Effects of the multidrug-resistance-reversing agents verapamil and CL 347,099 on the efficacy of ivermectin or moxidectin against unselected and drug-selected strains of Haemonchus contortus in jirds (Meriones unguiculatus)

Parasitology Research

Volumn 85, Issue 12, 1999, Pages 1007-1011

  Molento, Marcelo B ^a   Prichard, Roger K ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CL 347099; GLYCOPROTEIN P; IVERMECTIN; MOXIDECTIN; MULTIDRUG RESISTANCE REVERSING AGENT; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; HAEMONCHUS CONTORTUS; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; STRAIN DIFFERENCE; SUBCUTANEOUS DRUG ADMINISTRATION; WORM;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTINEMATODAL AGENTS; CALCIUM CHANNEL BLOCKERS; DRUG INTERACTIONS; DRUG RESISTANCE, MULTIPLE; DRUG THERAPY, COMBINATION; FEMALE; GERBILLINAE; HAEMONCHIASIS; HAEMONCHUS; IVERMECTIN; MACROLIDES; VERAPAMIL;

ANIMALIA; HAEMONCHUS CONTORTUS; MERIONES UNGUICULATUS;

EID: 0032753556     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004360050673     Document Type: Article

References (18)

1. Beugnet F, Gauthey M, Kerboeuf D (1997) Partial in vitro reversal of benzimidazole resistance by the free-living stages of Haemonchus contortus. Vet Parasitol 141: 575-576
2. Blackball W, Liu H-Y, Xu M, Prichard R, Beech R (1998) Selection at a P-glycoprotein gene in ivermectin and moxidectin-selected strains of Haemonchus contortus. Mol Biochem Parasitol 95: 193-201
3. Campbell WC (1989) Ivermectin and abamectin. Springer, Berlin Heidelberg New York, p 363
4. Chen C-J, Chin JE, Ueda K, Clark DP, Gottesman MM, Roninson IB (1986) Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell 47: 381-389
5. Coles GC, Stafford KA, MacKay PH (1998) Ivermectin-resistance Cooperia species from calves on a farm in Somerset. Vet Rec 142: 255-256
6. Conder GA, Johnson SS, Hall AD, Fleming MW, Mills MD, Guimond PM (1992) Growth and development of Haemonchus contortus in jirds, Meriones unguiculatus. J Parasitol 78: 492-497
7. Darge K, Büttner DW (1995) Ivermectin treatment of hyperrre-active onchodermatitis (sowda) in Liberia. Trop Med Parasitol 46: 206-212
8. Gottesman MN, Pastan I (1993) Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 62: 385-427
9. Greenberger LM, Collins KI, Annable T, Boni JP, May MK, Lai FM, Kramer R, Citeralla RV, Hallett WA, Powell D (1996) α-(3,4-Dimethyoxyphenyl)-3, 4-dihydro-6, 7-dimethoxy-α-[(4-methylphenyl)thio]-2(1H)-iso-quinolineheptanenitrile (CL 329, 753): a novel chemosensitizing agent for P-glycoprotein-mediated resistance with improved biological properties compared with verapamil and cyclosporin A. Oncol Res 8: 207-218
10. Katzung BG (1995) Basic and clinical pharmacology, 6th edn. Appleton and Lange, Norwalk, Connecticut
11. Kerboeuf D, Chambrier P, Les Vern Y, Aycardi J (1999) Flow cytometry analysis of drug transport mechanisms in Haemonchus contortus susceptible or resistant to anthelmintics. Parasitol Res 85: 118-123
12. Leathwick DM (1995) A case of moxidectin failing to control ivermectin resistant Ostertagia species in goats. Vet Rec 136: 443-444
13. 2+ channel density in rat cardiac tissue. Pharmacology 49: 23-33
14. McTavish D, Sorkin EM (1989) Verapamil: an update review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension. Drugs 38: 19-76
15. Ranjan S, Trudeau C, Prichard RK, Klutzleben R von, Carrier D (1992) Efficacy of moxidectin against naturally acquired nematode infections in cattle. Vet Parasitol 41: 227-231
16. Sangster NC, Bannan SC, Weiss AS, Nulf SC, Klein RD, Geary TG (1999) Haemonchus contortus: sequence heterogeneity of internucleotide binding domains from P-glycoproteins and an association with avermectin/milbemycin resistance. Exp Parasitol 91: 250-257
17. Watanabe T, Tsuge H, Oh-Hara T, Naito M, Tsuruo T (1995) Comparative study on reversal efficacy of SDZ PSC 833, cyclosporin A and verapamil on multidrug resistance in vitro and in vivo. Acta Oncol 34: 235-241
18. Xu M, Molento M, Blackhall W, Ribeiro P, Beech R, Prichard R (1998) Ivermectin resistance in nematodes may be caused by alteration of P-glycoprotein homolog. Mol Biochem Parasitol 91: 327-335