethal necrotizing pancreatitis in mice. Surgery. 1996;120:284-289.
32. Denham W, Denham D, Yang J, et al. Transient human gene therapy: a novel cytokine regulatory strategy for experimental pancreatitis. Ann Surg. 1998;227:812-820.
33. Hahm K, Im Y, Lee C, et al. Loss of TGF-beta signaling contributes to autoimmune pancreatitis. J Clin Invest. 2000;105:1057-1065.
34. van Laethem L, Eskinazi R, Louis H, et al. Multisystemic production of IL-10 limits the severity of acute pancreatitis in mice. Gut. 1998;43:408-413.
35. Parenti D, Steinberg W, Kang P. Infectious causes of acute pancreatitis. Pancreas. 1996;13:356-371.
36. Niemann T, Trigg M, Winick N, et al. Disseminated adenoviral infection presenting as acute pancreatitis. Hum Pathol. 1993;24:1145-1148.
37. Ploegh H. Viral strategies of immune evasion. Science. 1998;280:248-253.
38. Gooding L, Wold W. Molecular mechanism by which adenovirus counteract antiviral immune defenses. Clin Rev Immunol. 1990;1:53-71.
39. Mahr J, Gooding L. Immune evasion by adenovirus. Immunol Rev. 1999; 168:121-130.
40. Carr J, Hocking H, Li P, et al. Rapid and efficient cell-to-cell transmission of human immunodeficiency virus infection monocyte-derived macrophages to peripheral blood lymphocytes. Virology. 1999;265:319-329.
41. Zhuravskaya T, Maciejewski J, Bruening E, et al. Spread of human cytomegalovirus (HCMV) after infection of human hematopoietic progenitor cells: model of HCMV latency. Blood. 1997;90:2482-2491.
42. Biron C, Nguyen K, Pien G, et al. Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu Rev Immunol. 1999; 17:189-220.