De novo design of an IL-4 antagonist and its structure at 1.9 Å

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 6, 2005, Pages 1889-1894

  LaPorte, Sherry L ^a   Forsyth, Charles M ^a   Cunningham, Brian C ^b   Miercke, Larry J ^a   Akhavan, David ^a   Stroud, Robert M ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Sunesis Inc   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

De novo protein design; Helical bundle; IL 4 receptor; Structure based design

Indexed keywords

CYTOKINE RECEPTOR ANTAGONIST; INTERLEUKIN 4; INTERLEUKIN 4 ANTAGONIST; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN 4 RECEPTOR ALPHA; PROTEIN; PROTEIN DHP 1; PROTEIN DHP 14 AB; UNCLASSIFIED DRUG;

ARTICLE; ASTHMA; BINDING COMPETITION; DRUG BINDING SITE; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG TARGETING; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; RECEPTOR AFFINITY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; INTERLEUKIN-4; MODELS, MOLECULAR; PROTEIN ENGINEERING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEINS; RECEPTORS, INTERLEUKIN-4;

EID: 13844307891     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0408890102     Document Type: Article

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