Cell structure and cytokinesis alterations in multidrug-resistant Leishmania (Leishmania) amazonensis

Parasitology Research

Volumn 95, Issue 2, 2005, Pages 90-96

  Borges, V M ^a   Lopes, U G ^b   De Souza, W ^b   Vannier Santos, M A ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSKELETON PROTEIN; VINBLASTINE;

ARTICLE; CELL DIVISION; CELL FUNCTION; CELL MEMBRANE; CELL NUCLEUS; CELL STRUCTURE; CONTROLLED STUDY; CYTOARCHITECTURE; CYTOKINESIS; ELECTRON MICROSCOPY; FLAGELLUM; KINETOPLAST; LEISHMANIA; MICROTUBULE; MULTIDRUG RESISTANCE; MULTINUCLEAR CELL; MUTATION; NONHUMAN; PARASITE; PRIORITY JOURNAL; PROMASTIGOTE; WILD TYPE;

ANIMALS; CYTOKINESIS; CYTOSKELETON; DRUG RESISTANCE, MULTIPLE; LEISHMANIA MEXICANA; MICROSCOPY, ELECTRON; MICROSCOPY, ELECTRON, SCANNING; VINBLASTINE;

LEISHMANIA AMAZONENSIS;

EID: 13644251581     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00436-004-1248-8     Document Type: Article

References (61)

1. Bhattacharya G, Salem MM, Werbovetz KA (2002) Antileishmanial dinitroaniline sulfonamides with activity against parasite tubulin. Bioorg Med Chem Lett 12:2395-2398
2. Bhattacharya G, Herman J, Delfin D et al (2004) Synthesis and antitubulin activity of N(1)- and N(4)-substituted 3,5-dinitro sulfanilamides against African trypanosomes and Leishmania. J Med Chem 47:1823-1832
3. Cabral F (2001) Factors determining cellular mechanisms of resistance to antimitotic drugs. Drug Resist Updat 4:3-8
4. Cabral F, Sobel ME, Gottesman MM (1980) CHO mutants resistant to colchicine, colcemid or griseofulvin have an altered beta-tubulin. Cell 20:29-36
5. Chan MM, Fong D (1990) Inhibition of leishmanias but not host macrophages by the antitubulin herbicide trifluralin. Science 249:924-926
6. Chan MM, Grogl M, Callahan H, Fong D (1995) Efficacy of the herbicide trifluralin against four P-glycoprotein-expressing strains of Leishmania. Antimicrob Agents Chemother 39:1609-1611
7. Chow LM, Wong AK, Ullman B, Wirth DF (1993) Cloning and functional analysis of an extrachromosomally amplified multidrug resistance-like gene in Leishmania enriettii. Mol Biochem Parasitol 60:195-208
8. Coderre JA, Beverley SM, Schimke RT, Santi DV (1983) Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica. Proc Natl Acad Sci U S A 80:2132-2136
9. Court JB, Burn C, Louis DS, Moore JL (1993) The survival of cytochalasin-induced polykaryons following exposure to cytotoxic agents. Cell Biol Int 17:291-303
10. Croft SL, Yardley V (2002) Chemotherapy of leishmaniasis. Curr Pharm Des 8:319-342
11. Dantas AP, Barbosa HS, De Castro SL (2003) Biological and ultrastructural effects of the anti-microtubule agent taxol against Trypanosoma cruzi. J Submicrosc Cytol Pathol 35:287-294
12. De Souza W (1989) Components of the cell surface of trypanosomatids. Prog Protistol 3:87-184
13. De Souza W (2002) Special organelles of some pathogenic protozoa. Parasitol Res 88:1013-1025
14. Desjeux C (2000) Leishmaniasis: current situation and new perspectives. Comp Immunol Microbiol Infect Dis 27:305-318
15. Dumontet C (2000) Mechanisms of action and resistance to tubulin-binding agents. Expert Opin Investig Drugs 9:779-788
16. Erokhina MV, Shtil AA, Shushanov SS, Sidorova TA, Stavrovskaya AA (1994) Partial restoration of the actin cytoskeleton in transformed Syrian hamster fibroblasts selected for low levels of 'typical' multidrug resistance. FEBS Lett 341:295-298
17. Fine RL, Chambers TC, Sachs CW (1996) P-glycoprotein, multidrug resistance and protein kinase C. Oncologist 1:261-268
18. Fu D, Bebawy M, Kable EP, Roufogalis BD (2004) Dynamic and intracellular trafficking of P-glycoprotein-EGFP fusion protein: implications in multidrug resistance in cancer. Int J Cancer 109:174-181
19. Grellier P, Sinou V, Garreau-de Loubresse N, Bylen E, Boulard Y, Schrevel J (1999) Selective and reversible effects of vinca alkaloids on Trypanosoma cruzi epimastigote forms: blockage of cytokinesis without inhibition of the organelle duplication. Cell Motil Cytoskeleton 42:36-47
20. Grogl M, Martin RK, Oduola AM, Milhous WK, Kyle DE (1991) Characteristics of multidrug resistance in Plasmodium and Leishmania: detection of P-glycoprotein-like components. Am J Trop Med Hyg 45:98-111
21. Gueiros-Filho FJ, Viola JP, Gomes FC et al (1995) Leishmania amazonensis: multidrug resistance in vinblastine-resistant promastigotes is associated with rhodamine 123 efflux, DNA amplification, and RNA overexpression of a Leishmania mdr1 gene. Exp Parasitol 81:480-490
22. Gull K (2001) Protist tubulins: new arrivals, evolutionary relationships and insights to cytoskeletal function. Curr Opin Microbiol 4:427-432
23. Havens CG, Bryant N, Asher L et al (2000) Cellular effects of leishmanial tubulin inhibitors on L. donovani. Mol Biochem Parasitol 110:223-236
24. Henderson DM, Sifri CD, Rodgers M, Wirth DF, Hendrickson N, Ullman B (1992) Multidrug resistance in Leishmania donovani is conferred by amplification of a gene homologous to the mammalian mdr1 gene. Mol Cell Biol 12:2855-2865
25. Jacobs S (2002) An oral drug for leishmaniasis. N Engl J Med 347:1737-1738
26. Jaffrezou JP, Dumontet C, Derry WB et al (1995) Novel mechanism of resistance to paclitaxel (Taxol) in human K562 leukemia cells by combined selection with PSC 833. Oncol Res 7:517-527
27. Jha TK, Sundar S, Thakur CP et al (1999) Miltefosine, an oral agent, for the treatment of Indian visceral leishmaniasis. N Engl J Med 341:1795-1800
28. Kavallaris M, Kuo DY, Burkhart CA et al (1997) Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes. J Clin Invest 100:1282-1293
29. Kohl L, Robinson D, Bastin P (2003) Novel roles for the flagellum in cell morphogenesis and cytokinesis of trypanosomes. EMBO J 22:5336-5346
30. Lange K, Gartzke J (2001) Microvillar cell surface as a natural defense system against xenobiotics: a new interpretation of multidrug resistance. Am J Physiol Cell Physiol 281:C369-C385
31. Leandro C, Campino L (2003) Leishmaniasis: efflux pumps and chemoresistance. Int J Antimicrob Agents 22:352-357
32. Liu LX, Weller PF (1996) Antiparasitic drugs. N Engl J Med 334:1178-1184
33. Luciani F, Molinari A, Lozupone F et al (2002) P-glycoprotein-actin association through ERM family proteins: a role in P-glycoprotein function in human cells of lymphoid origin. Blood 99:641-648
34. Manetti F, Maccari L, Corelli F, Botta M (2004) 3-D QSAR models of interactions between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA): a survey on taxanes and epothilones. Curr Top Med Chem 4:203-217
35. Matthews KR, Sherwin T, Gull K (1995) Mitochondrial genome repositioning during the differentiation of the African trypanosome between life cycle forms is microtubule mediated. J Cell Sci 108:2231-2239
36. McKeegan KS, Borges-Walmsley MI, Walmsley AR (2003) The structure and function of drug pumps: an update. Trends Microbiol 11:21-297
37. Molyneux DH, Killick-Kendrick R (1987) Morphology, ultrastructure and life cycles. In: Peters W, Killick-Kendrick R (eds) The leishmaniases in biology and edicine. Academic Press, New York, pp 121-176
38. Moulay L, Robert-Gero M, Brown S, Gendron MC, Tournier F (1996) Sinefungin and taxol effects on cell cycle and cytoskeleton of Leishmania donovani promastigotes. Exp Cell Res 226:283-291
39. Murta SM, Dos Santos WG, Anacleto C, Nirde P, Moreira ES, Romanha AJ (2001) Drug resistance in Trypanosoma cruzi is not associated with amplification or overexpression of P-glycoprotein (PGP) genes. Mol Biochem Parasitol 117:223-228
40. Okada Y (1997) Volume expansion-sensing outward-rectifier Cl-channel: fresh start to the molecular identity and volume sensor. Am J Physiol 273:C755-C789
41. Perez-Victoria JM, Di Pietro A, Barron D, Ravelo AG, Castanys S, Gamarro F (2002) Multidrug resistance phenotype mediated by the P-glycoprotein-like transporter in Leishmania: a search for reversal agents. Curr Drug Targets 3:311-333
42. Perez-Victoria FJ, Castanys S, Gamarro F (2003a) Leishmania donovani resistance to miltefosine involves a defective inward translocation of the drug. Antimicrob Agents Chemother 47:2397-2403
43. Perez-Victoria FJ, Gamarro F, Ouellette M, Castanys S (2003b) Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance. J Biol Chem 278:49965-49971
44. Pimenta PF, De Souza W (1985) Fine structure and cytochemistry of the endoplasmic reticulum and its association with the plasma membrane of Leishmania mexicana amazonensis. J Submicrosc Cytol 17:413-419
45. Ploubidou A, Robinson DR, Docherty RC, Ogbadoyi EO, Gull K (1999) Evidence for novel cell cycle checkpoints in trypanosomes: kinetoplast segregation and cytokinesis in the absence of mitosis. J Cell Sci 112:4641-4650
46. Ponte-Sucre A (2003) Physiological consequences of drug resistance in Leishmania and their relevance for chemotherapy. Kinetoplastid Biol Dis 2:14
47. Sahasrabuddhe AA, Bajpai VK, Gupta CM (2004) A novel form of actin in Leishmania: molecular characterization, subcellular localization and association with subpellicular microtubules. Mol Biochem Parasitol 134:105-114
48. Sangster N, Batterham P, Chapman HD et al (2002) Resistance to antiparasitic drugs: the role of molecular diagnosis. Int J Parasitol 32:637-653
49. Saraiva EM, Vannier-Santos MA, Silva-Filho FC, De Souza W (1989) Anionic site behavior in Leishmania and its role in the parasite-macrophage interaction. J Cell Sci 93:481-489
50. Sardini A, Mintenig GM, Valverde MA et al (1994) Drug efflux mediated by the human multidrug resistance P-glycoprotein is inhibited by cell swelling. J Cell Sci 107:3281-3290
51. Singh N, Singh RT, Sundar S (2003) Novel mechanism of drug resistance in kala azar field isolates. J Infect Dis 188:600-607
52. Takeshita H, Kusuzaki K, Ashihara T, Gebhardt MC, Mankin HJ, Hirasawa Y (1998) Actin organization associated with the expression of multidrug resistant phenotype in osteosarcoma cells and the effect of actin depolymerization on drug resistance. Cancer Lett 126:75-81
53. Tannert A, Pohl A, Pomorski T, Herrmann A (2003) Protein-mediated transbilayer movement of lipids in eukaryotes and prokaryotes: the relevance of ABC transporters. Int J Antimicrob Agents 22:177-187
54. Tsuruo T, Iida H (1986) Effects of cytochalasins and colchicine on the accumulation and retention of daunomycin and vincristine in drug resistant tumor cells. Biochem Pharmacol 35:1087-1090
55. Vannier-Santos MA, Pimenta PF, De Souza W (1988) Effects of phorbol ester on Leishmania mexicana amazonensis: an ultrastructural and cytochemical study. J Submicrosc Cytol Pathol 20:583-593
56. Vannier-Santos MA, Saraiva EM, Martiny A, Neves A, De Souza W (1992) Fibronectin shedding by Leishmania may influence the parasite-macrophage interaction. Eur J Cell Biol 59:389-397
57. Vannier-Santos MA, Urbina JA, Martiny A, Neves A, De Souza W (1995) Alterations induced by the antifungal compounds ketoconazole and terbinafine in Leishmania. J Eukaryot Microbiol 42:337-346
58. Vannier-Santos MA, Martiny A, Se Souza W (2002) Cell biology of Leishmania spp.: invading and evading. Curr Pharm Des 8:297-318
59. Vedrenne C, Giroud C, Robinson DR et al. (2002) Two related subpellicular cytoskeleton-associated proteins in Trypanosoma brucei stabilize microtubules. Mol Biol Cell 13:1058-1070
60. Werbovetz KA (2002) Tubulin as an antiprotozoal drug target. Mini Rev Med Chem 2:519-529
61. Wong AK, Chow LM, Wirth DF (1994) A homologous recombination strategy to analyze the vinblastine resistance property of the V-circle in Leishmania. Mol Biochem Parasitol 64:75-86