The depressant scorpion neurotoxin LqqIT2 selectively modulates the insect voltage-gated sodium channel

Toxicon

Volumn 45, Issue 4, 2005, Pages 501-507

  Bosmans, Frank ^a   Martin Eauclaire, Marie France ^b   Tytgat, Jan ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b CNRS   (France)

Author keywords

Depressant scorpion toxin; Insecticide; LqqIT2

Indexed keywords

INSECTICIDE; SCORPION NEUROTOXIN LQQIT2; SCORPION VENOM; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL CELL; ARTICLE; BRAIN; CLONING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ELECTROPHYSIOLOGY; INSECT; INSECTICIDAL ACTIVITY; NONHUMAN; OOCYTE; PRIORITY JOURNAL; XENOPUS LAEVIS;

INSECTA; LEIURUS; LEIURUS QUINQUESTRIATUS QUINQUESTRIATUS; MAMMALIA; SCORPIONES; XENOPUS LAEVIS;

EID: 13944258544     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2004.12.010     Document Type: Article

References (45)

1. S.A. Ali, S. Stoeva, J.G. Grossmann, A. Abbasi, and W. Voelter Purification, characterization, and primary structure of four depressant insect-selective neurotoxin analogs from scorpion (Buthus sindicus) venom Arch. Biochem. Biophys. 391 2001 197 206
2. R. Benkhalifa, M. Stankiewicz, B. Lapied, M. Turkov, N. Zilberberg, M. Gurevitz, and M. Pelhate Refined electrophysiological analysis suggests that a depressant toxin is a sodium channel opener rather than a blocker Life Sci. 61 1997 819 830
3. A. Borges, M.J. Alfonzo, C.C. Garcia, N.J. Winand, E. Leipold, and S.H. Heinemann Isolation, molecular cloning and functional characterization of a novel beta-toxin from the Venezuelan scorpion, Tityus zulianus Toxicon 43 2004 671 684
4. F. Bosmans, A. Aneiros, and J. Tytgat The sea anemone Bunodosoma granulifera contains surprisingly efficacious and potent insect-selective toxins FEBS Lett. 532 2002 131 134
5. M.D. Cahalan Modification of sodium channel gating in frog myelinated nerve fibres by Centruroides sculpturatus scorpion venom J. Physiol. 244 1975 511 534
6. S.C. Cannon Voltage-gated ion channelopathies of the nervous system Clin. Neurosci. Res. 1 2001 104 117
7. W.A. Catterall From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels Neuron 26 2000 13 25
8. S. Cestèle, and W.A. Catterall Molecular mechanisms of neurotoxin action on voltage-gated sodium channels Biochimie 82 2000 883 892
9. S. Cestèle, Y. Qu, J.C. Rogers, H. Rochat, T. Scheuer, and W.A. Catterall Voltage-sensor trapping: enhanced activation of sodium channels by β-scorpion toxin bound to the S3-S4 loop in domain II Neuron 21 1998 919 931
10. + channels J. Biol. Chem. 279 2004 8206 8211
11. F. Couraud, E. Jover, J.M. Dubois, and H. Rochat Two types of scorpion toxin receptor sites, one related to the activation, the other to the inactivation of the action potential sodium channel Toxicon 20 1986 9 13
12. M.E. De Lima, M.F. Martin, C.R. Diniz, and H. Rochat Tityus serrulatus toxin TsVII bears pharmacological properties of both β-toxin and insect toxin from scorpion venom Biochem. Biophys. Res. Commun. 139 1986 296 302
13. M.E. De Lima, M.F. Martin-Euclaire, B. Hue, E. Loret, C.R. Diniz, and H. Rochat On the binding of two scorpion toxins to the central nervous system of the cockroach Periplaneta americana Insect Biochem. 19 1989 413 422
14. H. Denac, M. Mevissen, and G. Scholtysik Structure, function and pharmacology of voltage-gated sodium channels Naunyn Schmiedebergs Arch. Pharmacol. 362 2000 453 479
15. G. Feng, P. Deák, M. Chopra, and L. Hall Cloning and functional analysis of tipE, a novel membrane protein that enhances Drosophila para sodium channel function Cell 82 1995 1001 1011
16. O. Froy, N. Zilberberg, D. Gordon, M. Turkov, N. Gilles, M. Stankiewicz, M. Pelhate, E. Loret, D.A. Oren, B. Shaanan, and M. Gurevitz The putative bioactive surface of insect-selective scorpion excitatory neurotoxins J. Biol. Chem. 274 1999 5769 5776
17. D. Gordon, M.F. Martin-Eauclaire, S. Cestele, C. Kopeyan, E. Carlier, R. Ben Khalifa, M. Pelhate, and H. Rochat Scorpion toxins affecting sodium current inactivation bind to distinct homologous receptor sites on rat brain and insect sodium channels J. Biol. Chem. 271 1996 8034 8045
18. D. Gordon, P. Savarin, M. Gurevitz, and S. Zinn-Justin Functional anatomy of scorpion toxins affecting sodium channels J. Toxicol. Toxin Rev. 17 1998 131 159
19. D. Gordon, N. Ilan, N. Zilberberg, N. Gilles, D. Urbach, L. Cohen, I. Karbat, O. Froy, A. Gaathon, R.G. Kallen, M. Benveniste, and M. Gurevitz An 'old world' scorpion beta-toxin that recognizes both insect and mammalian sodium channels Eur. J. Biochem. 270 2003 2663 2670
20. C. Goudet, C.W. Chi, and J. Tytgat An overview of toxins and genes from the venom of the Asian scorpion Buthus martensi kirsch Toxicon 40 2002 1239 1258
21. + channels J. Exp. Biol. 204 2001 711 721
22. M. Gurevitz, D. Gordon, S. Ben-Natan, M. Turkov, and O. Froy Diversification of neurotoxins by C-tail 'wiggling': a scorpion recipe for survival FASEB J. 15 2001 1201 1205
23. B. Hille The permeability of the sodium channel to metal cations in myelinated nerve J. Gen. Physiol. 59 1972 637 658
24. + channels FASEB J. 18 2004 683 689
25. Y.J. Li, Z.Y. Tan, and Y.H. Ji The binding of BmK IT2, a depressant insect-selective scorpion toxin on mammal and insect sodium channels Neurosci. Res. 38 2000 257 264
26. + channel determined by construction of multimeric cDNAs Neuron 9 1992 861 871
27. S. Maeda, S.L. Volrath, T.N. Hanzlik, S.A. Harper, K. Majima, D.W. Maddox, B.D. Hammock, and E. Fowler Insecticidal effects of an insect-specific neurotoxin expressed by a recombinant baculovirus Virology 184 1991 777 780
28. T. Mejri, L. Borchani, N. Srairi-Abid, R. Benkhalifa, S. Cestèle, I. Regaya, H. Karoui, M. Pelhate, H. Rochat, and M. El Ayeb BotIT6: a potent depressant insect toxin from Buthus occitanus tunetanus venom Toxicon 41 2003 163 171
29. H. Moskowitz, R. Herrmann, A.D. Jones, and B.D. Hammock A depressant insect-selective toxin analog from the venom of the scorpion Leiurus quinquestriatus hebraeus-purification and structure/function characterization Eur. J. Biochem. 254 1998 44 49
30. S. Mouhat, B. Jouirou, A. Mosbah, M. De Waard, and J.M. Sabatier Diversity of folds in animal toxins acting on ion channels Biochem. J. 378 2004 717 726
31. M. Noda, T. Ikeda, T. Kayano, H. Suzuki, H. Takeshima, M. Kurasaki, H. Takahashi, and S. Numa Existence of distinct sodium channel messenger RNAs in rat brain Nature 320 1986 188 192
32. M. Pelhate, and E. Zlotkin Actions of insect toxin and other toxins derived from the venom of the scorpion Androctonus australis on isolated giant axons of the cockroach (Periplaneta americana) J. Exp. Biol. 97 1982 67 77
33. F. Peng, X.C. Zeng, X.H. He, J. Pu, W.X. Li, Z.H. Zhu, and H. Liu Molecular cloning and functional expression of a gene encoding an antiarrhythmia peptide derived from the scorpion toxin Eur. J. Biochem. 269 2002 4468 4475
34. +-channels Eur. J. Biochem. 264 1999 287 300
35. A. Regev, H. Rivkin, B. Inceoglu, E. Gershburg, B.D. Hammock, M. Gurevitz, and N. Chejanovsky Further enhancement of baculovirus insecticidal efficacy with scorpion toxins that interact cooperatively FEBS Lett. 537 2003 106 110
36. E.B. Stevens, P.J. Cox, B.S. Shah, A.K. Dixon, P.J. Richardson, R.D. Pinnock, and K. Lee Tissue distribution and functional expression of the human voltage-gated sodium channel β3 subunit Eur. J. Physiol. 441 2001 481 488
37. L.M. Stewart, M. Hirst, M. Lopez Ferber, A.T. Merryweather, P.J. Cayley, and R.D. Possee Construction of an improved baculovirus insecticide containing an insect-specific toxin gene Nature 352 1991 85 88
38. H. Vais, M.S. Williamson, A.L. Devonshire, and P.N.R. Usherwood The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels Pest Manage. Sci. 57 2001 877 888
39. C.G. Wang, M.H. Ling, C.W. Chi, D.C. Wang, and M. Pelhate Purification of two depressant insect neurotoxins and their gene cloning from the scorpion Buthus martensi Karsch J. Pept. Res. 61 2003 7 16
40. J.W. Warmke, R.A.G. Reenan, P. Wang, S. Qian, J.P. Arena, J. Wang, D. Wunderler, K. Liu, J.P. Kaczorowski, L.H.T. Van Der Ploeg, B. Ganetzky, and C.J. Cohen Functional expression of Drosophila para sodium channels. Modulation by the membrane protein tipE and toxin pharmacology J. Gen. Physiol. 110 1997 119 133
41. W.M. Weber Ion currents of Xenopus laevis oocytes: state of the art Biochim. Biophys. Acta 1421 1999 213 233
42. E. Zlotkin The insect voltage-gated sodium channel as target of insecticides Annu. Rev. Entomol. 44 1999 429 455
43. E. Zlotkin, D. Kadouri, D. Gordon, M. Pelhate, M.F. Martin, and H. Rochat An excitatory and a depressant insect toxin from scorpion venom both affect sodium conductance and possess a common binding site Arch. Biochem. Biophys. 240 1985 877 887
44. E. Zlotkin, M. Eitan, V.P. Bindokas, M.E. Adams, M. Moyer, W. Burkhart, and E. Fowler Functional duality and structural uniqueness of depressant insect-selective neurotoxins Biochemistry 30 1991 4814 4820
45. E. Zlotkin, Y. Fishman, and M. Elazar AaIT: from neurotoxin to insecticide Biochimie 82 2000 869 881