Milk inhibits and ascorbic acid favors ferrous bis-glycine chelate bioavailability in humans

Journal of Nutrition

Volumn 127, Issue 7, 1997, Pages 1407-1411

  Olivares, Manuel ^a   Pizarro, Fernando ^a   Pineda, Oscar ^b   Name, José J ^b   Hertrampf, Eva ^a   Walter, Tomás ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b Lat Amer Ctr Nutr Metab Studs   (Guatemala)

Author keywords

Ascorbic acid; Humans; Iron absorption; Iron bis glycine chelate; Milk

Indexed keywords

ASCORBIC ACID; CHELATE; IRON;

ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DIET SUPPLEMENTATION; HUMAN; INTESTINE ABSORPTION; IRON ABSORPTION; IRON CHELATION; IRON STORAGE; MILK;

EID: 0030740683     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/127.7.1407     Document Type: Article

References (29)

1. Albion Laboratories, Inc. (1995) Ferrochel Technical Monograph, pp. 1-44. Albion Laboratories, Inc., Clearfield, UT.
2. American Academy of Pediatrics, Committee on Nutrition (1989) Iron fortified infant formulas. Pediatrics 84: 1114-1115.
3. Ashmead, H. D., Graff, D. J. & Ashmead, H. H. (1985) Intestinal Absorption of Metal Ions and Chelates, pp. 1-251. Charles C. Thomas Publisher, Springfield, IL.
4. Bothwell, T. H. (1983) Iron absorption. Annu. Rev. Med. 34: 55-68.
5. Colton, T. (1974) Statistics in Medicine, pp. 1-372. Little, Brown and Company, Boston, MA.
6. Cook, J. D. & Bothwell, T. H. (1984) Availability of iron from infant foods. In: Iron Nutrition in Infancy and Childhood (Stekel, A., ed.), pp. 119-145. Nestlé/ Raven Press, Vevey/New York.
7. Cook, J. D., Layrisse, M. & Finch, C. A. (1969) The measurement of iron absorption. Blood 33: 421-429.
8. DeMayer, E. & Adiels-Tegman, M. (1985) The prevalence of anemia in the world. World Health Statist. Q. 38: 302-316.
9. Eakins, J. D. & Brown, D. A. (1966) An improved method for the simultaneous determination of iron-55 and iron-59 in blood by liquid scintillation counting. Int. J. Appl. Radioact. Isotopes 17: 191-197.
10. FAO/WHO (1988) Iron. In: Requirements of Vitamin A, Iron, Folate, and Vitamin B12 (A Report of Joint FAO/WHO Expert Consultation), FAO Food and Nutrition Series no. 23, pp. 33-50. FAO, Rome, Italy.
11. Fujita, T., Tadashi, S., Uchiyama, M., Hoshida, H., Kawabe K., Yashiro J. & Wakabayashi T. (1982) Binding of iron ions with soybean protein. Hyg. Chem. 28: 106-110.
12. Galdi, M., Bassi, A., Barrio Rendo, M. E. & Valencia, M. E. (1988) Ferric glycinate iron bioavailability determined by hemoglobin regeneration method. Nutr. Rep. Int. 38: 729-735.
13. Galdi, M., Carbone, N. & Valencia, M. E. (1989a) Comparison of ferric glycinate to ferrous sulfate in model infant formulas: kinetics of vitamin losses. J. Food Sci. 54: 1530-1539.
14. Galdi, M., Carbone, N. & Valencia, M. E. (1989b) Comparison of ferric glycinate to ferrous sulfate in model infant formulas: kinetics of tba, lysine and methionine changes. J. Food Sci. 54: 1230-1233.
15. Hallberg, L., Brune Erlandsson, M., Sandberg, A.-S. & Rossander-Hultén, L. (1991) Calcium: effect of different amounts on nonheme- and heme-iron absorption in humans. Am. J. Clin. Nutr. 53: 112-119.
16. 59Fe absorption from supplemented cow milk in infants with normal and depleted iron stores. Z. Kinderheilkd. 120: 251-258.
17. Hurrell, R. F. (1984) Bioavailability of different iron compounds used to fortify formulas and cereals: technological problems. In: Iron Nutrition in Infancy and Childhood (Stekel, A., ed.), pp. 147-178. Nestlé/Raven Press, Vevey/New York.
18. Hurrell, R. F., Lynch, S. R., Trinidad, T. P., Dassenko, S. A. & Cook, J. D. (1989) Iron absorption in humans as influenced by bovine milk proteins. Am. J. Clin. Nutr. 49: 546-552.
19. International Anemia Consultative Group (INACG) (1977) Guidelines for the eradication of iron deficiency anemia: a report of the International Anemia Consultative Group, pp. 1 -29. The Nutrition Foundation, Washington, DC.
20. International Anemia Consultative Group (INACG) (1985) Measurement of iron status: a report of the International Anemia Consultative Group, pp. 1-49. The Nutrition Foundation, Washington, DC.
21. Langini, S., Carbone, N., Galdi, M., Barrio Rendo, M. E., Portela, M. L., Caro, R. & Valencia, M. E. (1988) Ferric glycinate iron bioavailability for rats. As determined by extrinsic radioisotopic labeling of infant formulas. Nutr. Rep. Int. 38:591-598.
22. Nakamoto, K. (1978) Infrared and Raman Spectra of Inorganic and Coordination Compounds, pp. 235-238. John Wiley, New York, NY.
23. Nakamoto, K., Morimoto, Y. & Martel, A. E. (1961) Infrared spectra of aqueous solutions. I. Metal chelate compounds of amino acids. J. Am. Chem. Soc. 83: 1272-1276.
24. Name, J. J. (1995) Food fortification with amino acid chelate minerals. In: Proceedings of International Conference on Human Nutrition. Marriott Hotel, Salt Lake City, Utah. January 21-22.
25. National Research Council (1989) Recommended Dietary Allowances, 10th ed., pp. 195-205. National Academy Press, Washington, DC.
26. Peters, T., Jr., Apt, L. & Ross, J. F. (1971) Effect of phosphates upon iron absorption studied in normal human subjects and in an experimental model using dialysis. Gastroenterology 61: 315-322.
27. Pineda, O., Ashmead, H. D., Perez, J. M. & Lemus, C. P. (1994) Effectiveness of iron amino acid chelate on the treatment of iron deficiency anemia in adolescents. J. Appl. Nutr. 46: 2-11.
28. Queiroz, S. S. & Torres, M. A. (1995) Anemia carencial ferropriva: aspectos fisiopatológicos e experiência com a utilizãçao do leite fortificado com ferro. Pediatria Moderna 32: 441-455.
29. Stekel, A., Olivares, M., Pizarro, F., Chadud, P., Lopez, I. & Amar, M. (1986) Absorption of fortification iron from milk formulas in infants. Am. J. Clin. Nutr. 43:917-922.