Metabolism of phenanthrene by house fly CYP6D1 and dog liver cytochrome P450

Journal of Biochemical and Molecular Toxicology

Volumn 14, Issue 1, 2000, Pages 20-25

  Korytko, Peter J ^a   Quimby, Fred W ^a   Scott, Jeffrey G ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

Cytochrome P450 Monooxygenases; Dog; House Fly; Polycyclic Aromatic Hydrocarbon Metabolism

Indexed keywords

CYP6D1 PROTEIN, MUSCA DOMESTICA; CYTOCHROME P450; INSECT PROTEIN; PHENANTHRENE; PHENANTHRENE DERIVATIVE;

ANIMAL; ARTICLE; AUTORADIOGRAPHY; DOG; ENZYMOLOGY; FEMALE; FLUOROMETRY; HOUSE FLY; LIVER MICROSOME; METABOLISM;

ANIMALS; AUTORADIOGRAPHY; CYTOCHROME P-450 ENZYME SYSTEM; DOGS; FEMALE; FLUOROMETRY; HOUSEFLIES; INSECT PROTEINS; MICROSOMES, LIVER; PHENANTHRENES;

EID: 0033987319     PISSN: 10956670     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1099-0461(2000)14:1<20::aid-jbt3>3.3.co;2-4     Document Type: Article

References (19)

1. Dean JH, Murray MJ. Toxic responses of the immune system. In: Amdur MO, Doull J, Klassen CD, editors. Casarett and Doull's toxicology: the basic science of poisons. New York: Pergamon Press; 1991. p 282-333.
2. Williams GM, Weisburger JH. 1991. Chemical carcinogenesis. In: Amdur MO, Doull J, Klassen CD, editors. Casarett and Doull's toxicology: the basic science of poisons. New York: Pergamon Press; 1991. p 127-200.
3. Nelson DR, Koymans L, Kamataki T, Stegeman JJ, Feyereisen R, Waxman DJ, Waterman MR, Gotoh O, Coon MJ, Estabrook RW, Gunsalus IC, Nebert DW. (1996). P450 superfamily: update on new sequences, gene mapping, accession numbers, and nomenclature. Pharmacogenetics 1996; 6:1-42.
4. Rendic S, Di Carlo FJ. Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors. Drug Metab Rev 1997;29:413-580.
5. Hodgson E, Rose RL, Ryu D-Y, Falls G, Blake BL, Levi PE. Pesticide-metabolizing enzymes. Toxicol Lett 1995;82/83:73-81.
6. Zimniak P, Waxman DJ. Liver cytochrome P450 metabolism of endogenous steroid hormones, bile acids, and fatty acids. In: Schenkman JB, Greim H, editors. Cytochrome P450. New York: Springer-Verlag; 1993. p 123-144
7. Sipes G, Gandolfi, AJ. Biotransformation of toxicants. In: Amdur MO, Doull J, Klassen CD, editors. Casarett and Doull's toxicology: the basic science of poisons. New York: Pergamon Press; 1991. p 88-126.
8. Agosin M. Role of microsomal oxidations in insecticide degradation. In: Kerkut GA, Gilbert LI, editors. Volume 12, Comprehensive insect physiology, biochemistry, and pharmacology. New York: Pergamon; 1985. p 647-712.
9. Hodgson E. Microsomal mono-oxygenases. In: Kerkut GA, Gilbert LI, editors. Volume 11, Comprehensive insect physiology, biochemistry, and pharmacology. Oxford: Pergamon; 1985. p 647-712.
10. Scott JG, Liu N, Wen Z. Insect cytochromes P450: biodiversity, tolerance to plant allelochemicals, and insecticide resistance. Comp Biochem Physiol 1998;121C; 147-155.
11. Wheelock GD, Konno Y, Scott JG. Expression of cytochrome P-4501pr is developmentally regulated and limited to house fly. J Biochem Toxicol 1991;6(4):239-246.
12. Wheelock GD, Scott JG. Anti-P4501pr antiserum inhibits specific monooxygenase activities in LPR house fly microsomes. J Exp Zool 1992;264:153-158.
13. Smith FF, Scott JG. Functional expression of the house fly (Musca domestica) cytochrome P450 CYP6D1 in yeast (Saccharomyces cerevisiae). Insect Biochem Molec Biol 1997;27(12):999-1006.
14. Hatano R, Scott JG. Anti-P4501pr antiserum inhibits the activation of chlorpyrifos to chlorpyrifos oxon in house fly microsomes. Pestic Biochem Physiol 1993;45:228-233.
15. Wheelock GD, Scott JG. The role of cytochrome P4501prin deltamethrin metabolism by pyrethroid-resistant and susceptible strains of house fly. Pestic Biochem Physiol 1992;43:67-77.
16. Zhang M, Scott JG. Cytochrome b5 is essential for cytochrome P450 CYP6D1- mediated cypermethrin resistance in LPR house flies. Pestic Biochem Physiol 1996;55:150-156.
17. Korytko PJ, Scott JG. CYP6D1 protects thoracic ganglia of house flies from the neurotoxic insecticide cypermethrin. Arch Insect Biochem Physiol 1998;37:57-63.
18. Gelboin HV, Krausz KW, Goldfarb I, Buters JTM, Yang SK, Gonzalez FJ, Korzekwa K, Shou M. Inhibitory and noninhibitory monoclonal antibodies to human cytochrome P450 3A3/4. Biochem Pharmacol 1995:50(11):1841-1850.
19. Gelboin HV, Goldfarb I, Krausz KW, Grogan J, Korzekwa KR, Gonzalez FJ, Shou M. Inhibitory and noninhibitory monoclonal antibodies to human cytochrome P450 2E1. Chem Res Toxicol 1996;9:1023-1030.