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85030806728
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note
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No yield has been reported for the synthesis of diamine (R,R)-16
-
-
-
-
30
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85030813146
-
-
note
-
This tetrabenzyldiamine (R,R)-22 was synthesised in four steps with an overall yield of 38%; first step-imine formation (R,R)-10 (83%), second step-diamine formation (R,R)-8 (90%), third step-amide formation (R,R)-21 (65%) and fourth step (R,R)-22 (79%)-amide reduction
-
-
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33
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0023929950
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C.R. Clark, P.R. Halfpenny, R.G. Hill, D.C. Horwell, J. Hughes, T.C. Jarvis, D.C. Rees, and D. Schofield J. Med. Chem. 31 1988 831 For additional methods for the synthesis of achiral tertiary amines see Ref. [28]
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