Transcriptionally active drugs improve adenovirus vector performance in vitro and in vivo

Gene Therapy

Volumn 7, Issue 19, 2000, Pages 1624-1630

  Gaetano, C ^a   Catalano, A ^a,b   Palumbo, R ^a   Illi, B ^a   Orlando, G ^c   Ventoruzzo, G ^a   Serino, F ^a   Capogrossi, M C ^a  

^a LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c CATHOLIC UNIVERSITY   (Italy)

Author keywords

Adenovirus; Cytomegalovirus; Gene Therapy; Retinoic acid; Transcription; Trichostatin A

Indexed keywords

BENZYLSULFONYL FLUORIDE; BETA GALACTOSIDASE; DITHIOTHREITOL; ENZYME INHIBITOR; HISTONE DEACETYLASE; LEUPEPTIN; POTASSIUM DIHYDROGEN PHOSPHATE; RETINOIC ACID; TRICHOSTATIN A; VASCULOTROPIN; VIRUS DNA; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA; ARTICLE; CATTLE; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; GENE TARGETING; GENE THERAPY; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; QUADRICEPS FEMORIS MUSCLE; RAT; RECEPTOR UPREGULATION; TARGET CELL; TRANSCRIPTION REGULATION; TRANSGENE; VASCULAR ENDOTHELIUM; VIRUS EXPRESSION; VIRUS INFECTION; VIRUS RECOMBINANT; VIRUS RECOMBINATION; VIRUS TRANSCRIPTION;

ADENOVIRIDAE; ANIMALIA; BOS TAURUS; CYTOMEGALOVIRUS; DNA VIRUSES; RNA VIRUSES;

EID: 0033760062     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301296     Document Type: Article

References (27)

1. Distribution of mouse adenovirus type 1 in intraperitoneally and intranasally infected adult outbred mice
2. Cellular immunity delimits adenoviral gene therapy strategies for the treatment of neoplastic diseases
3. Promoter attenuation in gene therapy: Interferon-γ and tumor necrosis factor-a inhibit transgene expression
4. A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus
5. Efficiency of different viral promoters in directing gene expression in mammalian cells: Effect of 3'-untranslated sequences
6. Evaluation of promoter strength for hepatic gene expression in vivo following adenovirus-mediated gene transfer
7. An AP-1 binding site is the predominant cis-acting regulatory element in the 1.2-kilobase early RNA promoter of human cytomegalovirus
8. DNA-binding proteins that interact with the 19-base pair (CRE-like) element from the HCMV major immediate early promoter in differentiating human embryonal carcinoma cells
9. Interferon-alpha inhibits the murine cytomegalovirus immediate-early gene expression by down-regulating NF-kappa B activity
10. Reactivation of the previously silenced cytomegalovirus major immediate-early promoter in the mouse liver: Involvement of NFkappa B
11. Retinoic acid receptors initiate induction of the cytomegalovirus enhancer in embryonal cells
12. Characterization of the sequences of the human cytomegalovirus enhancer that mediate differential regulation by natural and synthetic retinoids
13. Chromatin-modifying and remodeling complexes
14. Coactivator and corepressor complexes in nuclear receptor function
15. Roles of histone acetyltransferases and deacetylases in gene regulation
16. Structure of adenovirus chromatin
17. Acetylation of histone-like proteins of adenovirus type 5
18. Amplification of recombinant adenoviral transgene products occurs by inhibition of histone deacetylase
19. DNA methylation and chromatin modification
20. Large-scale chromatin structure and function
21. Chromatin structure and the regulation of gene expression: Remodeling at the MMTV promoter
22. Cellular contaminants of adeno-associated virus vector stocks can enhance transduction
23. Retinoid receptors in health and disease: Co-regulators and the chromatin connection
24. Persistence of recombinant adenovirus in vivo is not dependent on vector DNA replication
25. Safety and efficacy of in vivo gene transfer into the porcine heart with replication-deficient, recombinant adenovirus vectors
26. 165 expressed by a replication-deficient recombinant adenovirus vector induces angiogenesis in vivo
27. Shear stress increases the release of interleukin-1 and interleukin-6 by aortic endothelial cells