AaIT: From neurotoxin to insecticide

Biochimie

Volumn 82, Issue 9-10, 2000, Pages 869-881

  Zlotkin, Eliahu ^a   Fishman, Yelena ^a   Elazar, Menashe ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

INSECTICIDE; NEUROTOXIN; SCORPION VENOM; VOLTAGE GATED CHANNEL FORMING PROTEIN;

BACULOVIRUS; BINDING AFFINITY; BINDING SITE; CHANNEL GATING; CROSS LINKING; DISULFIDE BOND; ENVENOMATION; INSECT; INSECT CONTROL; INSECTICIDE RESISTANCE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PURIFICATION; REVIEW; SODIUM CONDUCTANCE; TOXIN ANALYSIS; TOXIN STRUCTURE;

ANDROCTONUS; ANDROCTONUS AUSTRALIS HECTOR; BUTHIDAE; HEXAPODA; INSECTA; INVERTEBRATA; SCORPIONES; UNIDENTIFIED BACULOVIRUS;

EID: 0033731922     PISSN: 03009084     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-9084(00)01177-9     Document Type: Review

References (108)

1. Neurotoxins that act on voltage sensitive sodium channels in excitable membranes
2. The insect voltage gated channel as target of insecticides
3. Actions of insecticides on sodium channels: Multiple target sites and site specific resistance
4. Cellular and molecular biology of voltage-gated sodium channels
5. Sodium channels as targets for neurotoxins: Mode of action and interaction of neurotoxins with receptor sites on sodium channels
6. Conotoxins as probes of channel subtypes
7. Functional anatomy of scorpion toxins affecting sodium channels
8. A scorpion α-like toxin that is active on insects and mammals reveals an unexpected specificity and distribution of sodium channel subtypes in rat brain neurons
9. Purification and properties of the insect toxin from the venom of the scorpion Androctonus australis Hector
10. Purification and characterization of a new family of polypeptide neurotoxins from the heteronemertine Cerebratulus lacteus (Leidy)
11. Purification and pharmacological properties of eight sea anemone toxins from Anemonia sulcata, Anthopleura xanthogrammica, Stoichactis giganeus and Actinodendron plumsosian
12. Neurotoxins
13. Studies of the venoms of some Conidae
14. Mollusc specific toxins from the venom of Conus textile neovicarius
15. A new neurotoxin receptor site on channels is identified by a conotoxin that affects sodium channel inactivation in molluscs, and acts as an antagonist in rat brain
16. Interactions of delta-conotoxin with alkaloid neurotoxins reveal differences between the silent and effective binding sites on voltage-sensitive sodium channels
17. The structure of a novel insecticidal neurotoxin, a atracotoxin-HVI from the venom of an Australian funnel web spider
18. Structure function studies of omega atracotoxin a potent antagonist of insect voltage gated calcium channels
19. Guest editorial: Venom neurotoxins - Models for selective insecticides
20. A factor toxic to crustaceans in the venom of the scorpion Androctonus australis Hector
21. Estimation of locusts resistance to scorpion venom
22. Proteins in scorpion venoms toxic to mammals and insects
23. The effect of scorpion venom on blowfly larvae; A new method for the evaluation of scorpion venom potency
24. Effects of venom on nerve muscles and neuromuscular junction
25. Physiological effects of venom of Leiurus quinquestriatus on neuromuscular systems of locust and crab
26. The effect of scorpion venom on the neuromuscular junction of the frog
27. Effects and mechanism of action of Tityus serrulatus venom on skeletal muscle
28. Chemistry specificity and action of arthropod toxin proteins derived from scorpion venoms
29. Purification and some properties of the neurotoxins of Androctonus australis Hector
30. Purification of animal neurotoxins. Isolation and characterization of eleven neurotoxins from the venom of the scorpion Androctonus australis Hector, Buthus occitanus tunetatus and Leiurus quinquestriatus
31. A new toxic protein in the venom of the scorpion Androctonus australis Hector
32. The pharmacological flexibility of the insect voltage gated sodium channel: Toxicity of AaIT to knockdown resistant (kdr) flies
33. A protein toxin to crustacea from the venom of the scorpion Androctonus australis
34. Toxicity to crustacea due to polypeptide-phospholipase interaction in the venom of a chactoid scorpion
35. Covalent structure of the insect toxin of the North African scorpion Androctonus australis Hector
36. Detection, purification and receptor binding assays of insect selective neurotoxins derived from scorpion venoms
37. The interaction of insect selective neurotoxins from scorpion venoms with insect neuronal membranes
38. Action of different toxins from the scorpion Androctonus australis on a locust nervemuscle preparation
39. The effect of different toxins from scorpion venom on neuromuscular transmission and nerve action potentials in the crayfish
40. The effect of toxins from the venom of the scorpion Androctonus australis on a spider nerve-muscle preparation
41. The action of toxins derived from scorpion venom on the ileal smooth muscle preparation
42. Selective binding of the scorpion venom insect toxin to insect nervous tissue
43. Accessibility of the insect nervous system to a neurotoxic popypeptide
44. Functional duality and structural uniqueness of depressant insect-selective neurotoxins
45. The effect of scorpion venom and pure toxin on the cockroach central nervous system
46. + current in the cockroach giant axon induced by the scorpion venom 'insect' toxin
47. Actions of insect toxin and other toxins derived from the venom of the scorpion Androctonus australis in isolated giant axons of the cockroach (Periplaneta americana)
48. The binding of the insect selective neurotoxin (AaIT) from scorpion venom to locust synaptosomal membranes
49. The binding of an insect-selective neurotoxin and saxitoxin to insect neuronal membranes
50. Localization of receptor sites for insect selective toxins on sodium channels by site directed antibodies
51. Insect sodium channel as the target for insect-selective neurotoxins from scorpion venom
52. Neurogenetic analysis of Drosophila mutations affecting sodium channels: Synergistic effects on viability and nerve conduction in double mutants involving tip E
53. Alterations in the expression and gating of Drosophila sodium channels by mutations in the paragene
54. Molecular analysis of the para locus, a sodium channel gene in Drosophila
55. Structure-function studies of voltage-gated ion channels
56. Structure and function of voltage gated sodium and calcium channels
57. Effects of external cations and mutations in the pore region on C-type inactivation of shaker potassium channels
58. Purification, characterization and action of two insect toxins from the venom of the scorpion, Buthotus judaicus
59. Late sodium current induced by scorpion toxins and pyrethroid insecticides in insect neuronal membrane
60. A new approach to insect-pest control - Combination of neurotoxins interacting with voltage sensitive sodium channels to increase selectivity and specificity
61. Tityus serrulatus toxin VII bears pharmacological properties of both β-toxin and insect toxin from scorpion venoms
62. Three dimensional structure of a protein from scorpion venom: A new structural class of neurtoxins
63. Orthorhombic crystals and three-dimensional structure of the potent toxin II from the scorpion Androctonus australis Hector
64. Three-dimensional model of the insect-directed scorpion toxin from Androctonus australis Hector and its implications for the evolution of scorpion toxins in general
65. The three-dimensional structure of scorpion neurotoxins
66. Structure-function relationships in scorpion neurotoxins: Identification of the superlative lysine residue in toxin of androctonus australis Hector
67. Structure-function relationships of scorpion neurotoxins
68. Scorpion neurotoxins: Effects and mechanisms
69. 1H nuclear magnetic resonance. Resonance assignment and secondary structure
70. Toxin III of the scorpion Androctonus australis Hector: Proton magnetic resonance assignments and secondary structure
71. Structure of scorpion toxin variant 3 at 1.2. A resolution
72. Functional anatomy of scorpion toxins affecting sodium channels
73. Neurotoxins active on insects: Amino acid sequences, chemical modifications, and secondary structure estimation by circular dichroism of toxins from the scorpion androctonus australis hector
74. Conformational flexibility of a scorpion toxin active on mammals and insects: A circular dichroism study
75. The putative bioactive surface of insect-selective scorpion excitatory neurotoxins
76. 1H nuclear magnetic resonance study of AaH IT, an anti-insect toxin from the scorpion Andoctonus australis Hector. Sequential resonance assignments and folding of the polypeptide chain
77. The tolerance of lipidopterous larvae to an insect selective neurotoxin
78. Insect tolerance to a neurotoxic polypeptide: Pharmacokinetic and pharmacodynamic aspects
79. Field trial of a genetically improved baculovirus insecticide
80. Expression of foreign genes in insects using baculovirus vectors
81. Construction of an improved baculovirus insecticide containing an insect-specific toxin gene
82. Development of a recombinant baculovirus expressing an insect selective neurotoxin: Potential for pest control
83. Development of recombinant baculoviruses for insect-control
84. Insect paralysis by baculovirus-mediated expression of a mite neurotoxin gene
85. Properties of three baculovirus-expressing genes that encode insect-selective toxins: μ-Aga-IV, As II and Sh I
86. Characterization and cloning of insecticidal peptides from the primitive weaving spider Diguelia canites
87. Baculovirus mediated expression of a scorpion depressant toxin improves the insecticidal efficacy achieved with excitatory toxins
88. The insect tracheal system: A conduit for systemic spread of Autographa california M nuclear polyhedrosis virus
89. Primary infection of insect tracheae by Autographa californica M nuclear polyhedrosis virus
90. Characterization of a cytochrome p450 responsible for pyrethroid resistance in the housefly
91. Identification of mutations in the housefly para type sodium channel gene associated with knockdown resistance (kdr) to pyrethroid insecticides
92. Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyrethroid insecticides
93. Linkage of pyrethroid insecticide resistance to a sodium channel locus in the tobacco budworm
94. A single amino-acid change in the para sodium channel protein is associated with knock down resistance (kdr) to pyrethroid insecticides in German cockroach
95. Positive cooperativity among insecticidal scorpion neurotoxins
96. Insecticidal amides with selective potency against a resistant (Super-kdr) strain of houseflies
97. Interaction of recombinant and wild type baculoviruses with classical insectides and pyrethroid resistant tobacco budworms (Lepidoptera, Noctuidae)
98. Dynamic diversification from a putative common ancestor of scorpion toxins affecting sodium, potassium and chloride channels
99. Primary structure of scorpion anti-insect toxins isolated from the venom of Leiurus quinquestriatus quinquestriatus
100. The cDNA sequence of an excitatory insect selective neurotoxin from the scorpion Buthus martensi Karsch
101. Molecular characterization of a new excitatory insect neurotoxin with an analgesic effect on mice from the scorpion Buthus martensi Karsch
102. Transgenic plants expressing insecticide proteins
103. Further studies of the venoms of some Conidae