Iron availability of a fortified processed wheat cereal: A comparison of fourteen iron forms using an in vitro digestion/human colonic adenocarcinoma (CaCo-2) cell model

British Journal of Nutrition

Volumn 93, Issue 1, 2005, Pages 65-71

  Wortley, Gary ^a   Leusner, Steven ^b   Good, Carolyn ^c   Gugger, Eric ^c   Glahn, Raymond ^d  

^a INSTITUTE OF FOOD RESEARCH   (United Kingdom)

^b Ottens Flavors   (United States)

^c GENERAL MILLS INC   (United States)

^d AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

CaCo 2; In vitro digestion; Iron availability; Iron fortification; Wheat cereals

Indexed keywords

ASCORBIC ACID; CARBONYL IRON; EDETIC ACID; FATTY ACID; FERRIC PHOSPHATE; FERRITIN; FERROUS FUMARATE; FERROUS ION; FERROUS SULFATE; GLYCINE; IRON DERIVATIVE; PHOSPHATIDYLCHOLINE; POLYSACCHARIDE; PYROPHOSPHORIC ACID DERIVATIVE; VEGETABLE PROTEIN;

ARTICLE; CELL STRAIN CACO 2; CEREAL; COFFEE; CONTROLLED STUDY; DIGESTION; FOOD; HUMAN; HUMAN CELL; IN VITRO STUDY; MILK; NUTRIENT AVAILABILITY; WHEAT; BIOLOGICAL MODEL; BIOSYNTHESIS; CHEMISTRY; COMPARATIVE STUDY; DIET SUPPLEMENTATION; FOOD HANDLING; IRON INTAKE; METHODOLOGY; NUTRITIONAL VALUE;

TRITICUM AESTIVUM;

CACO-2 CELLS; CEREALS; DIGESTION; FERRITINS; FOOD HANDLING; FOOD, FORTIFIED; HUMANS; IRON, DIETARY; MODELS, BIOLOGICAL; NUTRITIVE VALUE; TRITICUM;

EID: 14144252947     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1079/BJN20041294     Document Type: Article

References (20)

1. Alvarez-Hernandez X, Nichols G & Glass J (1991) Caco-2 cell line: a system for studying intestinal iron transport across epithelial cell monolayers. Biochem Biophys Acta 1070, 205-208.
2. Fairweather-Tait SJ, Wortley GM, Teucher B & Dainty J (2000) Iron absorption from a breakfast cereal: effects of EDTA compounds and ascorbic acid. Int J Vitam Nutr Res 70, 117-122.
3. Gangloff MB, Lai C, Van Campen DR, Miller DD, Norvell WA & Glahn RP (1996) Ferrous iron uptake but not transfer is down-regulated in Caco-2 cells grown in high iron serum-free medium. J Nutr 126, 3118-3127.
4. Glahn RP, Lee OA, Yeung A, Goldman MI & Miller DD (1998) Caco-2 cell ferritin formation predicts nonradiolabeled food iron availability in an in vitro digestion/Caco-2 cell culture model. J Nutr 128, 1555-1561.
5. Glahn R, Lee OA & Miller D (1999) In vitro digestion/Caco-2 cell culture model to determine optimal ascorbic acid to Fe ratio in rice cereal. J Food Sci 64, 925-928.
6. Glahn RP, Rassier M, Goldman MI, Lee OA & Cha J (2000) A comparison of iron availability from commercial iron preparations using an in vitro digestion/Caco-2 cell culture model. J Nutr Biochem 11, 62-68.
7. Glahn RP, Cheng Z, Welch RM & Gregorio GB (2002) Comparison of iron bioavailability from 15 rice genotypes: studies using an in vitro digestion/Caco-2 cell culture model. J Agric Food Chem 50, 3586-3591.
8. Han O, Failla ML, Hill AD, Morris ER & Smith JC Jr (1994) Inositol phosphates inhibit uptake and transport of iron and zinc by a human intestinal cell line. J Nutr 124, 580-587.
9. Harvey LJ, Armah CN, Dainty JR, Foxall RJ, Lewis DJ, Langford NJ & Fairweather-Tait SSJ (2004) The impact of menstrual blood loss on risk of iron deficiency in women of childbearing age consuming omnivorous and vegetarian diets in the UK. Am J Clin Nutr (In the Press).
10. Hoglund S & Reizenstein P (1969) Studies in iron absorption. V. Effect of gastrointestinal factors on iron absorption. Blood 34, 486-504.
11. Huebers HA, Brittenham GM, Csiba E & Finch CA (1986) Absorption of carbonyl iron. J Lab Clin Med 108, 473-478.
12. Hurrell RF (2002) Fortification: overcoming technical and practical barriers. J Nutr 132, 806S-812S.
13. Hurrell RF, Lynch SR, Trinidad TP, Dassenko SA & Cook JD (1989) Iron absorption in humans as influenced by bovine milk proteins. Am J Clin Nutr 49, 546-552.
14. Lynch S, Bothwell T, Hurrel R & MacPhail A (1993) Iron EDTA for Food Fortification. Report of the International Nutritional Anemia Consultative Group (INACG). Washington, DC: ILSI Human Nutrition Institute.
15. MacPhail AP & Bothwell TH (1992) The prevalence and causes of - nutritional iron deficiency anemia. In Nutritional Anemias, pp. 1-12 [SJ Fomon and S Zlotkin, editors]. Nestle Nutrition Workshop Series. New York: Raven Press 30.
16. MacPhail AP, Patel RC, Bothwell TH & Lamparelli RD (1994) EDTA and the absorption of iron from food. Am J Clin Nutr 59, 644-648.
17. Miller DD & Berner LA (1989) Is solubility in vitro a reliable predictor of iron bioavailability? Biol Trace Elem Res 19, 11-24.
18. Motulsky H (1995) Comparing three or more means. In Intuitive Biostatistics, pp. 255-262 [H Motulsky, editor]. New York: Oxford University Press.
19. Olivares M, Pizarro F, Pineda O, Name JJ, Hertrampf E & Walter T (1997) Milk inhibits and ascorbic acid favors ferrous bis-glycine chelate bioavailability in humans. J Nutr 127, 1407-1411.
20. Yun S, Habicht J-P, Miller DD & Glahn RP (2004) An in vitro digestion/Caco-2 cell culture system accurately predicts the effects of ascorbic acid and polyphenolic compounds on iron bioavailability in humans. J Nutr (In the Press).