Expression of different p63 variants in healing skin wounds suggests a role of p63 in reepithelialization and muscle repair

Wound Repair and Regeneration

Volumn 13, Issue 1, 2005, Pages 41-50

  Bamberger, Casimir ^a   Hafner, Annina ^a   Schmale, Hartwig ^b   Werner, Sabine ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; PROTEIN P63; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NP63ALPHA; TRANSCRIPTION FACTOR NP63GAMMA; TRANSCRIPTION FACTOR TAP63ALPHA; TRANSCRIPTION FACTOR TAP63GAMMA; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; DERMIS; EPITHELIZATION; GENETIC CONSERVATION; KERATINOCYTE; MUSCLE INJURY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; SKIN INJURY; WOUND HEALING;

ANIMALS; CELL PROLIFERATION; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION; GENES, TUMOR SUPPRESSOR; KERATINOCYTES; MICE; MICE, INBRED BALB C; MODELS, ANIMAL; PHOSPHOPROTEINS; SKIN; TRANS-ACTIVATORS; TUMOR SUPPRESSOR PROTEINS; WOUND HEALING;

EID: 13844250300     PISSN: 10671927     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1067-1927.2005.130106.x     Document Type: Article

References (37)

1. Yang A, Kaghad M, Caput D, McKeon F. On the shoulders of giants: p63, p73 and the rise of p53. Trends Genet 2002;18:90-5.
2. Urist M, Prives C. P53 leans on its siblings. Cancer Cell 2002;1:311-3.
3. Moll UM, Erster S, Zaika A. P53, p63 and p73 - solos, alliances and feuds among family members. Biochim Biophys Acta 2001;1552:47-59.
4. Yang A, McKeon F. P63 and p73: p53 mimics, menaces and more. Nat Rev Mol Cell Biol 2000;1:199-207.
5. Mills AA, Zheng B, Wang XJ, Vogel H, Roop DR, Bradley A. P63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 1999;398:708-13.
6. Yang A, Schweitzer R, Sun D, Kaghad M, Walker N, Bronson RT, Tabin C, Sharpe A, Caput D, Crum C, McKeon F. P63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 1999;398:714-8.
7. Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dotsch V, Andrews NC, Caput D, McKeon F. P63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell 1998;2:305-16.
8. Westfall MD, Mays DJ, Sniezek JC, Pietenpol JA. The DeltaNp63-alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations. Mol Cell Biol 2003;23: 2264-76.
9. Ghioni P, Bolognese F, Duijf PH, Van Bokhoven H, Mantovani R, Guerrini L. Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domains. Mol Cell Biol 2002;22:8659-68.
10. Serber Z, Lai HC, Yang A, Ou HD, Sigal MS, Kelly AE, Darimont BD, Duijf PH, Van Bokhoven H, McKeon F, Dotsch V. A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism. Mol Cell Biol 2002;22:8601-11.
11. Dietz S, Rother K, Bamberger C, Schmale H, Mossner J, Engeland K. Differential regulation of transcription and induction of programmed cell death by human p53-family members p63 and p73. FEBS Lett 2002;525:93-9.
12. Yamaguchi K, Wu L, Caballero OL, Hibi K, Trink B, Resto V, Cairns P, Okami K, Koch WM, Sidransky D, Jen J. Frequent gain of the p40/p51/p63 gene locus in primary head and neck squamous cell carcinoma. Int J Cancer 2000;86:684-9.
13. Patturajan M, Nomoto S, Sommer M, Fomenkov A, Hibi K, Zangen R, Poliak N, Califano J, Trink B, Ratovitski E, Sidransky D. DeltaNp63 induces beta-catenin nuclear accumulation and signaling. Cancer Cell 2002;1:369-79.
14. Stenn KS, Paus R. Controls of hair follicle cycling. Physiol Rev 2001;81:449-94.
15. Alonso L, Fuchs E. Stem cells in the skin: waste not, want not. Genes Dev 2003;17:1189-200.
16. Parsa R, Yang A, McKeon F, Green H. Association of p63 with proliferative potential in normal and neoplastic human keratinocytes. J Invest Dermatol 1999;113:1099-105.
17. Pellegrini G, Dellambra E, Golisano O, Martinelli E, Fantozzi I, Bondanza S, Ponzin D, McKeon F, De Luca M. P63 identifies keratinocyte stem cells. Proc Natl Acad Sci USA 2001;98:3156-61.
18. Koster MI, Kim S, Mills AA, DeMayo FJ, Roop DR. P63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev 2004;18:126-31.
19. Bamberger C, Schmale H. Identification and tissue distribution of novel KET/p63 splice variants. FEBS Lett 2001;501:121-6.
20. Bamberger C, Pollet D, Schmale H. Retinoic acid inhibits downregulation of DeltaNp63alpha expression during terminal differentiation of human primary keratinocytes. J Invest Dermatol 2002;118:133-8.
21. Noszczyk BH, Majewski ST. P63 expression during normal cutaneous wound healing in humans. Plast Reconstr Surg 2001;108: 1242-7.
22. Martin P. Wound healing - aiming for perfect skin regeneration. Science 1997;276:75-81.
23. Clark JA, Leung KS, Cheng JC, Leung PC. The hypertrophic scar and microcirculation properties. Burns 1996;22:447-50.
24. Grose R, Werner S. Wound healing studies in transgenic and knockout mice. Meth Mol Med 2003;78:191-216.
25. Munz B, Wiedmann M, Lochmuller H, Werner S. Cloning of novel injury-regulated genes. Implications for an important role of the muscle-specific protein skNAC in muscle repair. J Biol Chem 1999;274:13305-10.
26. Werner S, Smola H, Liao X, Longaker MT, Krieg T, Hofschneider PH, Williams LT. The function of KGF in morphogenesis of epithelium and reepithelialization of wounds. Science 1994;266:819-22.
27. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-9.
28. 2+-binding proteins S100A8 and S100A9 are encoded by novel injury-regulated genes. J Biol Chem 2001;276:35818-25.
29. Wilkinson DG, Bailes JA, Champion JE, McMahon AP. A molecular analysis of mouse development from 8 to 10 days post coitum detects changes only in embryonic globin expression. Development 1987;99:493-500.
30. Werner S, Weinberg W, Liao X, Peters KG, Blessing M, Yuspa SH, Weiner RL, Williams LT. Targeted expression of a dominant-negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation. Embo J 1993;12:2635-43.
31. Shoshani T, Faerman A, Mett I, Zelin E, Tenne T, Gorodin S, Moshel Y, Elbaz S, Budanov A, Chajut A, Kalinski H, Kamer I, Rozen A, Mor O, Keshet E, Leshkowitz D, Einat P, Skaliter R, Feinstein E. Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. Mol Cell Biol 2002;22:2283-93.
32. Ellisen LW, Ramsayer KD, Johannessen CM, Yang A, Beppu H, Minda K, Oliner JD, McKeon F, Haber DA. REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. Mol Cell 2002;10:99-5-1005.
33. Nylander K, Coates PJ, Hall PA. Characterization of the expression pattern of p63alpha and DeltaNp63alpha in benign and malignant oral epithelial lesions. Int J Cancer 2000;87:368-72.
34. Ikawa S, Nakagawara A, Ikawa Y. P53 family genes: structural comparison, expression and mutation. Cell Death Differ 1999;6: 1154-61.
35. Wu G, Nomoto S, Hoque MO, Dracheva T, Osada M, Lee CC, Dong SM, Guo Z, Benoit N, Cohen Y, Rechthand P, Califano J, Moon CS, Ratovitski E, Jen J, Sidransky D, Trink B. DeltaNp63-alpha and TAp63alpha regulate transcription of genes with distinct biological functions in cancer and development. Cancer Res 2003;63:2351-7.
36. Werner S, Peters KG, Longaker MT, Fuller-Pace F, Banda MJ, Williams LT. Large induction of keratinocyte growth factor expression in the dermis during wound healing. Proc Natl Acad Sci USA 1992;89:6896-900.
37. Fomenkov A, Huang YP, Topaloglu O, Brechman A, Osada M, Fomenkova T, Yuriditsky E, Trink B, Sidransky D, Ratovitski E. P63alpha mutations lead to aberrant splicing of keratinocyte growth factor receptor in the Hay-Wells Syndrome. J Biol Chem 2003;278:23906-14.