Analysis of human Pex19p's domain structure by pentapeptide scanning mutagenesis

Journal of Molecular Biology

Volumn 346, Issue 5, 2005, Pages 1275-1286

  Fransen, Marc ^a   Vastiau, Ilse ^a   Brees, Chantal ^a   Brys, Vanessa ^a   Mannaerts, Guy P ^a   Van Veldhoven, Paul P ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Biogenesis; Peroxisomes; Pex19p; Protein import; Transposon mutagenesis

Indexed keywords

CHAPERONE; MEMBRANE PROTEIN; PENTAPEPTIDE; PEROXIN; PEROXIN 11; PEROXIN 12; PEROXIN 13; PEROXIN 14; PEROXIN 16; PEROXIN 19; PEROXIN 26; PEROXIN 3; PEROXIN 5; UNCLASSIFIED DRUG;

ALLELE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE TRANSPORT; CONTROLLED STUDY; ESCHERICHIA COLI; GENE INSERTION; GENE LIBRARY; GENETIC CODE; GENETIC VARIABILITY; MOUSE; NONHUMAN; OBSERVATION; OPEN READING FRAME; PEROXISOME; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; TRANSPOSON;

EID: 13844281618     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2005.01.013     Document Type: Article

References (45)

1. G.P. Mannaerts, P.P. Van Veldhoven, and M. Casteels Peroxisomal lipid degradation via beta- and alpha-oxidation in mammals Cell Biochem. Biophys. 32 2000 73 87
2. R.J. Wanders Metabolic and molecular basis of peroxisomal disorders: a review Am. J. Med. Genet. 126 2004 355 375
3. S. Weller, S.J. Gould, and D. Valle Peroxisome biogenesis disorders Annu. Rev. Genomics Hum. Genet. 4 2003 165 211
4. B. Distel, R. Erdmann, S.J. Gould, G. Blobel, D.I. Crane, and J.M. Cregg A unified nomenclature for peroxisome biogenesis factors J. Cell Biol. 135 1996 1 3
5. N. Matsumoto, S. Tamura, and Y. Fujiki The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase complexes to peroxisomes Nature Cell Biol. 5 2003 454 460
6. S.R. Terlecky, and M. Fransen How peroxisomes arise Traffic 1 2000 465 473
7. L.A. Brown, and A. Baker Peroxisome biogenesis and the role of protein import J. Cell. Mol. Med. 7 2003 388 400
8. W. Schliebs, and W.H. Kunau Peroxisome membrane biogenesis: the stage is set Curr. Biol. 14 2004 R397 R399
9. J. Moyersoen, J. Choe, E. Fan, G.J. Hol, and P.A. Michels Biogenesis of peroxisomes and glycosomes: trypanosomatid glycosome assembly is a promising new drug target FEMS Microbiol. Rev. 28 2004 603 643
10. A. Braun, S. Kammerer, W. Weissenhorn, E.H. Weiss, and H. Cleve Sequence of a putative human housekeeping gene (HK33) localized on chromosome 1 Gene 146 1994 291 295
11. W.B. Snyder, A. Koller, A.J. Choy, and S. Subramani The peroxin Pex19p interacts with multiple, integral membrane proteins at the peroxisomal membrane J. Cell Biol. 149 1999 1171 1178
12. K.A. Sacksteder, J.M. Jones, S.T. South, X. Li, Y. Liu, and S.J. Gould PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis J. Cell Biol. 148 2000 931 944
13. C.J. Gloeckner, P.U. Mayerhofer, P. Landgraf, A.C. Muntau, A. Holzinger, and J.K. Gerber Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p Biochem. Biophys. Res. Commun. 271 2000 144 150
14. M. Fransen, T. Wylin, C. Brees, G.P. Mannaerts, and P.P. Van Veldhoven Human Pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences Mol. Cell. Biol. 21 2001 4413 4424
15. M. Fransen, C. Brees, K. Ghys, L. Amery, G.P. Mannaerts, D. Ladant, and P.P. Van Veldhoven Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay Mol. Cell. Proteomics 1 2002 243 252
16. P.U. Mayerhofer, T. Kattenfeld, A.A. Roscher, and A.C. Muntau Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly Biochem. Biophys. Res. Commun. 291 2002 1180 1186
17. A.C. Muntau, A.A. Roscher, W.H. Kunau, and G. Dodt The interaction between human PEX3 and PEX19 characterized by fluorescence resonance energy transfer (FRET) analysis Eur. J. Cell Biol. 82 2003 333 342
18. Y. Matsuzono, N. Kinoshita, S. Tamura, N. Shimozawa, M. Hamasaki, and K. Ghaedi Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly Proc. Natl Acad. Sci. USA 96 1999 2116 2121
19. N. Shimozawa, Y. Suzuki, Z. Zhang, A. Imamura, N. Kondo, and N. Kinoshita Genetic basis of peroxisome-assembly mutants of humans. Chinese hamster ovary cells, and yeast: identification of a new complementation group of peroxisome-biogenesis disorders apparently lacking peroxisomal-membrane ghosts Am. J. Hum. Genet. 63 1998 1898 1903
20. E.H. Hettema, W. Girzalsky, M. van Den Berg, R. Erdmann, and B. Distel Saccharomyces cerevisiae Pex3p and Pex19p are required for proper localization and stability of peroxisomal membrane proteins EMBO J. 19 2000 223 233
21. J.M. Jones, J.C. Morrell, and S.J. Gould PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins J. Cell Biol. 164 2004 57 67
22. H. Rottensteiner, A. Kramer, S. Lorenzen, K. Stein, C. Landgraf, R. Volkmer-Engert, and R. Erdmann Peroxisomal membrane proteins contain common Pex19p-binding sites that are an integral part of their targeting signals Mol. Biol. Cell 15 2004 3406 3417
23. U. Brosius, T. Dehmel, and J. Gartner Two different targeting signals direct human peroxisomal membrane protein 22 to peroxisomes J. Biol. Chem. 277 2002 774 784
24. M. Biermanns, and J. Gartner Targeting elements in the amino-terminal part direct the human PMP70-kDa peroxisomal integral membrane protein (PMP70) to peroxisomes Biochem. Biophys. Res. Commun. 285 2001 649 655
25. G.R. Lambkin, and R.A. Rachubinski Yarrowia lipolytica cells mutant for the peroxisomal peroxin Pex19p contain structures resembling wild-type peroxisomes Mol. Biol. Cell 12 2001 3353 3364
26. M. Otzen, U. Perband, D. Wang, R.J. Baerends, W.H. Kunau, M. Veenhuis, and I.J. Van der Klei Hansenula polymorpha Pex19p is essential for the formation of functional peroxisomal membranes J. Biol. Chem. 279 2004 19181 19190
27. M. Fransen, I. Vastiau, C. Brees, V. Brys, G.P. Mannaerts, and P.P. Van Veldhoven Potential role for Pex19p in assembly of PTS-receptor docking complexes J. Biol. Chem. 279 2004 12615 12624
28. F. Hayes, and B. Hallet Pentapeptide scanning mutagenesis: encouraging old proteins to execute unusual tricks Trends Microbiol. 8 2000 571 577
29. K. Gotte, W. Girzalsky, M. Linkert, E. Baumgart, S. Kammerer, W.H. Kunau, and R. Erdmann Pex19p, a farnesylated protein essential for peroxisome biogenesis Mol. Cell. Biol. 18 1998 616 628
30. W.B. Snyder, K.N. Faber, T.J. Wenzel, A. Koller, G.H. Luers, and L. Rangell Pex19p interacts with Pex3p and Pex10p and is essential for peroxisome biogenesis in Pichia pastoris Mol. Biol. Cell 10 1999 1745 1761
31. Y. Fang, J.C. Morrell, J.M. Jones, and S.J. Gould PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins J. Cell Biol. 164 2004 775 863
32. B. Hallet, D.J. Sherratt, and F. Hayes Pentapeptide scanning mutagenesis: random insertion of a variable five amino acid cassette in a target protein Nucl. Acids Res. 25 1997 1866 1867
33. C. Manoil, and J. Bailey A simple screen for permissive sites in proteins: analysis of Escherichia coli lac permease J. Mol. Biol. 267 1997 250 263
34. H. Shibata, Y. Kashiwayama, T. Imanaka, and H. Kato Domain architecture and activity of human Pex19p, a chaperone-like protein for intracellular trafficking of peroxisomal membrane proteins J. Biol. Chem. 279 2004 38486 38494
35. W. Schliebs, J. Saidowsky, B. Agianian, G. Dodt, F.W. Herberg, and W.H. Kunau Recombinant human peroxisomal targeting signal receptor PEX5: structural basis for interaction of PEX5 with PEX14 J. Biol. Chem. 274 1999 5666 5673
36. J. Saidowsky, G. Dodt, K. Kirchberg, A. Wegner, W. Nastainczyk, W.H. Kunau, and W. Schliebs The di-aromatic pentapeptide repeats of the human peroxisome import receptor PEX5 are separate high affinity binding sites for the peroxisomal membrane protein PEX14 J. Biol. Chem. 276 2001 34524 34529
37. H. Otera, K. Setoguchi, M. Hamasaki, T. Kumashiro, N. Shimizu, and Y. Fujiki Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import Mol. Cell. Biol. 22 2002 1639 1655
38. J. Choe, J. Moyersoen, C. Roach, T.L. Carter, E. Fan, P.A.M. Michels, and W.G.J. Hol Analysis of the sequence motifs responsible for the interactions of peroxins 14 and 5, which are involved in glycosome biogenesis in Trypansoma brucei Biochemistry 42 2003 10915 10922
39. T. Sugihara, S.C. Kaul, J. Kato, R.R. Reddel, H. Nomura, and R. Wadhwa Pex19p dampens the p19ARF-p53-p21WAF1 tumor suppressor pathway J. Biol. Chem. 276 2001 18649 18652
40. R. Wadhwa, T. Sugihara, M.K. Hasan, K. Taira, R.R. Reddel, and S.C. Kaul A major functional difference between the mouse and human ARF tumor suppressor proteins J. Biol. Chem. 277 2002 36665 36670
41. M. Ito, S. Iidawa, M. Izuka, S. Haito, H. Segawa, and M. Kuwahata Interaction of a farnesylated protein with renal type IIa Na/Pi co-transporter in response to parathyroid hormone and dietary phosphate Biochem. J. 377 2004 607 616
42. L. Amery, H. Sano, G.P. Mannaerts, J. Snider, J. Van Looy, M. Fransen, and P.P. Van Veldhoven Identification of PEX5p-related novel peroxisome-targeting signal 1 (PTS1)-binding proteins in mammals Biochem. J. 357 2001 635 646
43. M. Fransen, P.P. Van Veldhoven, and S. Subramani Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase Biochem. J. 340 1999 561 568
44. M. Baes, P. Gressens, E. Baumgart, P. Carmeliet, M. Casteels, and M. Fransen A mouse model for Zellweger syndrome Nature Genet. 17 1997 49 57
45. J.M. Stultz, J.V. White, and T.F. Smith Structural analysis based on state-space modeling Protein Sci. 2 1993 305 314