DNA from both high-capacity and first-generation adenoviral vectors remains intact in skeletal muscle

Human Gene Therapy

Volumn 10, Issue 3, 1999, Pages 365-373

  Chen, Hsiao Huei ^a   Mack, Lisa M ^a   Choi, So Young ^a   Ontell, Marcia ^a   Kochanek, Stefan ^b   Clemens, Paula R ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; VIRUS VECTOR;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DNA DEGRADATION; GENE EXPRESSION; GENE TRANSFER; INFLAMMATORY CELL; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; SKELETAL MUSCLE; TRANSGENE;

ADENOVIRIDAE; ANIMALS; BETA-GALACTOSIDASE; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOMEGALOVIRUS; DYSTROPHIN; EOSINE YELLOWISH-(YS); FEMALE; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; HEMATOXYLIN; MACROPHAGES; MALE; MICE; MICE, TRANSGENIC; MUSCLE, SKELETAL; MUSCLES; TERMINAL REPEAT SEQUENCES; TIME FACTORS;

ADENOVIRIDAE; ANIMALIA;

EID: 0033540620     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430349950018814     Document Type: Article

References (21)

1. CHEN, H.-H., MACK, L.M., KELLY, R., ONTELL, M., KOCHANEK, S., and CLEMENS, P.R. (1997). Persistence in muscle of an adenoviral vector that lacks all viral genes. Proc. Natl. Acad. Sci. U.S.A. 94, 1645-1650.
2. COEN, D.M. (1997). Quantitation of rare DNAs by PCR in the polymerase chain reaction. In Current Protocols in Molecular Biology. V.B. Chanda, ed. (John Wiley & Sons, Somerset, NJ) Unit 15.3.
3. COX, G.A., COLE, N.M., MATSUMURA, K., PHELPS, S.F., HAUSCHKA, S.D., CAMPBELL, K.P., FAULKNER, J.A., and CHAMBERLAIN, J.S. (1993). Overexpression of dystrophin in transgenic mdx mice eliminates dystrophic symptoms without toxicity. Nature (London) 364, 725-729.
4. DAI, Y., ROMAN, M., NAVIAUX, R.K., and VERMA, I.M. (1992). Gene therapy via primary myoblasts: Long-term expression of factor IX protein following transplantation in vivo. Proc. Natl. Acad. Sci. U.S.A. 89, 10892-10895.
5. DAI, Y., SCHWARZ, E.M., GU, D., ZHANG, W.-W., SARVETNICK, N., and VERMA, I.M. (1995). Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: Tolerization of factor IX and vector antigens allows for long-term expression. Proc. Natl. Acad. Sci. U.S.A. 92, 1401-1405.
6. FEIGENBLUM, D., and SCHNEIDER, R.J. (1996). Cap-binding protein (eukaryotic initiation factor 4E) and 4E-inactivating protein BP-1 independently regulate cap-dependent translation. Mol. Cell. Biol. 16, 5450-5457.
7. FISHER, K.J., CHOI, H., BURDA, J., CHEN, S.-J., and WILSON, J.M. (1996). Recombinant adenovirus deleted of all viral genes for gene therapy of cystic fibrosis. Virology 217, 11-22.
8. HAECKER, S.E., STEDMAN, H.H., BALICE-GORDON, R.-J., SMITH, D.B.J., GREELISH, J.P., MITCHELL, M.A., WELLS, A., SWEENEY, H.L., and WILSON, J.M. (1996). In vitro expression of full-length human dystrophin from adenoviral vectors deleted of all viral genes. Hum. Gene Ther. 7, 1907-1914.
9. HARMS, J.S., and SPLITTER, G.A. (1995). Interferon-gamma inhibits transgene expression driven by SV40 or CMV promoters but augments expression driven by the mammalian MHC I promoter. Hum. Gene Ther. 6, 1291-1297.
10. KATZ, J.P., BODIN, E.T., and COEN, D.M. (1990). Quantitative polymerase chain reaction analysis of herpes simplex virus DNA in ganglia of mice infected with replication-incompetent mutants. J. Virol. 64, 4288-4295.
11. KELLY, R., ALONSO, S., TAJBAKHSH, S., COSSU, G., and BUCKINGHAM, M. (1995). Myosin light chain 3F regulatory sequences confer regionalized cardiac and skeletal muscle expression in transgenic mice. J. Cell Biol. 129, 383-396.
12. KOCHANEK, S., CLEMENS, P.R., MITANI, K., CHEN, H.-H., CHAN, S., and CASKEY, C.T. (1996). A new adenoviral vector: Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and β-galactosidase. Proc. Natl. Acad. Sci. U.S.A. 93, 5731-5736.
13. KUMAR-SINGH, R., and CHAMBERLAIN, J.S. (1996). Encapsidated adenovirus minichromosomes allow delivery and expression of a 14 kb dystrophin cDNA to muscle cells. Hum. Mol. Genet. 5, 913-921.
14. LOCHMULLER, H., PETROF, B.J., ALLEN, C., PRESCOTT, S., MASSIE, B., and KARPATI, G. (1995). Immunosuppression by FK506 markedly prolongs expression of adenovirus-delivered transgene in skeletal muscles of adult dystrophic (mdx) mice. Biochem. Biophys. Res. Commun. 213, 569-574.
15. MACGREGOR, G.R., and CASKEY, C.T. (1989). Construction of plasmids that express E. coli β-galactosidase in mammalian cells. Nucleic Acids Res. 17, 2365.
16. MITTEREDER, N., MARCH, K.L., and TRAPNELL, B.C. (1996). Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy. J. Virol. 70, 7498-7509.
17. SCHNEIDER, R.J. (1996). Adenovirus and vaccinia virus translational control. In Translational Control. J.W.B. Hershey, M.B. Mathews, and N. Sonenberg, eds. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY) pp. 575-605.
18. VILQUIN, J.-T., GUERETTE, B., KINOSHITA, I., ROY, B., GOULET, M., GRAVEL, C., ROY, R., and TREMBLAY, J.P. (1995). FK506 immunosuppression to control the immune reactions triggered by first-generation adenovirus-mediated gene transfer. Hum. Gene Ther. 6, 1391-1401.
19. WILLS, K.N., MANEVAL, D.C., MENZEL, P., HARRIS, M.P., SUTJIPTO, S., VAILLANCOURT, M.T., HUANG, W.M., JOHNSON, D.E., ANDERSON, S.C., and WEN, S.F. (1994). Development and characterization of recombinant adenoviruses encoding human p53 for gene therapy of cancer. Hum. Gene Ther. 5, 1079-1088.
20. YANG, Y., XIANG, Z., ERTL, H.C.J., and WILSON, J.M. (1995). Up-regulation of class I major histocompatibility complex antigens by interferon γ is necessary for T-cell-mediated elimination of recombinant adenovirus-infected hepatocytes in vivo. Proc. Natl. Acad. Sci. U.S.A. 92, 7257-7261.
21. YANG, Y., HAECKER, S.E., SU, Q., and WILSON, J.M. (1996). Immunology of gene therapy with adenoviral vectors in mouse skeletal muscle. Hum. Mol. Genet. 5, 1703-1712.