Hypothesized deficiency of guanine-based purines may contribute to abnormalities of neurodevelopment, neuromodulation, and neurotransmission in Lesch-Nyhan syndrome

Clinical Neuropharmacology

Volumn 28, Issue 1, 2005, Pages 28-37

  Deutsch, Stephen L ^a,b   Long, Katrice D ^a   Rosse, Richard B ^a,b   Mastropaolo, John ^a,b   Eller, Judy ^a  

^a DEPARTMENT OF VETERANS AFFAIRS   (United States)

^b GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

GABA; Glutamate; Guanosine; Hypoxanthine; Hypoxanthine phosphoribosyltransferase; Lesch Nyhan syndrome

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; AMINO ACID RECEPTOR BLOCKING AGENT; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; GLUTAMATE RECEPTOR; GLUTAMIC ACID; GUANOSINE; GUANOSINE PHOSPHATE; GUANOSINE TRIPHOSPHATE; HYPOXANTHINE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; INOSINE PHOSPHATE; NEUROTRANSMITTER; NUCLEOTIDE;

AUTOMUTILATION; BRAIN DEVELOPMENT; CENTRAL NERVOUS SYSTEM; DOPAMINERGIC SYSTEM; DRUG EFFECT; ENZYME DEFICIENCY; EXCITOTOXICITY; GENE EXPRESSION; GENE REPLICATION; HUMAN; LESCH NYHAN SYNDROME; NERVE CELL DIFFERENTIATION; NEUROMODULATION; NEUROTRANSMISSION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PURINE METABOLISM; PURINE SYNTHESIS; RECESSIVE INHERITANCE; REVIEW; SEX LINKAGE; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION;

ANIMALS; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LESCH-NYHAN SYNDROME; SYNAPTIC TRANSMISSION;

EID: 13944284590     PISSN: 03625664     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.wnf.0000152043.36198.25     Document Type: Review

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