Human Pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences

Molecular and Cellular Biology

Volumn 21, Issue 13, 2001, Pages 4413-4424

  Fransen, M ^a   Wylin, T ^a   Brees, C ^a   Mannaerts, G P ^a   Van Veldhoven, P P ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSKELETON PROTEIN; MEMBRANE PROTEIN; PEROXIN; PROTEIN; PROTEIN PEX10P; PROTEIN PEX11PBETA; PROTEIN PEX12P; PROTEIN PEX13P; PROTEIN PEX16P; PROTEIN PEX19P; PROTEIN PEX3P; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CELL MEMBRANE; MEMBRANE STRUCTURE; NONHUMAN; PEROXISOME; PRIORITY JOURNAL; PROTEIN INTERACTION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL FRACTIONATION; CHO CELLS; CRICETINAE; FUNGAL PROTEINS; GENES, REPORTER; HUMANS; MEMBRANE PROTEINS; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; PEROXISOMES; PLASMIDS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN SORTING SIGNALS; RECOMBINANT FUSION PROTEINS; TRANSFECTION; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 0034972812     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.13.4413-4424.2001     Document Type: Article

References (36)

1. Mitochondrial and peroxisomal targeting of 2-methylacyl-CoA racemase in human
2. A stretch of positively charged amino acids at the Nterminus of Hansenula polymorpha Pex3p is involved in incorporation of the protein into the peroxisomal membrane
3. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: Polyethylenimine
4. Mutagenic PCR
5. PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import
6. The peroxisome biogenesis factors Pex4p, Pex22p, Pex1p, and Pex6p act in the terminal steps of peroxisomal matrix protein import
7. The sorting sequence of the peroxisomal integral membrane protein PMP47 is contained within a short hydrophilic loop
8. Overexpression of Pex15p, a phosphorylated peroxisomal integral membrane protein required for peroxisome assembly in S. cerevisiae, causes proliferation of the endoplasmic reticulum membrane
9. The visualization of peroxisomal proteins containing a C-terminal targeting sequence on Western blot by using the biotinylated PTS1-receptor
10. Identification of peroxisomal proteins by using M13 phage protein VI phage display: Molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase
11. Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import
12. Peroxisome biogenesis and peroxisome biogenesis disorders
13. Isolation of intracellular membranes by means of sodium carbonate treatment: Application to endoplasmic reticulum
14. The peroxin Pex3p initiates membrane assembly in peroxisome biogenesis
15. Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein Pex19p
16. Pex19p, a farnesylated protein essential for peroxisome biogenesis
17. Peroxisome biogenesis disorders: Genetics and cell biology
18. Saccharomyces cerevisiae Pex3p and Pex19p are required for proper localization and stability of peroxisomal membrane proteins
19. Topogenesis of peroxisomal membrane protein requires a short positively charged intervening-loop sequence and flanking hydrophobic segments: Study using human membrane protein PMP34
20. Protein insertion into the peroxisomal membrane
21. Cloning and characterization of the gene encoding the human peroxisomal assembly protein Pex3p
22. Biogenesis of peroxisomes
23. Protein prenylation: A mediator of protein-protein interactions
24. Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger Syndrome, and potential role in peroxisomal membrane assembly
25. Molecular anatomy of the peroxin Pex12p. Ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p
26. Cytosolic factors mediate protein insertion into the peroxisomal membrane
27. Targeting of the 22 kDa integral peroxisomal membrane protein
28. PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis
29. The peroxin Pex19p interacts with multiple, integral membrane proteins at the peroxisomal membrane
30. Pex19p interacts with Pex3p and Pexl0p and is essential for peroxisome biogenesis in Pichia pastoris
31. Identification and characterization of the human peroxin PEX3
32. Import of peroxisomal matrix and membrane proteins
33. How peroxisomes arise
34. Discrete targeting signals direct PMP47 to oleate-induced peroxisomes in Saccharomyces cerevisiae
35. Isolation and characterization of Pas2p, a peroxisomal membrane protein essential for peroxisome biogenesis in the methylotrophic yeast Pichia pastoris
36. Protein prenylation: Molecular mechanisms and functional consequences