Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly

Biochemical and Biophysical Research Communications

Volumn 291, Issue 5, 2002, Pages 1180-1186

  Mayerhofer, Peter U ^a   Kattenfeld, Tanja ^a   Roscher, Adelbert A ^a   Muntau, Ania C ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

ABC half transporter; Farnesylation; Peroxin; Peroxisomal membrane proteins; Peroxisome biogenesis disorders; PEX; Splice variants

Indexed keywords

ABC TRANSPORTER; COMPLEMENTARY DNA; PROTEIN; PROTEIN PEX19; PROTEIN PEX3; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; BIOGENESIS; CONTROLLED STUDY; FIBROBLAST; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; PEROXISOME; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION;

EID: 0036296472     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2002.6568     Document Type: Article

References (23)

1. Components involved in peroxisome import, biogenesis, proliferation, turnover, and movement
2. The life cycle of the peroxisome
3. Peroxisome biogenesis
4. Defective peroxisome membrane synthesis due to mutations in human PEX3 causes Zellweger syndrome, complementation group G
5. Peroxisome synthesis in the absence of preexisting peroxisomes
6. Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly
7. PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis
8. Pex19p, a farnesy-lated protein essential for peroxisome biogenesis
9. Pex19p interacts with Pex3p and Pex10p and is essential for peroxisome biogenesis in Pichia pastoris
10. Pex17p is required for import of both peroxisome membrane and lumenal proteins and interacts with pex19p and the peroxisome targeting signal-receptor docking complex in Pichia pastoris
11. Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p
12. The peroxin Pex19p interacts with multiple, integral membrane proteins at the peroxisomal membrane
13. Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences
14. Identification and characterization of the human peroxin PEX3
15. Saccharomyces cerevisiae pex3p and pex19p are required for proper localization and stability of peroxisomal membrane proteins
16. Genomic organization and molecular characterization of a gene encoding HsPXF, a human peroxisomal farnesylated protein
17. Alternative splice variants of cytokines: Making a list
18. Expression and characterization of splice variants of PYK2, a focal adhesion kinase-related protein
19. Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps
20. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
21. Cloning and characterization of the gene encoding the human peroxisomal assembly protein Pex3p
22. Sequence of a putative human housekeeping gene (HK33) localized on chromosome 1
23. Two different targeting signals direct human PMP22 to peroxisomes