Global and local determinants for the kinetics of interleukin-4/interleukin-4 receptor α chain interaction a biosensor study employing recombinant interleukin-4-binding protein

European Journal of Biochemistry

Volumn 240, Issue 1, 1996, Pages 252-261

  Shen, Bo Jiang ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Electrostatic steering; Interleukin 4 receptor; Interleukin 4 variants; Plasmon resonance; Rate constants

Indexed keywords

BINDING PROTEIN; INTERLEUKIN 4 RECEPTOR;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BIOSENSOR; CELL LINE; CHO CELL; CONTROLLED STUDY; ESCHERICHIA COLI; GENE CONSTRUCT; GENE EXPRESSION; KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PURIFICATION; PROTEIN VARIANT; RECEPTOR BINDING; TECHNIQUE;

ANIMALS; ANTIGENS, CD; BIOSENSING TECHNIQUES; CELL LINE; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; ESCHERICHIA COLI; HUMANS; HYDROGEN-ION CONCENTRATION; INTERLEUKIN-4; KINETICS; MACROMOLECULAR SUBSTANCES; MOLECULAR WEIGHT; MUTAGENESIS, SITE-DIRECTED; OSMOLAR CONCENTRATION; POINT MUTATION; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-4; RECOMBINANT PROTEINS; SPODOPTERA; THERMODYNAMICS; TRANSFECTION; VARIATION (GENETICS);

EID: 0029818648     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1996.0252h.x     Document Type: Article

References (3)

1. Bamborough, P., Hedgecock, C. Jr & Richards, W. G. (1994) The interleukin-2 and interleukin-4 receptors studied by molecular modelling, Structure 2, 839-851.
2. Bazan, J. F. (1990) Structural design and molecular evolution of a cytokine receptor superfamily, Proc. Natl Acad. Sci. USA 87, 6934-6938.
3. Beckmann, M. P., Cosman, D., Fanslow, W., Maliszewski, C. R. & Lyman, S. D. (1992) The interleukin-4 receptor: structure, function, and signal transduction, Chem. Immunol. 51, 107-134.