Evidence of P-glycoprotein sequence diversity in cyathostomins

Journal of Parasitology

Volumn 90, Issue 5, 2004, Pages 998-1003

  Drogemuller, Michaela ^a   Schnieder, T ^a   Von Samson Himmelstjerna, G ^a  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; COMPLEMENTARY DNA; GLYCOPROTEIN P; IVERMECTIN; ANTHELMINTIC AGENT; BENZIMIDAZOLE; BENZIMIDAZOLE DERIVATIVE; HELMINTH DNA; HELMINTH RNA; MESSENGER RNA;

PARASITOLOGY; PROTEIN;

ADOLESCENT; ANIMAL PARASITOSIS; ANTIBIOTIC RESISTANCE; ARTICLE; CYASTHOSTOMIN; CYASTHOSTOMUM CATINATUM; CYASTHOSTOMUM CORONATUM; CYASTHOSTOMUM PATERATUM; CYLICOCYCLUS ELONGATUS; CYLICOCYCLUS INSIGNE; CYLICOCYCLUS NASSATUS; CYLICOSTEPHANUS GOLDI; CYLICOSTEPHANUS HYBRIDUS; GENE; GENE AMPLIFICATION; GENETIC VARIABILITY; HAEMONCHUS CONTORTUS; HORSE; INTERNUCLEOTIDE BINDING DOMAIN; MAMMAL; MOLECULAR CLONING; MULTIDRUG RESISTANCE; NEMATODE; NONHUMAN; NUCLEOTIDE SEQUENCE; PGP GENE; POLYMERASE CHAIN REACTION; PROTEIN DOMAIN; PROTOZOON; AMINO ACID SEQUENCE; ANIMAL; ANIMAL DISEASE; CHEMISTRY; DRUG EFFECT; DRUG RESISTANCE; GENETICS; HORSE DISEASE; ISOLATION AND PURIFICATION; PARASITOLOGY; SEQUENCE ALIGNMENT; STRONGYLOIDEA;

AMINO ACID SEQUENCE; ANIMALS; ANTHELMINTICS; BASE SEQUENCE; BENZIMIDAZOLES; DNA, COMPLEMENTARY; DNA, HELMINTH; DRUG RESISTANCE; HORSES; IVERMECTIN; P-GLYCOPROTEINS; POLYMERASE CHAIN REACTION; RNA, HELMINTH; RNA, MESSENGER; SEQUENCE ALIGNMENT; STRONGYLE INFECTIONS, EQUINE; STRONGYLOIDEA; VARIATION (GENETICS);

EID: 13844271249     PISSN: 00223395     EISSN: None     Source Type: Journal    
DOI: 10.1645/GE-3312     Document Type: Article

References (32)

1. BEUGNET, F., M. GAUTHEY, AND D. KERBOEUF. 1997. Partial in vitro reversal of benzimidazole resistance by the free-living stages of Haemonchus contortus with verapamil. Veterinary Record 141: 575-576.
2. BLACKHALL, W. J., H. Y. LIU, M. XU, R. K. PRJCHARD, AND R. N. BEECH. 1998. Selection at a P-glycoprotein gene in ivermectin- and moxidectin-selected strains of Haemonchus contortus. Molecular and Biochemical Parasitology 95: 193-201.
3. _, J. F. POULIOT, R. K. PRICHARD, AND R. N. BEECH. 1998. Haemonchus contortus: Selection at a glutamate-gated chloride channel gene in ivermectin- and moxidectin-selected strains. Experimental Parasitology 90: 42-48.
4. BLAXTER, M. L., P. DE LEY, J. R. GAREY, L. X. LIU, P. SCHELDEMAN, A. VIERSTRAETE, J. R. VANFLETEREN, L. Y. MACKEY, M. DORRIS, L. M. FRISSE, J. T. VIDA, AND W. K. THOMAS. 1998. A molecular framework for the phylum Nematoda. Nature 392: 71-75.
5. BROEKS, A., B. GERRARD, R. ALLIKMETS, M. DEAN, AND R. H. PLASTERK. 1996. Homologues of human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in soil nematode Caenorhabditis elegans. EMBO Journal 15: 6132-6143.
6. _, H. W. JANSSEN, J. CALAFAT, AND R. H. PLASTERK. 1995. A P-glycoprotein protects Caenorhabditis elegans against natural toxins. EMBO Journal 14: 1858-1866.
7. CAMPBELL, W. C., W. H. D. LEANING, AND R. L. SEWARD. 1989. Use of ivermectin in horses. In Ivermectin and abamectin, W. C. Campbell (ed.). Springer, New York, p. 234-244.
8. CHILTON, N. B., H. HOSTE, G. C. HUNG, I. BEVERIDGE, AND R. B. GASSER. 1997. The 5.8S rDNA sequences of 18 species of bursate nematodes (order Strongylida): Comparison with rhabditid and tylenchid nematodes. International Journal for Parasitology 27: 119-124.
9. GOTTESMAN, M. M., AND I. PASTAN. 1993. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annual Review of Biochemistry 62: 385-427.
10. HENDERSON, D. M., C. D. SIFRI, M. RODGERS, D. F. WIRTH, N. HENDRICKSON, AND B. ULLMAN. 1992. Multidrug resistance in Leishmania donovani is conferred by amplification of a gene homologous to the mammalian mdr1 gene. Molecular and Cellular Biology 12: 2855-2865.
11. HUANG, Y. J., AND R. K. PRICHARD. 1999. Identification and stage-specific expression of two putative P-glycoprotein coding genes in Onchocerca volvulus. Molecular and Biochemical Parasitology 102: 273-281.
12. JULIANO, R. L., AND V. LINO. 1976. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochimica et Biophysica Acta 455: 152-162.
13. KAPLAN, R. M. 2002. Anthelmintic resistance in nematodes of horse. Veterinary Research 33: 491-507.
14. KERBOEUF, D., P. CHAMBRIER, Y. LE VERN, AND J. AYCARDI. 1999. Flow cytometry analysis of drug transport in Haemonchus contortus susceptible or resistant to anthelmintics. Parasitology Research 85: 118-123.
15. KLEI, T. R. 1996. Workshop summary: Equine parasitology. Veterinary Parasitology 64: 163-166.
16. KWA, M. S., M. N. OKOLI, H. SCHULZ-KEY, P. O. OKONGKWO, AND M. H. ROOS. 1998. Use of P-glycoprotein gene probes to investigate anthelmintic resistance in Haemonchus contortus and comparison with Onchocerca volvulus. International Journal for Parasitology 28: 1235-1240.
17. LEGARE, D., B. PAPADOPOULOU, G. ROY, R. MUKHOPADHYAY, A. HAIMEUR, S. DEY, K. GRONDIN, C. BROCHU, B. P. ROSEN, AND M. OUELLETTE. 1997. Efflux systems and increased trypanothione levels in arsenite-resistant Leishmania. Experimental Parasitology 87: 275-282.
18. LE JAMBRE, L. F., I. J. LENANE, AND A. J. WARDROP. 1999. A hybridisation technique to identify anthelmintic resistance genes in Haemonchus. International Journal for Parasitology 29: 1979-1985.
19. LICHTENFELS, J. R. 1975. Helminths in domestic equids. Proceedings of the Helminthological Society of Washington 42: 1-92.
20. _, V. A. KHARCHENKO, C. SOMMER, AND M. ITO. 1997. Key characters for the microscopical identification of Cylicocyclus nassatus and Cylicocyclus ashworthi (Nematoda: Cyathostominae) of the horse, Equus caballus. Journal of the Helminthological Society of Washington 64: 120-127.
21. LINCKE, C. R., I. THE, M. VAN GROENINGEN, AND P. BORST. 1992. The P-glycoprotein gene family of Caenorhabditis elegans. Cloning and characterization of genomic and complementary DNA sequences. Journal of Molecular Biology 228: 701-711.
22. MOLENTO, M. B., AND R. K. PRICHARD. 1999. Effects of the multidrug-resistance-reversing agents verapamil and CL 347,099 on the efficacy of ivermectin or moxidectin against unselected and drug-selected strains of Haemonchus contortus in jirds (Meriones unguiculatus). Parasitology Research 85: 1007-1011.
23. NARE, B., Z. LIU, R. K. PRICHARD, AND E. GEORGES. 1994. Benzimidazoles, potent anti-mitotic drugs: Substrates for the P-glycoprotein transporter in multidrug-resistant cells. Biochemical Pharmacology 48: 2215-2222.
24. PAPE, M., J. POSEDI, K. FAILING, T. SCHNIEDER, AND G. VON SAMSON-HIMMELSTJERNA. 2003. Analysis of the beta-tubulin codon 200 genotype distribution in a benzimidazole-susceptible and -resistant cyathostomin population. Parasitology 127: 53-59.
25. _, T. SCHNIEDER, AND G. VON SAMSON-HIMMELSTJERNA. 2002. Investigation of diversity and isotypes of the beta-tubulin cDNA in several small strongyle (Cyathostominae) species. Journal of Parasitology 88: 673-677.
26. ROTHWELL, J., AND N. SANGSTER. 1997. Haemonchus contortus: The uptake and metabolism of closantel. International Journal for Parasitology 27: 313-319.
27. RUBIO, J. P., AND A. F. COWMAN. 1996. The ATP-binding cassette (ABC) gene family of Plasmodium falciparum. Parasitology Today 12: 135-140.
28. SANGSTER, N. C. 1999. Pharmacology of anthelmintic resistance in cyathostomins: Will it occur with the avermectine/milbemycins? Veterinary Parasitology 85: 189-204.
29. _, S. C. BANNAN, A. S. WEISS, S. C. NULF, R. D. KLEIN, AND T. G. GEARY. 1999. Haemonchus contortus: Sequence heterogeneity of internucleotide binding domains from P-glycoprotein and an association with avermectine/milbemycin resistance. Experimental Parasitology 91: 250-257.
30. THOMPSON, J. D., D. G. HIGGINS, AND T. J. GIBSON. 1994. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Research 22: 4673-4680.
31. WILSON, C. W., S. K. VOLKMAN, S. THAITHONG, R. K. MARTIN, D. E. KYLE, W. K. MILHOUS, AND D. F. WIRTH. 1993. Amplification of pfmdr1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand. Molecular and Biochemical Parasitology 57: 151-160.
32. XU, M., M. MOLENTO, W. BLACKHALL, P. RIBEIRO, R. BEECH, AND R. PRICHARD. 1998. Ivermectin resistance in nematodes may be caused by alteration of P-glycoprotein homolog. Molecular and Biochemical Parasitology 91: 327-335.