Down syndrome

Chromosomal Instability and Aging: Basic Science and Clinical Implications

Volumn , Issue , 2003, Pages 441-464

  Colvin, Leslie ^a   Van Allen, Margot I ^a   Jurenka, Stania B ^b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b Willow Clinic   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 13944278700     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (80)

1. GM Martin. Genetic syndromes in man with potential relevance to the pathobiology of aging. Birth Defects Original Article Series 14:5-39, 1978.
2. MI Van Allen, SB Jurenka, J Fung. Health care concerns and guidelines for adults with Down syndrome. Am J Med Genet 89:100-110, 1999.
3. CE Stafstrom, OF Patxot, HE Gilmore, KE Wisniewski. Seizures in children with Down syndrome: etiology, characteristics and outcome. Dev Med Child Neurol 33:191-200, 1991.
4. F Lai, RS Williams. A prospective study of Alzheimer disease in Down syndrome. Arch Neurol 46:849-853, 1989.
5. N Schupf, D Kapell, B Nightengale, A Rodriguez, B Tycko, R Mayeux. Earlier onset of Alzheimer’s disease in men with Down syndrome. Neurology 50:991-995, 1998.
6. EE Visser, AP Aldenkamp, AC van Huffelen, M Kuilman, J Overweg, J van Wijk. Prospective study of the prevalence of Alzheimer type dementia in institutionalised individuals with Down syndrome. Am J Mental Retard 101:400-412, 1997.
7. GD Pearlson, SN Breiter, EH Aylward, AC Warren, M Grygorcewicz, S Frangou, PE Barta, MB Pulsifer. MRI brain changes in subjects with Down syndrome with and without dementia. Dev Med Child Neurol 40:326-334, 1998.
8. EH Aylward, Q Li, NA Honeycutt, AC Warren, MB Pulsifer, PE Barta, MD Chan, PD Smith, M Jerram, GD Pearson. MRI volumes of the hippocampus and amygdala in adults with Down’s syndrome with and without dementia. Am J Psychiatry 156:564-568, 1999.
9. VP Prasher, PC Barber, R West, P Glenholmes. The role of magnetic resonance imaging in the diagnosis of Alzheimer disease in adults with Down syndrome. Arch Neurol 53:1310-1313, 1996.
10. C Caltagirone, U Nocenti, S Vicari. Cognitive functions in adult Down syndrome. J Neurosci 54:221-230, 1990.
11. JV Haxby. Neuropsychological evaluation of adults with Down syndrome: patterns of selective impairment in non demented old adults. J Ment Defic Res 33:193-210, 1989.
12. JP Das, B Divis, J Alexander, RK Parrila, JA Naglieri. Cognitive decline due to aging among persons with Down syndrome. Res Dev Disabil 16:461-478, 1995.
13. SA Cooper, RA Collacot. Clinical features and diagnostic criteria of depression in Down syndrome. Br J Psychiatry 165:399-403, 1994.
14. VP Prasher, W Hall. Short term prognosis of depression in adults with Down’s syndrome: association with thyroid status and effects on adaptive behaviour. J Intellect Dis Res 40:32-38, 1996.
15. BA Myers, SM Pueschel. Psychiatric disorders in persons with Down syndrome. J Nerv Ment Dis 179:609-613, 1991.
16. VP Prasher, MC Chung. Cause of age-related decline in adaptive behavior of adults with Down syndrome: differential diagnoses of dementia. Am J Ment Retard 101:175-183, 1996.
17. P Witts, S Elders. The ‘Severe Impairment Battery’: assessing cognitive ability in adults with Down syndrome. Br J Clin Psychiatry 37(Pt 2):213-216, 1998.
18. A Gedye. Neuroleptic-induced dementia documented in four adults with mental retardation. Ment Retard 36:182-186, 1998.
19. A Hestnes, T Sand, K Fostad. Ocular findings in Down syndrome. J Ment Defic Res 35:194-203, 1991.
20. HM Evenhuis. Frequently occurring but little recognized disorders in Down syndrome. Ned Tijdschr Vor Geneeskde 135:1581-1584, 1991.
21. SM Pueschel. Clinical aspects of Down syndrome from infancy to adulthood. Am J Med Genet 7(suppl):52-56, 1990.
22. JM Frantz, MS Insler, M Hgenah, MB McDonald, HE Kaufman. Penetrating keratoplasty for keratoconus in Down syndrome. Am J Ophthalmol 109:143-147, 1990.
23. TJ Balkany, MP Downs, BW Jafek. Hearing loss in Down’s syndrome: a treatable handicap more common than generally recognised. Clin Pediatr 18:116-118, 1979.
24. TRJ Tubman, MD Shields, BG Craig. Congenital heart disease in Down’s syndrome: two year prospective early screening study. BMJ 302:1425-1427, 1991.
25. T Hamada, F Gejyo, Y Koshino, T Murata, M Omori, M Nishio, K Msawa, K Isaki. Echocardiographic evaluation of cardiac valvular abnormalities in adults with Down syndrome. Tohuku J Exp Med 185:31-35, 1998.
26. MD Reller, CD Morris. Is Down syndrome a risk factor for poor outcome after repair of congenital heart defects? J Pediatr 132:738-741, 1998.
27. K Suzuki, S Yamaki, S Mimori, Y Murakami, K Mori, Y Takahashi, T Kukuchi. Pulmonary vascular disease iin Down syndrome with complete atrioventricular septal defect. Am J Cardiol 86:434-437, 2000.
28. 25c. ME Thase. Longevity and mortality in Down’s syndrome. J Ment Defic Res 26: 177-192, 1982.
29. SB Sulkes. An anticipatory checklist in primary care of disabled persons. Dev Med Child Neurol 53(suppl):28/5:55, 1986.
30. AJ Bell, MS Bhate. Prevalence of overweight and obesity in Down syndrome and other mentally handicapped adults living in the community. J Intellect Disabil Res 36:359-364, 1992.
31. MB Schapiro, SI Papoport. Basal metabolic rate in healthy Down syndrome adults. J Ment Defic Res 33:211-219, 1989.
32. JL Tolmie. Down syndrome and other autosomal trisomies. In: Rimoin DL, Connor JM, Pyeritz RE, eds. Emery and Rimoin’s Principles and Practice of Medical Genetics. 3rd ed. New York: Churchill Livingstone, 1996, pp 925-971.
33. SK Gupta, VS Venkataseshan, J Churg. Mesangiocapillary glomerulonephritis in Down syndrome. Am J Nephrol 11:112-117, 1991.
34. A Lo, HG Brown, BA Fivush, AM Neu, LC Racusen. Renal disease in Down syndrome: autopsy study with emphasis on glomerular lesions. Am J Kidney Dis 31:329-353, 1998.
35. JE Dacre, ED Huskisson. Arthritis in Down syndrome. Ann Rheum Dis 47:254-255, 1988.
36. PM Olive, TS Whitecloud, JT Bennet. Lower cervical spondylosis and myelopathy in adults with Down syndrome. Spine 13:781-784, 1988.
37. A Tangerud, A Hestness, T Sand, S Sunndasfoll. Degenerative changes in the cervical spine in Down syndrome. J Ment Defic Res 34:179-185, 1990.
38. JE Christensen, PJ Peter, VK Nielsen, J Mai. Prevalence of carpal tunnel syndrome among individuals with Down syndrome. Am J Ment Retard 102:547-551, 1998.
39. J Taylor, RA Johnston, FI Card. Surgical treatment of cervical spondylotic myelopathy in elderly people. Age Ageing 20:407-412, 1991.
40. RG Davidson. Atlantoaxial instability in individuals with Down syndrome: a fresh look at the evidence. Pediatrics 81:857-865, 1988.
41. RE Morton, M Ali Khan, C Murray-Leslie. Atlantoaxial instability in Down’s syndrome: a five-year follow-up study. Arch Dis Child 72:115-118, 1995.
42. PA Baird, AD Sadovnick. Underlying causes of death in Down syndrome: Accuracy of British Columbia death certificate data. Can J Public Health 81:456-461, 1990.
43. A Zipursky, A Poon, J Doyle. Leukemia in Down syndrome. Pediatr Hematol Oncol 9:139-149, 1992.
44. KP Dieckmann, C Rube, RP Henke. Association of Down’s syndrome and testicular cancer. J Urol 157:1701-1704, 1997.
45. D Satge, D Sommelet, A Geneix, M Nishi, P Malet, M Vekemans. A tumor profile in Down syndrome. Am J Med Genet 78:207-216, 1998.
46. DL Madden, EB Matthew, DE Dietzman. Hepatitis and Down’s syndrome. Am J Ment Defic 80:401-406, 1976.
47. F Renner, M Andrie, W Horak. Hepatitis A and B in non-institutionalised mentally retarded patients. Hepatogastroenterology 32:175-177, 1985.
48. P Chicon, L Crawford, WD Grimm. Early onset periodontitis associated with Down’s syndrome: clinical interventional study. Ann Periodontol 3:370-380, 1998.
49. SM Pueschel, JC Pezzulo. Thyroid dysfunction in Down syndrome. Am J Dis Child 139:636-639, 1985.
50. MM Loudon, RE Day, EM Duke. Thyroid disease in Down syndrome. Arch Dis Child 60:1149-1151, 1985.
51. B Karlsson, J Gustafsson, G Hedov, SA Ivarsson, G Anneren. Thyroid dysfunction in Down’s syndrome: relation to age and thyroid autoimmunity. Arch Dis Child 79:242-245, 1998.
52. S Dinani, S Carpenter. Down’s syndrome and thyroid disorder. J Ment Def Res 34:187-193, 1990.
53. JC Murdoch, WA Ratcliffe, DG McLarty. Thyroid function in adults with Down syndrome. J Clin Endocrinol Metab 44:453-458, 1977.
54. PA Baird, AD Sadovnick. Life expectancy in Down syndrome. J Pediatr 110:849-854, 1987.
55. PA Baird, AD Sadovnick. Life expectancy in Down syndrome adults. Lancet Dec 10:1354-1356, 1988.
56. PA Baird, AD Sadovnick. Life tables for Down syndrome. Hum Genet 82:291-292, 1989.
57. Q Yang, SA Rasmussen, JM Friedman. Racial disparities in median age at death of persons with Down syndrome—United States, 1968-1999. MMWR 50:463-465, 2001.
58. E Nakamura, S Tanaka. Biologic ages of adult men and women with DS and its changes with aging. Mech Ageing Dev 105:89-103, 1998.
59. KL Brugge, GL Grove, P Clopton, MJ Grove, DJ Piacquadio. Evidence for accelerated skin wrinkling among developmentally delayed individuals with DS. Mech Ageing Dev 70:213-225, 1993.
60. Online Mendelian Inheritance in Man: A catalog of human genes and genetic disorders, authored and edited by Victor McKusick and developed for the World Wide Web by NCBI.
61. WW Feaster, LW Kwok, CJ Epstein. Dosage effects for superoxide dismutase-1 in nucleated cells aneuploid for chromosome 21. Am J Hum Genet 29:563-570, 1977.
62. G Brodsky, T Barnes, J Bleskan, L Becker, M Cox, D Patterson. The human GARS-AIRS-GART gene encodes two proteins which are differentially expressed during human brain development and temporally overexpressed in cerebellum of individuals with DS. Hum Mol Genet 6:2043-2050, 1977.
63. DA Evans, HH Funkenstein, MS Albert, PA Scherr, NR Cook, MJ Chown, LE Hebert, CH Hennekens, JO Taylor. Prevalence of Alzheimer’s disease in a community population of older persons. JAMA 262:2551-2556, 1989.
64. JE Fisher, LL Carstensen. Behavior management for the dementias. Clin Psychol Rev 10:611-630, 1990.
65. MN Sabbagh, D Galasko, LJ Thal. B-amyloid and treatment opportunities for Alzheimer’s disease. Alzheimer’s Dis Rev 3:1-19, 1997.
66. G Van Gassen, C VanBroeckhoven. Molecular genetics of Alzheimer disease: what have we learned? Acta Neurol Belg 100:65-76, 2000.
67. P Heutink. Untangling tau-related dementia. Hum Mol Genet 9:979-986, 2000.
68. Y Sejijima, F Kametani, K Tanaka, M Okochi, M Usami, H Mori, T Tokuda, S Ikeda. Presenilin-1 exists in the axoplasm fraction in the brains of aged Down syndrome subjects and non-demented individuals. Neurosci Lett 267:121-124, 1999.
69. SM de la Monte. Molecular pathology of Down syndrome: abnormalities of the brain in Down syndrome relevance to Alzheimer’s neurodegenertaion. J Neural Transm 57(suppl):1-19, 1999.
70. VP Prasher, MJ Farrer, AM Kessling, EM Fisher, RJ West, PC Barber, AC Butler. Molecular mapping of Alzheimer-type dementia in Down’s syndrome. Ann Neurol 43:380, 1998.
71. FW van Leeuwen, EM Hol. Molecular misreading of genes in Down syndrome as a model for the Alzheimer type of neurodegeneration. J Neural Transm 57(suppl): 137-159, 1999.
72. F Oyama, NJ Cairns, H Shimada, R Oyama, K Titani, Y Ihara. Down’s syndrome: up-regulation of beta amyloid protein precursor and tau mRNAs and their defective coordination. J Neurochem 62:1062-1066, 1994.
73. BY Azizeh, E Head, MA Ibrahim, R Torp, AJ Tenner, RC Kim, IT Lott, CW Colt-man. Molecular dating of senile plaques in the brains of individuals with DS and aged dogs. Exp Neurol 163:111-122, 2000.
74. FW Van Leeuwen, EM Hol. Molecular misreading of genes in Down syndrome as a model for the Alzheimer type of neurodegeneration. J Neuol Transm 57(suppl): 137-159, 1999. Review.
75. J Lewis, DW Dickson, WL Lin, L Chisholm, A Corral, G Jones, SH Yes, N Sahara, L Skipper, D Yager, C Eckman, J Hardy, M Hutton, E McGowan. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant Tau and APP. Science 293:1487-1491, 2001.
76. J Gotz, F Chen, J van Dorpe, RM Nitsch. Formation of Neurofibrillary tangles in P301L Tau transgenic mice induced by A-beta42 fibrils. Science 293:1491-1495, 2001.
77. M Mattson. Modification of ion homeostasis by lipid peroxidation: roles in neuronal degeneration and adaptive plasticity. Trends Neurosci 20:53-57, 1998.
78. JB de Haan, F Cristiano, R Iannello, C Bladier, MJ Kelner, I Kola. Elevation in the ratio of Cu/Zn-superoxide dismutase to glutathione peroxidase activity induces features of cellular senescence and this effect is mediated by hydrogen peroxide. Hum Mol Genet 5:283-292, 1996.
79. NS Raji, KS Rao. Trisomy 21 and accelerated aging: DNA-repair parameters in peripheral lymphocytes of Down’s syndrome. Mech Ageing Dev 100:85-101, 1998.
80. SV Jovanovic, D Clements, K MacLeod. Biomarkers of oxidative stress significantly elevated in Down syndrome. Free Rad Biol Med 25:1044-1048, 1998.