A new method for estimating the importance of hydrophobic groups in the binding site of a protein

Journal of Medicinal Chemistry

Volumn 48, Issue 4, 2005, Pages 1069-1078

  Kelly, Matthew D ^a   Mancera, Ricardo L ^b,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b De Novo Pharmaceuticals Ltd   (United Kingdom)

^c CURTIN UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 10A; CARBONATE DEHYDRATASE II; CARBOXYPEPTIDASE; PROTEINASE; TRYPSIN;

ALGORITHM; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; ENTHALPY; HYDROGEN BOND; HYDROPHOBICITY; PARAMETER; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SURFACE PROPERTY; VALIDATION PROCESS;

ALGORITHMS; BINDING SITES; CARBONIC ANHYDRASES; CARBOXYPEPTIDASES; FACTOR XA; HIV PROTEASE; HYDROPHOBICITY; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEINS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SOLVENTS; TRYPSIN;

EID: 13944250570     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049524q     Document Type: Article

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