Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice

Gastroenterology

Volumn 122, Issue 2, 2002, Pages 406-414

  Marten, Katharina ^a   Bremer, Christoph ^a   Khazaie, Khashayarsha ^b   Sameni, Mansoureh ^c   Sloane, Bonnie ^c   Tung, ChingHsuan ^a   Weissleder, Ralph ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN B;

ADENOMA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER SCREENING; CONTROLLED STUDY; DYSPLASIA; ENZYME ACTIVITY; INTESTINE TUMOR; MOUSE; NEAR INFRARED SPECTROSCOPY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL;

EID: 0036161155     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2002.30990     Document Type: Article

References (47)

1. Colorectal cancer screening: Clinical guidelines and rationale
2. The National Polyp study. Patient and polyp characteristics associated with high-grade dysplasia in colorectal adenomas
3. Long-term risk of colorectal cancer after excision of rectosigmoid adenomas
4. Molecular dissection of multi-stage tumorigenesis in transgenic mice
5. Endoscopic diagnostics
6. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
7. Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer
8. The many faces of the tumor suppressor gene APC
9. Cancer genetics: Tumor suppressor meets oncogene
10. Lessons from hereditary colorectal cancer
11. Recent advances in research on multistage tumorigenesis
12. Molecular biology of colorectal cancer
13. Unraveling the role of proteases in cancer
14. New concepts of molecular biology for colon carcinogenesis
15. Beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer
16. The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors
17. Increased gelatinase A (MMP-2) and cathepsin B activity in invasive tumor regions of human colon cancer samples
18. Comparative localization of cathepsin B protein and activity in colorectal cancer
19. The role of cysteine and serine proteases in colorectal carcinoma
20. In vivo imaging of tumors with protease-activated near-infrared fluorescent probes
21. In vivo imaging of proteolytic enzyme activity using a novel molecular reporter
22. In vivo molecular target assessment of matrix metalloproteinase inhibition
23. Near infrared optical imaging system to detect tumor protease activity
24. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse
25. Min /+ mice with concomitant loss of Apc+ from all tumor lineages
26. Studies of neoplasia in the min mouse
27. Human tumour cathepsin B
28. Indocyanine-green angiography
29. Preclinical evaluation and phase I clinical trial of a 99mTc-labeled synthetic polymer used in blood pool imaging
30. Cathepsin B expression in colorectal carcinomas correlates with tumor progression and shortened patient survival
31. Cathepsin B and tumor-associated laminin expression in the progression of colorectal adenoma to carcinoma
32. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
33. Inactivation of both APC alleles in human and mouse tumors
34. Loss of Apc+ in intestinal adenomas from Min mice
35. Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)
36. N-ethyl-N-nitrosourea treatment of multiple intestinal neoplasia (Min) mice: Age-related effects on the formation of intestinal adenomas, cystic crypts, and epidermoid cysts
37. Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene
38. Growth factors in the extracellular matrix
39. Receptor targeted optical imaging of tumors with near infrared fluorescent ligands
40. The structure of the chromophore within DsRed, a red fluorescent protein from coral
41. Bioluminescent indicators in living mammals
42. Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement
43. Chromoendoscopy-where is it useful?
44. High-resolution chromoendoscopy for the diagnosis of diminutive colon polyps: Implications for colon cancer screening
45. Ultraviolet laser-induced fluorescence of colonic polyps
46. Fluorescence endoscopic imaging of human colonic adenomas
47. In vivo identification of colonic dysplasia using fluorescence endoscopic imaging