Testisin, a glycosyl-phosphatidylinositol-linked serine protease, promotes malignant transformation in vitro and in vivo

Cancer Research

Volumn 65, Issue 3, 2005, Pages 868-878

  Tang, Tenny ^a   Kmet, Muriel ^a   Corral, Laura ^a   Vartanian, Steffan ^a   Tobler, Andreas ^a   Papkoff, Jackie ^a  

^a diaDexus Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGAR; CELL SURFACE PROTEIN; GLYCOSYLPHOSPHATIDYLINOSITOL; MESSENGER RNA; SERINE PROTEINASE; SMALL INTERFERING RNA; TESTISIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CARCINOGENESIS; CATALYSIS; CELL CULTURE; CELL GROWTH; CELL LINE; COLONY FORMATION; CONTROLLED STUDY; CULTURE MEDIUM; EPITHELIUM CELL; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; MALIGNANT TRANSFORMATION; MOUSE; MOUSE STRAIN; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; TUMOR CELL LINE; TUMOR GROWTH; VALIDATION PROCESS;

ANIMALS; APOPTOSIS; CELL TRANSFORMATION, NEOPLASTIC; DISEASE PROGRESSION; FEMALE; GLYCOSYLPHOSPHATIDYLINOSITOLS; HELA CELLS; HUMANS; MEMBRANE PROTEINS; MICE; MICE, SCID; NEOPLASM TRANSPLANTATION; OVARIAN NEOPLASMS; RNA, SMALL INTERFERING; SERINE ENDOPEPTIDASES; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS; TUMOR STEM CELLS;

EID: 13444263249     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. American Cancer Society. Cancer facts and figures. Atlanta (GA): American Cancer Society; 2004.
2. Jemal A, Tiwari RC, Murray T, et al. Cancer statistics, 2004. CA Cancer J Clin 2004;54:8-29.
3. Allen DG, Coulter J. Survival of patients with epithelial ovarian cancer and the effect of lymphadenectomy in those with stage 3 disease. Aust N Z J Obstet Gynaecol 1999;39:420-4.
4. Engel J, Eckel R, Schubert-Fritschle G, et al. Moderate progress for ovarian cancer in the last 20 years: prolongation of survival, but no improvement in the cure rate. Eur J Cancer 2002;38:2435-45.
5. Heintz AP, Odicino F, Maisonneuve P, et al. Carcinoma of the ovary. Int J Gynaecol Obstet 2003;83 Suppl 1:135-66.
6. Ozols RF. Update on the management of ovarian cancer. Cancer J 2002;8 Suppl 1:S22-30.
7. Barrett AJ, Rawlings ND. Families and clans of serine peptidases. Arch Biochem Biophys 1995;318:247-50.
8. Perona JJ, Craik CS. Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold. J Biol Chem 1997;272:29987-90.
9. Hooper JD, Clements JA, Quigley JP, Antalis TM. Type II transmembrane serine proteases. Insights into an emerging class of cell surface proteolytic enzymes. J Biol Chem 2001;276:857-60.
10. Netzel-Arnett S, Hooper JD, Szabo R, et al. Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer. Cancer Metastasis Rev 2003;22:237-58.
11. Lang JC, Schuller DE. Differential expression of a novel serine protease homologue in squamous cell carcinoma of the head and neck. Br J Cancer 2001;84:237-43.
12. Magee JA, Araki T, Patil S, et al. Expression profiling reveals hepsin overexpression in prostate cancer. Cancer Res 2001;61:5692-6.
13. Oberst MD, Johnson MD, Dickson RB, et al. Expression of the serine protease matriptase and its inhibitor HAI-1 in epithelial ovarian cancer: correlation with clinical outcome and tumor clinicopathological parameters. Clin Cancer Res 2002;8:1101-10.
14. Tanimoto H, Yan Y, Clarke J, et al. Hepsin, a cell surface serine protease identified in hepatoma cells, is overexpressed in ovarian cancer. Cancer Res 1997;57:2884-7.
15. Vaarala MH, Porvari K, Kyllonen A, Lukkarinen O, Vihko P. The TMPRSS2 gene encoding transmembrane serine protease is overexpressed in a majority of prostate cancer patients: detection of mutated TMPRSS2 form in a case of aggressive disease. Int J Cancer 2001;94:705-10.
16. Wallrapp C, Hahnel S, Muller-Pillasch F, et al. A novel transmembrane serine protease (TMPRSS3) overexpressed in pancreatic cancer. Cancer Res 2000;60:2602-6.
17. Aimes RT, Zijlstra A, Hooper JD, et al. Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesis. Thromb Haemost 2003;89:561-72.
18. Hooper JD, Nicol DL, Dickinson JL, et al. Testisin, a new human serine proteinase expressed by premeiotic testicular germ cells and lost in testicular germ cell tumors. Cancer Res 1999;59:3199-205.
19. Hooper JD, Bowen N, Marshall H, et al. Localization, expression and genomic structure of the gene encoding the human serine protease testisin. Biochim Biophys Acta 2000;1492:63-71.
20. Inoue M, Kanbe N, Kurosawa M, Kido H. Cloning and tissue distribution of a novel serine protease esp-1 from human eosinophils. Biochem Biophys Res Commun 1998;252:307-12.
21. Shigemasa K, Underwood LJ, Beard J, et al. Overexpression of testisin, a serine protease expressed by testicular germ cells, in epithelial ovarian tumor cells. J Soc Gynecol Investig 2000;7:358-62.
22. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001;411:494-8.
23. Hannon GJ. RNA interference. Nature 2002;418:244-51.
24. Harborth J, Elbashir SM, Bechert K, Tuschl T, Weber K. Identification of essential genes in cultured mammalian cells using small interfering RNAs. J Cell Sci 2001;114:4557-65.
25. Michaelson JS, Leder P. RNAi reveals anti-apoptotic and transcriptionally repressive activities of DAXX. J Cell Sci 2003;116:345-52.
26. Yan W, Shen F, Dillon B, Ratnam M. The hydrophobic domains in the carboxyl-terminal signal for GPI modification and in the amino-terminal leader peptide have similar structural requirements. J Mol Biol 1998;275:25-33.
27. Concha NO, Abdel-Meguid SS. Controlling apoptosis by inhibition of caspases. Curr Med Chem 2002;9:713-26.
28. Kiechle FL, Zhang X. Apoptosis: biochemical aspects and clinical implications. Clin Chim Acta 2002;326:27-45.
29. Louro ID, McKie-Bell P, Gosnell H, Brindley BC, Bucy RP, Ruppert JM. The zinc finger protein GLI induces cellular sensitivity to the mTOR inhibitor rapamycin. Cell Growth Differ 1999;10:503-16.
30. Muller T, Bain G, Wang X, Papkoff J. Regulation of epithelial cell migration and tumor formation by β-catenin signaling. Exp Cell Res 2002;280:119-33.
31. Weng Z, Xin M, Pablo L, et al. Protection against anoikis and down-regulation of cadherin expression by a regulatable β-catenin protein. J Biol Chem 2002;277:18677-86.
32. Friedrich R, Fuentes-Prior P, Ong E, et al. Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase. J Biol Chem 2002;277:2160-8.
33. Deshane J, Cabrera G, Grim JE, et al. Targeted eradication of ovarian cancer mediated by intracellular expression of anti-erbB-2 single-chain antibody. Gynecol Oncol 1995;59:8-14.
34. Nielsen UB, Adams GP, Weiner LM, Marks JD. Targeting of bivalent anti-ErbB2 diabody antibody fragments to tumor cells is independent of the intrinsic antibody affinity. Cancer Res 2000;60:6434-40.
35. Nicol D, Teh BT, Strachan N, Ward G, Martin N. Familial testicular carcinoma: in search of genetic triggers. Aust N Z J Surg 1994;64:418-20.
36. Nelson JE, Krawetz SA. Characterization of a human locus in transition. J Biol Chem 1994;269:31067-73.
37. Honda A, Yamagata K, Sugiura S, Watanabe K, Baba TA. mouse serine protease TESP5 is selectively included into lipid rafts of sperm membrane presumably as a glycosylphosphatidylinositol-anchored protein. J Biol Chem 2002;277:16976-84.
38. Danielsen EM, Hansen GH. Lipid rafts in epithelial brush borders: atypical membrane microdomains with specialized functions. Biochim Biophys Acta 2003;1617:1-9.
39. Pike LJ. Lipid rafts: bringing order to chaos. J Lipid Res 2003;44:655-67.
40. Magee T, Pirinen N, Adler J, Pagakis SN, Parmryd I. Lipid rafts: cell surface platforms for T cell signaling. Biol Res 2002;35:127-31.
41. Tansey MG, Baloh RH, Milbrandt J, Johnson EM Jr. GFRα-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival. Neuron 2000;25:611-23.
42. Scarman A, Hooper JD, Boucaut KJ, et al. Organization and chromosomal localization of the murine testisin gene encoding a serine protease temporally expressed during spermatogenesis. Eur J Biochem 2001;268:1250-8.
43. Kohno N, Yamagata K, Yamada S, Kashiwabara S, Sakai Y, Baba T. Two novel testicular serine proteases, TESP1 and TESP2, are present in the mouse sperm acrosome. Biochem Biophys Res Commun 1998;245:658-65.
44. Yamagata K, Murayama K, Okabe M, et al. Acrosin accelerates the dispersal of sperm acrosomal proteins during acrosome reaction. J Biol Chem 1998;273:10470-4.
45. Vallet V, Chraibi A, Gaeggeler HP, Horisberger JD, Rossier BC. An epithelial serine protease activates the amiloride-sensitive sodium channel. Nature 1997;389:607-10.
46. Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF. Met, metastasis, motility and more. Nat Rev Mol Cell Biol 2003;4:915-25.
47. Kataoka H, Miyata S, Uchinokura S, Itoh H. Roles of hepatocyte growth factor (HGF) activator and HGF activator inhibitor in the pericellular activation of HGF/scatter factor. Cancer Metastasis Rev 2003;22:223-36.
48. Lee SL, Dickson RB, Lin CY. Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease. J Biol Chem 2000;275:36720-5.
49. Miyazawa K, Shimomura T, Naka D, Kitamura N. Proteolytic activation of hepatocyte growth factor in response to tissue injury. J Biol Chem 1994;269:8966-70.
50. Prenzel N, Zwick E, Daub H, et al. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 1999;402:884-8.