Cellular effects of leishmanial tubulin inhibitors on L. donovani

Molecular and Biochemical Parasitology

Volumn 110, Issue 2, 2000, Pages 223-236

  Havens, Courtney G ^a   Bryant, Nelva ^a   Asher, Ludmila ^a   Lamoreaux, Laurie ^b   Perfetto, Steve ^b   Brendle, James J ^a   Werbovetz, Karl A ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE   (United States)

Author keywords

Ansamitocin P3; Hemiasterlin; Leishmania; Taxol; Tubulin

Indexed keywords

ANSAMITOCIN P 3; ANTILEISHMANIAL AGENT; HEMIASTERLIN; PACLITAXEL; PENTAMIDINE; THIOCYANIC ACID DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG; WR 85915;

ANTIPROTOZOAL ACTIVITY; ARTICLE; DRUG MECHANISM; DRUG TARGETING; LEISHMANIA; LEISHMANIA DONOVANI; MICROTUBULE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIPROTOZOAL AGENTS; CELL CYCLE; DNA, PROTOZOAN; FLOW CYTOMETRY; LEISHMANIA DONOVANI; MAYTANSINE; MICROSCOPY, ELECTRON; MICROSCOPY, FLUORESCENCE; OLIGOPEPTIDES; OXADIAZOLES; PACLITAXEL; TUBULIN;

EID: 0033737632     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(00)00272-3     Document Type: Article

References (34)

1. The epidemic of visceral leishmaniasis in western Upper Nile, southern Sudan: Course and impact from 1984 to 1994
2. Practical progress and new drugs for changing patterns of leishmaniasis
3. Purification, characterization, and drug susceptibility of tubulin from Leishmania
4. Microtubular cytoskeletons of parasitic protozoa
5. Purification and assembly in vitro of tubulin from Trypanosoma brucei brucei
6. Effects of new antimitotic antibiotics, ansamitocins, on the growth of murine tumors in vivo and on the assembly of microtubules in vitro
7. Cytotoxic and tubulin-interactive hemiasterlins from Auletta sp. and Siphonochalina spp. sponges
8. Substoichiometric binding of taxol suppresses microtubule dynamics
9. Basal body movements as a mechanism for mitochondrial genome segregation in the trypanosome cell cycle
10. Taxol, a microtubule stabilizing agent, blocks the replication of Trypanosoma cruzi
11. Sinefungin and taxol effects on cell cycle and cytoskeleton of Leishmania donovani promastigotes
12. 2,4-Dichlorobenzyl thiocyanate, an antimitotic agent that alters microtubule morphology
13. Mechanism of action of the antimitotic drug 2,4-dichlorobenzyl thiocyanate: Alkylation of sulfhydryl group(s) of β-tubulin
14. Selective cleavage of kinetoplast DNA minicircles promoted by antitrypanosomal drugs
15. Pentamidine uptake in Leishmania donovani and Leishmania amazonensis promastigotes and axenic amastigotes
16. Effects of cationic diamidines on polyamine content and uptake on Leishmania infantum in in vitro cultures
17. Microtubule polarity and dynamics in the control of organelle positioning, segregation, and cytokinesis in the trypanosome cell cycle
18. The cell division cycle of Trypanosoma brucei brucei: Timing of event markers and cytoskeletal modulations
19. Ultrastructural study of promastigotes of Leishmania from reptiles
20. Interactions of the sponge-derived antimitotic tripeptide hemiasterlin with tubulin: Comparison with dolastatin 10 and cryptophycin 1
21. Two ultrastructurally distinct tubulin paracrystals induced in sea-urchin eggs by vinblastine sulphate
22. Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Evidence for the role of microtubule dynamics in mitosis
23. Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol
24. Mitotic block induced in HeLa cells by low concentrations of paclitaxel (taxol) results in abnormal mitotic exit and apoptotic cell death
25. p53-independent apoptosis and p53-dependent block of DNA rereplication following mitotic spindle inhibition in human cells
26. The mode of action of taxol: Apoptosis at low concentration and necrosis at high concentration
27. Leishmania mexicana: Enzyme activities of amastigotes and promastigotes and their inhibition by antimonials and arsenicals
28. Trypanothione is the primary target for arsenical drugs against African trypanosomes
29. Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals
30. Cysteine protease inhibitors as chemotherapy for parasitic infections
31. Structure of the alpha,beta tubulin dimer by electron crystallography
32. Beta tubulin gene of the parasitic protozoan Leishmania mexicana